1.13.11.52: indoleamine 2,3-dioxygenase

This is an abbreviated version!
For detailed information about indoleamine 2,3-dioxygenase, go to the full flat file.

Reaction

Synonyms

31854, BRAFLDRAFT_126354, CG5163, EC 1.13.1.12, hIDO, hIDO1, hTDO, IDO, IDO-1, IDO-2, IDO-I, IDO-II, IDO-III, IDO-IV, IDO1, IDO2, INDO, INDOL1, indolamine 2,3-dioxygenase, indole 2,3-dioxygenase, indoleamine 2, 3-dioxygenase, indoleamine 2,3 dioxygenase, indoleamine 2,3-dioxygenase, indoleamine 2,3-dioxygenase 1, indoleamine 2,3-dioxygenase 2, indoleamine 2,3-dioxygenase-1, indoleamine 2,3-dioxygenase-2, indoleamine 2,3-dioxygenase-like protein, indoleamine-2,3-dioxygenase, Indoleamine-pyrrole 2,3-dioxygenase, L-tryptophan 2,3-dioxygenase, L-tryptophan pyrrolase, mIDO, oxygenase, tryptophan 2,3-di-, proto-IDO, proto-indoleamine 2,3-dioxygenase, superoxygenase, TDO, TDO2, TioF, TO, TRPO, Tryptamin 2,3-dioxygenase, tryptamine 2,3-dioxygenase, tryptophan 2,3-dioxygenase, tryptophan dioxygenase, tryptophan oxygenase, tryptophan peroxidase, tryptophan pyrrolase, tryptophan-2,3-dioxygenase, tryptophanase, v1g244579, Vermilion protein

ECTree

     1 Oxidoreductases

         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

             1.13.11 With incorporation of two atoms of oxygen

                1.13.11.52 indoleamine 2,3-dioxygenase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
73	Activating Compound
71	AA Sequence
32	Application
1	CAS Registry Number
89	Cloned(Commentary)
161	Cofactor
14	Crystallization (Commentary)
3561	Disease/ Diagnostics
31	Expression
98	General Information
6	General Stability
488	IC50 Value
906	Inhibitors
27	kcat/KM [mM/s]
94	Ki Value [mM]
209	KM Value [mM]
16	Localization
24	Metals/Ions
53	Molecular Weight [Da]
207	Natural Substrates/ Products (Substrates)
337	Organism
3	Oxidation Stability
9	Pathway
155	PDB ID
44	pH Optimum
7	pH Range
6	pH Stability
3	pI Value
5	Posttranslational Modification
48	Protein Variants
78	Purification (Commentary)
8	Reaction
4	Reaction Type
322	Reference
390	Source Tissue
108	Specific Activity [micromol/min/mg]
9	Storage Stability
501	Substrates and Products (Substrate)
48	Subunits
322	Synonyms
1	Systematic Name
23	Temperature Optimum [°C]
11	Temperature Stability [°C]
111	Turnover Number [1/s]

IC50 Value

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

IC50 Value on EC 1.13.11.52 - indoleamine 2,3-dioxygenase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to IC50 Value Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.0234

