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1.13.11.46: 4-hydroxymandelate synthase

This is an abbreviated version!
For detailed information about 4-hydroxymandelate synthase, go to the full flat file.

Word Map on EC 1.13.11.46

Reaction

4-hydroxyphenylpyruvate
+
O2
=
(S)-4-hydroxymandelate
+
CO2

Synonyms

(S)-hydroxymandelate synthase, 4-(S) hydroxymandelate synthase, 4-hydroxyphenylpyruvate dioxygenase II, HMS, HPDL, hydroxymandelate synthase, hydroxyphenylpyruvate dioxygenase-like

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
                1.13.11.46 4-hydroxymandelate synthase

Reference

Reference on EC 1.13.11.46 - 4-hydroxymandelate synthase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Choroba, O.W.; Williams, D.H.; Spencer, J.B.
Biosynthesis of the vancomycin group of antibiotics: involvement of an unusual dioxygenase in the pathway to (S)-4-hydroxyphenylglycine
J. Am. Chem. Soc.
122
5389-5390
2000
Amycolatopsis orientalis
-
Manually annotated by BRENDA team
Brownlee, J.; He, P.; Moran, G.R.; Harrison, D.H.
Two roads diverged: the structure of hydroxymandelate synthase from Amycolatopsis orientalis in complex with 4-hydroxymandelate
Biochemistry
47
2002-2013
2008
Amycolatopsis orientalis
Manually annotated by BRENDA team
Conrad, J.A.; Moran, G.R.
The interaction of hydroxymandelate synthase with the 4-hydroxyphenylpyruvate dioxygenase inhibitor: NTBC
Inorg. Chim. Acta
361
1197-1201
2008
Amycolatopsis orientalis
Manually annotated by BRENDA team
Shah, D.D.; Conrad, J.A.; Heinz, B.; Brownlee, J.M.; Moran, G.R.
Evidence for the mechanism of hydroxylation by 4-hydroxyphenylpyruvate dioxygenase and hydroxymandelate synthase from intermediate partitioning in active site variants
Biochemistry
50
7694-7704
2011
Amycolatopsis orientalis
Manually annotated by BRENDA team
Wojcik, A.; Broclawik, E.; Siegbahn, P.E.; Borowski, T.
Mechanism of benzylic hydroxylation by 4-hydroxymandelate synthase. A computational study
Biochemistry
51
9570-9580
2012
Amycolatopsis orientalis
Manually annotated by BRENDA team
Shah, D.; Conrad, J.; Moran, G.
Intermediate partitioning kinetic isotope effects for the NIH shift of 4-hydroxyphenylpyruvate dioxygenase and the hydroxylation reaction of hydroxymandelate synthase reveal mechanistic complexity
Biochemistry
52
6097-6107
2013
Amycolatopsis orientalis
Manually annotated by BRENDA team
Di Giuro, C.M.; Konstantinovics, C.; Rinner, U.; Nowikow, C.; Leitner, E.; Straganz, G.D.
Chiral hydroxylation at the mononuclear nonheme Fe(II) center of 4-(S) hydroxymandelate synthase - a structure-activity relationship analysis
PLoS ONE
8
e68932
2013
Streptomyces coelicolor, Streptomyces coelicolor A3(2)
Manually annotated by BRENDA team
Banh, R.; Kim, E.; Spillier, Q.; Biancur, D.; Yamamoto, K.; Sohn, A.; Shi, G.; Jones, D.; Kimmelman, A.; Pacold, M.
The polar oxy-metabolome reveals the 4-hydroxymandelate CoQ10 synthesis pathway
Nature
597
420-425
2021
Homo sapiens (Q96IR7), Homo sapiens
Manually annotated by BRENDA team