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1.13.11.52: indoleamine 2,3-dioxygenase

This is an abbreviated version!
For detailed information about indoleamine 2,3-dioxygenase, go to the full flat file.

Word Map on EC 1.13.11.52

Reaction

D-tryptophan
+
O2
=
N-formyl-D-kynurenine

Synonyms

31854, BRAFLDRAFT_126354, CG5163, EC 1.13.1.12, hIDO, hIDO1, hTDO, IDO, IDO-1, IDO-2, IDO-I, IDO-II, IDO-III, IDO-IV, IDO1, IDO2, INDO, INDOL1, indolamine 2,3-dioxygenase, indole 2,3-dioxygenase, indoleamine 2, 3-dioxygenase, indoleamine 2,3 dioxygenase, indoleamine 2,3-dioxygenase, indoleamine 2,3-dioxygenase 1, indoleamine 2,3-dioxygenase 2, indoleamine 2,3-dioxygenase-1, indoleamine 2,3-dioxygenase-2, indoleamine 2,3-dioxygenase-like protein, indoleamine-2,3-dioxygenase, Indoleamine-pyrrole 2,3-dioxygenase, L-tryptophan 2,3-dioxygenase, L-tryptophan pyrrolase, mIDO, oxygenase, tryptophan 2,3-di-, proto-IDO, proto-indoleamine 2,3-dioxygenase, superoxygenase, TDO, TDO2, TioF, TO, TRPO, Tryptamin 2,3-dioxygenase, tryptamine 2,3-dioxygenase, tryptophan 2,3-dioxygenase, tryptophan dioxygenase, tryptophan oxygenase, tryptophan peroxidase, tryptophan pyrrolase, tryptophan-2,3-dioxygenase, tryptophanase, v1g244579, Vermilion protein

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
                1.13.11.52 indoleamine 2,3-dioxygenase

Expression

Expression on EC 1.13.11.52 - indoleamine 2,3-dioxygenase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
arachinoate and the prostaglandin metabolite, PGD2, repress the IFNgamma mediated activity of IDO-1 in THP-1 cells and human monocytes
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IDO activity is increased during severe sepsis and septic shock and is associated with mortality. IDO activity is maximal in culture after 3 days of interferon-gamma stimulation
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IDO expression in bone marrow-derived dendritic cells is increased by hemin, a potent inducer of heme oxygenase-1
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IDO expression is abrogated by the heme oxygenase inhibitor zinc protoporphrin (5 mg/kg, i.p.). Heme oxygenase-1 downregulation decreases lipopolysaccharide-induced IDO expression in murine dendritic cells. Lipopolysaccharide induces high IDO expression
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IDO expression is induced by interferon-gamma. IDO is detected when exposed to 100 units/ml IFN-gamma for 4 h and is enhanced by continuous exposure to IFN-gamma
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IDO expression is negatively regulated by interleukin-4, nitric oxide and transforming growth factor-beta
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IDO expression is not induced by interferon-alpha
IDO expression is positively regulated by interferon-gamma, CD40 ligand, COX-2, lipopolysaccharide, tumor necrosis factor-alpha, and hepatocyte growth factor
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IDO is an interferon-gamma-induced enzyme
IDO-1 levels are increased in Alzheimer's disease brains compared to controls
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IDO1 expression is upregulated by cytokines such as IFN-gamma, e.g. in HELA cells, IDO2 mRNA expression is upregulated in response to IFN-gamma in some cancer cell lines as well and human mesenchymal stem cells
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IDO1 expression is upregulated by cytokines such as IFN-gamma, IDO2 is upregulated in mouse dendritic cell lines as well as mouse mesenchymal stem cells. IDO2 mRNA is also upregulated in the brain of mice infected with Toxoplasma gondii, an infection in which IFN-gamma-driven responses play an important role in controlling parasite growth
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IFN-gamma stimulates the expression of indoleamine 2,3-dioxygenase
in mice heterozygous for the alpha-isoform of calcium/calmodulin-dependent protein kinase II, in which dentate gyrus granule cells fail to mature normally, TDO immunoreactivity is substantially downregulated in the dentate gyrus granule cells
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interferon-gamma induces the expression of indoleamine 2,3-dioxygenase, an 100fold and 200fold increase in IDO activity is detected with IFN-gamma concentrations of 5 and 10 units/ml, respectively
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isozyme IDO 1 (but not isozyme IDO2) is induced specifically in the lungs of mice infected with Francisella novicida or Streptococcus pneumonia
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recombinant transforming growth factor-beta1 of grass carp could up-regulate the expression of indoleamine 2,3-dioxygenase
sodium butyrate down-regulates indoleamine 2,3-dioxygenase at the transcriptional and post-transcriptional levels. Treatment with sodium butyrate (up to 0.2 mM) significantly reduces IDO induction, which is almost completely inhibited at a concentration of 0.5 mM. Sodium butyrate causes a ubiquitin-mediated proteasomal degradation process that contributes to degradation of IDO. Treatment with bortezomib significantly represses sodium butyrate-induced down-regulation of IDO protein
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suppressive effect of plant extracts or phytochemicals on IDO1 induction and activity
TDO expression gradually increases with the development of granule cells. new neurons begin to express TDO between 2 and 4 weeks after the neurons are generated, when the axons and dendrites of the granule cells develop and synaptogenesis occurs
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the enzyme is constitutively expressed in various tissues, and its expression can be significantly up-regulated by LPS and poly(I:C) in peripheral blood leukocytes
the enzyme is cytokine-inducible
the expression of TDO mRNA is significantly increased in the cerebellum of Alzheimer's disease mouse brain
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the methanol extracts of Myoga flower buds, which are traditional Japanese foods, and labdane-type diterpene galanal derived from Myoga flowers significantly suppress IDO1 activity
TLR9 ligand CpG, soluble CTLA4 or interferon-gamma induce IDO expression
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transient stimulation of the innate immune system by an intraperitoneal injection of lipopolysaccharide (100 ng) activates peripheral and central expression of indoleamine 2,3 dioxygenase. Addition of lipopolysaccharide (10 ng/ml) to the medium of organotypic hippocampal slice cultures induces steady-state expression of mRNA transcripts for IDO that peaks at 6 h and translates into increased IDO enzymatic activity within 8 h post-lipopolysaccharide
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treated with interferon gamma stimulates hIDO1 expression
treatment of Pax5iGFP/iGFP knockin mice with CpG oligonucleotides (CpG B 1826 with a fully phosphorothioate backbone, 0.1 mg, i.v.) induces IDO expression
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treatment with 1000 units/ml interferon-gamma increases the PDL-1 cell surface expression and the IDO activity
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treatment with 25 ng HIV-1 clade B Tat protein significantly upregulates IDO gene and protein expression 24 h after incubation compared to HIV-1 clade C Tat protein
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treatment with interferon-gamma (200 units/ml) induces expression of IDO
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