(-)-kurarinone

Homo sapiens

P14902

pH 6.5, 37°C

765149

-

0.00317

(1R,2S)-2-([[6-(trifluoromethyl)-1H-indazol-4-yl]amino]methyl)cyclohexan-1-ol

Homo sapiens

P14902

22°C, pH 6.5

765226

-

0.00123

(1R,2S)-2-[[(5-bromo-1H-indazol-4-yl)amino]methyl]cyclohexan-1-ol

Homo sapiens

P14902

22°C, pH 6.5

765226

-

0.03801

(1R,2S)-2-[[(5-bromo-1H-indazol-7-yl)amino]methyl]cyclohexan-1-ol

Homo sapiens

P14902

22°C, pH 6.5

765226

-

0.06604

(1R,2S)-2-[[(5-chloro-1H-indazol-7-yl)amino]methyl]cyclohexan-1-ol

Homo sapiens

P14902

22°C, pH 6.5

765226

-

0.00064

(1R,2S)-2-[[(6-bromo-1H-indazol-4-yl)amino]methyl]cyclohexan-1-ol

Homo sapiens

P14902

22°C, pH 6.5

765226

-

0.00578

(1R,2S)-2-[[(6-bromo-1H-indazol-4-yl)amino]methyl]cyclohexyl acetate

Homo sapiens

P14902

22°C, pH 6.5

765226

-

0.1783

(1R,2S)-2-[[(6-chloro-1H-indazol-4-yl)amino]methyl]cyclohexan-1-ol

Homo sapiens

P14902

22°C, pH 6.5

765226

-

0.00187

(1R,2S)-2-[[(6-methyl-1H-indazol-4-yl)amino]methyl]cyclohexan-1-ol

Homo sapiens

P14902

22°C, pH 6.5

765226

-

0.00285

(1S,2R)-2-[[(6-bromo-1H-indazol-4-yl)amino]methyl]cyclohexan-1-ol

Homo sapiens

P14902

22°C, pH 6.5

765226

-

0.0035

(2,4-dichlorophenyl)methanethiol

Homo sapiens

-

in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C

711422

0.0012

(2-chlorophenyl)methanethiol

Homo sapiens

-

in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C

711422

0.00012

(2E)-3-(8-fluoro-6,12-dioxo-6,12-dihydroindolo[2,1-b]quinazolin-2-yl)prop-2-enoic acid

Homo sapiens

P14902

pH and temperature not specified in the publication

764295

-

0.0314

(2S)-2'-methoxy kurarinone

Homo sapiens

P14902

pH 6.5, 37°C

765149

-

0.0001

(3,4-dichlorophenyl)methanethiol

Homo sapiens

-

in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C

711422

0.5

(3-hydroxyphenyl)(phenyl)methanone

Homo sapiens

P14902

in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C

712694

0.000512

(3R,4S and 3S,4R)-3-bromo-4-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione

Homo sapiens

P14902

-

699424

0.000361

(3R,4S and 3S,4R)-3-hydroxy-2,2-dimethyl-4-morpholino-3,4-dihydro-2H-benzo[g]chromene-5,10-dione

Homo sapiens

P14902

-

699424

0.00396

(3R,4S and 3S,4R)-3-hydroxy-4-methoxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione

Homo sapiens

P14902

-

699424

0.000183

(3R,4S and 3S,4R)-4-(allylamino)-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione

Homo sapiens

P14902

-

699424

0.000252

(3R,4S and 3S,4R)-4-(benzylamino)-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione

Homo sapiens

P14902

-

699424

0.00345

(3R,4S and 3S,4R)-4-(benzylthio)-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione

Homo sapiens

P14902

-

699424

0.000082

(3R,4S and 3S,4R)-4-(butylamino)-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione

Homo sapiens

P14902

-

699424

0.0015

(3S,4S and 3R,4R)-3,4-dihydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione

Homo sapiens

P14902

alpha-lapachone

699424

0.0011

(3S,4S and 3R,4R)-3-hydroxy-2,2-dimethyl-4-morpholino-3,4-dihydro-2H-benzo[g]chromene-5,10-dione

Homo sapiens

P14902

-

699424

0.000976

(3S,4S and 3R,4R)-3-hydroxy-4-methoxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione

Homo sapiens

P14902

-

699424

0.000186

(3S,4S and 3R,4R)-4-(allylamino)-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione

Homo sapiens

P14902

-

699424

0.000055

(3S,4S and 3R,4R)-4-(benzylamino)-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione

Homo sapiens

P14902

-

699424

0.00109

(3S,4S and 3R,4R)-4-(benzyloxy)-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione

Homo sapiens

P14902

-

699424

0.00212

(3S,4S and 3R,4R)-4-(benzylthio)-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione

