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1.13.11.46: 4-hydroxymandelate synthase

This is an abbreviated version!
For detailed information about 4-hydroxymandelate synthase, go to the full flat file.

Word Map on EC 1.13.11.46

Reaction

4-hydroxyphenylpyruvate
+
O2
=
(S)-4-hydroxymandelate
 +
CO2

Synonyms

(S)-hydroxymandelate synthase, 4-(S) hydroxymandelate synthase, 4-hydroxyphenylpyruvate dioxygenase II, HMS, HPDL, hydroxymandelate synthase, hydroxyphenylpyruvate dioxygenase-like

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
                1.13.11.46 4-hydroxymandelate synthase

Engineering

Engineering on EC 1.13.11.46 - 4-hydroxymandelate synthase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
I216N
-
site-directed mutagenesis, the mutant shows increased catalytic efficiency compared to the wild-type enzyme, the mutant produces 90% 4-hydroxmandelate and 10% 4-hydroxyphenylacetate from 4-hydroxyphenylpyruvate, which differs from the wild-type, that does not produce any 4-hydroxyphenylacetate
S201A
T214P
-
site-directed mutagenesis, mutant shows decreased catalytic efficiency compared to the wild-type enzyme