Homo sapiens

P14902

-

699424

0.00013

(3S,4S)-4-(butylamino)-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione

Homo sapiens

P14902

-

699424

0.0032

(4-chlorophenyl)methanethiol

Homo sapiens

-

in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C

711422

0.1

(4-chlorophenyl)methanol

Homo sapiens

-

IC50 above 0.1 mM, in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C

711422

0.0018

(4-fluorophenyl)methanethiol

Homo sapiens

-

in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C

711422

0.0014

(4-methoxyphenyl)methanethiol

Homo sapiens

-

in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C

711422

0.0013

(4-methylphenyl)methanethiol

Homo sapiens

-

in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C

711422

0.00045

(4E,4'E)-4,4'-bis(isopropylimino)-2,2'-binaphthyl-1,1'-(4H,4'H)-dione

Homo sapiens

P14902

in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C

712694

0.00052

(4E,4'E)-4,4'-bis(pentan-3-ylimino)-2,2'-binaphthyl-1,1'-(4H,4'H)-dione

Homo sapiens

P14902

in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C

712694

0.00179

(8-fluoro-6,12-dioxo-6,12-dihydroindolo[2,1-b]quinazolin-2-yl)boronic acid

Homo sapiens

P14902

pH and temperature not specified in the publication

764295

-

0.0002

(E)-4-(isopropylimino)-2-methylnaphthalen-1(4H)-one

Homo sapiens

P14902

in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C

712694

0.09

(R)-2-amino-N-(4-hydroxynaphth-1-yl)propanamide

Homo sapiens

P14902

in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C

712694

0.00034

(S)-2-amino-5-((R)-1-(carboxymethylamino)-3-(1,4-dihydroxy-3-methylnaphthalen-2-ylthio)-1-oxopropan-2-ylamino)-5-oxopentanoic acid

Homo sapiens

P14902

-

699424

0.00088

(S)-2-amino-5-((R)-1-(carboxymethylamino)-3-(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-ylthio)-1-oxopropan-2-ylamino)-5-oxopentanoic acid

Homo sapiens

P14902

-

699424

0.06

(S)-2-amino-N-(4-hydroxynaphth-1-yl)propanamide

Homo sapiens

P14902

in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C

712694

0.0071

1,2-naphthoquinone

Homo sapiens

P14902

-

699424

0.00099

1,4-naphtho-quinone

Homo sapiens

P14902

-

699424

0.0293

1,6,6-trimethyl-10,11-dioxo-2-(thiophen-3-yl)-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl propanoate

Homo sapiens

P14902

37°C, pH 6.5

765415

-

0.0215

1,6,6-trimethyl-10,11-dioxo-2-phenyl-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl propanoate

Homo sapiens

P14902

37°C, pH 6.5

765415

-

0.00571

1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl 1,3-thiazole-2-carboxylate

Homo sapiens

P14902

37°C, pH 6.5

765415

-

0.00372

1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl acetate

Homo sapiens

P14902

37°C, pH 6.5

765415

-

0.00705

1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl cyclopropanecarboxylate

Homo sapiens

P14902

37°C, pH 6.5

765415

-

0.0046

1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl furan-3-carboxylate

Homo sapiens

P14902

37°C, pH 6.5

765415

-

0.00274

1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl hydroxyacetate

Homo sapiens

P14902

37°C, pH 6.5

765415

-

0.00472

1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl propanoate

Homo sapiens

P14902

37°C, pH 6.5

765415

-

0.00084

1,6,6-trimethylphenanthro[1,2-b]furan-7,10,11(6H)-trione

Homo sapiens

P14902

37°C, pH 6.5

765415

-

0.05

1-(1,3-benzothiazol-2-ylsulfanyl)-N,N-dimethylmethanamine

Homo sapiens

P14902

in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C

712694

0.000809

1-(2-methylbenzyl)-1H-naphtho[2,3-d][1,2,3]triazole-4,9-dione

Homo sapiens

P14902

pH 8.0, 37°C

743064

0.003163

1-(3-bromobenzyl)-1H-naphtho[2,3-d][1,2,3]triazole-4,9-dione

Homo sapiens

P14902

pH 8.0, 37°C

743064

0.000767

1-(3-chlorobenzyl)-1H-naphtho[2,3-d][1,2,3]triazole-4,9-dione

Homo sapiens

P14902

pH 8.0, 37°C

743064

0.000602

1-(3-[(4-acetyl-1-piperazinyl)carbonyl]benzyl)-1H-naphtho-[2,3-d][1,2,3]triazole-4,9-dione

Homo sapiens

P14902

pH 8.0, 37°C

743064

0.00064

1-(3-[(4-methyl-1-piperazinyl)carbonyl]benzyl)-1H-naphtho-[2,3-d][1,2,3]triazole-4,9-dione

Homo sapiens

P14902

pH 8.0, 37°C

743064

0.01

1-(4-bromobenzyl)-1H-naphtho[2,3-d][1,2,3]triazole-4,9-dione

Homo sapiens

P14902

above, pH 8.0, 37°C

743064

0.000339

1-(4-bromophenyl)-2-[[5-(4-chlorophenyl)[1,3]thiazolo[2,3-c]-[1,2,4]triazol-3-yl]sulfanyl]ethanone

Homo sapiens

P14902

pH and temperature not specified in the publication

765223

-

0.1

1-(4-chlorobenzyl)urea

Homo sapiens

-

IC50 above 0.1 mM, in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C

711422

0.1

1-(4-chlorophenyl)methanamine

Homo sapiens

-

IC50 above 0.1 mM, in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C

711422

0.1

1-(4-chlorophenyl)thiourea

Homo sapiens

-

IC50 above 0.1 mM, in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C

711422

0.0000164

1-(4-cyanophenyl)-3-(3-(cyclopropylethynyl)imidazo[2,1-b]thiazol-5-yl)thiourea

Homo sapiens

P14902

pH and temperature not specified in the publication

765223

-

0.002587

1-(4-fluorobenzyl)-1H-naphtho[2,3-d][1,2,3]triazole-4,9-dione

Homo sapiens

P14902

pH 8.0, 37°C

743064

0.00177

1-(4-methylbenzyl)-1H-naphtho[2,3-d][1,2,3]triazole-4,9-dione

Homo sapiens

P14902

pH 8.0, 37°C

743064

0.001097

1-(4-[(4-acetylpiperazin-1-yl)carbonyl]benzyl)-1H-naphtho-[2,3-d][1,2,3]triazole-4,9-dione

Homo sapiens

P14902

pH 8.0, 37°C

743064

0.001593

1-(4-[(4-methoxypiperidin-1-yl)carbonyl]benzyl)-1Hnaphtho[2,3-d][1,2,3]triazole-4,9-dione

Homo sapiens

P14902

pH 8.0, 37°C

743064

0.00037

1-(hydroxymethyl)-6,6-dimethylphenanthro[1,2-b]furan-7,10,11(6H)-trione

Homo sapiens

P14902

37°C, pH 6.5

765415

-

0.032

1-benzyl-5-phenyl-1H-imidazole

Homo sapiens

P14902

-

699438

0.000081

1-cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethan-1-ol

Homo sapiens

P14902

22°C, pH 6.5

765226

0.4233

1-methyl-tryptophan

Homo sapiens

P14902

pH 6.5, 37°C

765149

0.004612

1-[(3-methylphenyl)methyl]-1H-naphtho[2,3-d][1,2,3]triazole-4,9-dione

Homo sapiens

P14902

pH 8.0, 37°C

743064

0.01

1-[(4-chlorophenyl)methyl]-1H-naphtho[2,3-d][1,2,3]triazole-4,9-dione

Homo sapiens

P14902

above, pH 8.0, 37°C

743064

0.00057

1-[(8-fluoro-6,12-dioxo-6,12-dihydroindolo[2,1-b]quinazolin-2-yl)methyl]piperidine-3-carboxylic acid

Homo sapiens

P14902

pH and temperature not specified in the publication

764295

-

0.00048

1-[(8-fluoro-6,12-dioxo-6,12-dihydroindolo[2,1-b]quinazolin-2-yl)methyl]piperidine-4-carboxylic acid

Homo sapiens

P14902

pH and temperature not specified in the publication

764295

-

0.00055

1-[(8-fluoro-6,12-dioxo-6,12-dihydroindolo[2,1-b]quinazolin-2-yl)methyl]proline

Homo sapiens

P14902

pH and temperature not specified in the publication

764295

-

0.1

1-[2-(4-chlorophenyl)ethyl]thiourea

Homo sapiens

-

in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C

711422

0.000936

1-[3-(4-morpholinylcarbonyl)benzyl]-1H-naphtho[2,3-d]-[1,2,3]triazole-4,9-dione

Homo sapiens

P14902

pH 8.0, 37°C

743064

0.000982

1-[4-(morpholin-4-ylcarbonyl)benzyl]-1H-naphtho[2,3-d]-[1,2,3]triazole-4,9-dione

Homo sapiens

P14902

pH 8.0, 37°C

743064

0.002069

1-[4-[(4-methylpiperazin-1-yl)carbonyl]benzyl]-1H-naphtho-[2,3-d][1,2,3]triazole-4,9-dione

Homo sapiens

P14902

pH 8.0, 37°C

743064

0.000028

1-[4-[bis(2-methylpropyl)amino]-2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-3-yl]-3-(4-methylphenyl)imidazolidin-2-one

Homo sapiens

P14902

pH and temperature not specified in the publication, cellular assay of kynurenine production

764292

-

0.0044 - 0.013

15-deoxy-DELTA12,14-prostaglandin

2 entries

2.57

1H-benzotriazole

Homo sapiens

-

pH 6.5, 37°C, recombinant enzyme

724912

0.00495

2,2-dimethyl-1a,9b-dihydro-2H-benzo[g]oxireno[c]chromene-4,9-dione

Homo sapiens

P14902

pH and temperature not specified in the publication

711910

0.000214

2,2-dimethyl-2H-benzo[g]chromene-5,10-dione

Homo sapiens

P14902

dehydro-alpha-lapachone

699424

0.00434

2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione

Homo sapiens

P14902

-

699424

0.00495

2,2-dimethyl-3,4-epoxy-2H-naphtho[2,3-b]pyran-5,10-dione

Homo sapiens

P14902

-

699424

0.00028

2,3-dichloro-1,4-naphthoquinone

Homo sapiens

P14902

-

699424

0.0004

2,4-dichlorobenzyl carbamimidothioate hydrobromide

Homo sapiens

-

in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C

711422

0.0053

2-(1H-imidazol-4-yl)benzene-1,3-diol

Homo sapiens

P14902

-

699438

0.025

2-(1H-imidazol-4-yl)benzenethiol

Homo sapiens

P14902

-

699438

0.0048

2-(1H-imidazol-4-yl)phenol

Homo sapiens

P14902

-

699438

0.035

2-(1H-pyrazol-3-yl)phenol

Homo sapiens

P14902

-

699438

0.1

2-(2-chlorophenyl)ethyl carbamimidothioate hydrobromide

Homo sapiens

-

IC50 above 0.1 mM, in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C

711422

0.1

2-(3-chlorophenyl)ethyl carbamimidothioate hydrobromide

Homo sapiens

-

IC50 above 0.1 mM, in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C

711422

0.1

2-(4-chlorophenyl)ethanamine

Homo sapiens

-

IC50 above 0.1 mM, in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C

711422

0.057

2-(4-chlorophenyl)ethyl carbamimidothioate hydrobromide

Homo sapiens

-

in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C

711422

0.000922

2-(4-[(4,9-dioxo-4,9-dihydro-1H-naphtho[2,3-d][1,2,3]-triazol-1-yl)methyl]phenyl)-N,N-diethylacetamide

Homo sapiens

P14902

pH 8.0, 37°C

743064

0.25

2-([5-(3-methoxyphenyl)[1,3]thiazolo[2,3-c][1,2,4]triazol-3-yl]sulfanyl)-N-(5-methyl-1,3-thiazol-2-yl)acetamide

2 entries

0.00087

2-([[3-(4-bromophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methyl]amino)-2-oxoethyl (2-hydroxyphenyl)acetate

Homo sapiens

P14902

pH and temperature not specified in the publication

764291

-

0.00034

2-([[3-(4-bromophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methyl]amino)-2-oxoethyl (4-cyanophenyl)acetate

Homo sapiens

P14902

pH and temperature not specified in the publication

764291

-

0.0002

2-([[3-(4-bromophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methyl]amino)-2-oxoethyl (4-hydroxyphenyl)acetate

Homo sapiens

P14902

pH and temperature not specified in the publication

764291

-

0.00058

2-([[3-(4-bromophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methyl]amino)-2-oxoethyl phenylacetate

Homo sapiens

P14902

pH and temperature not specified in the publication

764291

-

0.4

2-amino-3-hydroxy-N-(4-hydroxynaphthalen-1-yl)propanamide

Homo sapiens

P14902

in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C

712694

0.105

2-amino-N-(4-hydroxynaphth-1-yl)acetamide

Homo sapiens

P14902

in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C

712694

0.01

2-chlorobenzyl carbamimidothioate hydrochloride

Homo sapiens

-

in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C

711422

0.675

2-Hydroxy-1,4-naphthoquinone

Homo sapiens

P14902

-

699424

0.05

2-mercaptobenzothiazole

Homo sapiens

P14902

in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C

712694

0.00072

2-methoxy-1,4-naphthoquinone

Homo sapiens

P14902

-

699424

0.0011

2-methyl-1,4-naphthoquinone

Homo sapiens

P14902

-

699424

0.0011

2-methylnaphthalene-1,4-dione

Homo sapiens

P14902

pH and temperature not specified in the publication

711910

1

2-phenoxyaniline

Homo sapiens

P14902

IC50 above 1.0 mM, in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C

712694

0.01309

2-[(6-bromo-1H-indazol-4-yl)amino]-1-(3-chlorophenyl)ethan-1-ol

Homo sapiens

P14902

22°C, pH 6.5

765226

-

0.1371

2-[(6-bromo-1H-indazol-4-yl)amino]-1-(4-hydroxyphenyl)ethan-1-one

Homo sapiens

P14902

22°C, pH 6.5

765226

-

0.01833

2-[(6-bromo-1H-indazol-4-yl)amino]-2-(3-chlorophenyl)ethan-1-ol

Homo sapiens

P14902

22°C, pH 6.5

765226

-

0.04287

2-[(6-bromo-1H-indazol-4-yl)amino]-2-phenylethan-1-ol

Homo sapiens

P14902

22°C, pH 6.5

765226

-

0.0000787

2-[([4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]carbamoyl)amino]benzoic acid

Homo sapiens

P14902

pH and temperature not specified in the publication

764273

-

0.00412

2-[[(6-bromo-1H-indazol-4-yl)amino]methyl]cyclohexan-1-ol

Homo sapiens

P14902

22°C, pH 6.5

765226

-

0.000022

3'-[[(2-chlorophenyl)carbamoyl]amino]-4-methoxy-4'-[(5,6,7,8-tetrahydronaphthalen-1-yl)oxy][1,1'-biphenyl]-3-carboxylic acid

Homo sapiens

P14902

pH and temperature not specified in the publication, cellular assay of kynurenine production

764287

-

0.00005

3'-[[(2-fluorophenyl)carbamoyl]amino]-4-methoxy-4'-[(5,6,7,8-tetrahydronaphthalen-1-yl)oxy][1,1'-biphenyl]-3-carboxylic acid

Homo sapiens

P14902

pH and temperature not specified in the publication, cellular assay of kynurenine production

764287

-

0.000042

3'-[[(4-methylphenyl)carbamoyl]amino]-4'-[(2-methylpropyl)(propan-2-yl)amino][1,1'-biphenyl]-2-carboxylic acid

Homo sapiens

P14902

pH and temperature not specified in the publication, cellular assay of kynurenine production

764292

-

0.000159

3'-[[(4-methylphenyl)carbamoyl]amino]-4'-[(4aS,8aS)-octahydroquinolin-1(2H)-yl][1,1'-biphenyl]-2-carboxylic acid

Homo sapiens

P14902

pH and temperature not specified in the publication, cellular assay of kynurenine production

764292

-

0.017

3,4-dichlorobenzyl carbamimidothioate hydrochloride

Homo sapiens

-

in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C

711422

0.68 - 0.708

3-(1H-1,2,3-triazol-5-yl)pyridine

2 entries

0.825

3-(1H-imidazol-4-yl)benzaldehyde

2 entries

0.0076

3-(1H-imidazol-4-yl)benzenethiol

Homo sapiens

P14902

-

699438

0.041

3-(1H-imidazol-4-yl)benzonitrile

Homo sapiens

P14902

-

699438

0.365

3-(1H-imidazol-4-yl)phenol

Homo sapiens

P14902

-

699438

0.00051

3-(2-aminoethyl)-5-(pyridin-3-yl)-1H-indole-4,7-dione

Homo sapiens

P14902

pH and temperature not specified in the publication

764294

-

0.000379

3-(4-bromophenyl)imidazo[2,1-b][1,3]thiazole

Homo sapiens

P14902

pH and temperature not specified in the publication

765223

-

0.0077

3-(4H-imidazol-4-yl)benzenethiol

Homo sapiens

P14902

-

699438

0.0046

3-chlorobenzyl carbamimidothioate hydrochloride

Homo sapiens

-

in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C

711422

0.00036

3-hydroxy-2,2-dimethyl-4-(morpholin-4-yl)-3,4-dihydro-2H-benzo[g]chromene-5,10-dione

Homo sapiens

P14902

pH and temperature not specified in the publication

711910

0.00396

3-hydroxy-4-methoxy-2,2-dimethyl-2H-benzo[g]chromene-5,10-dione

Homo sapiens

P14902

pH and temperature not specified in the publication

711910

0.161

3-phenylpyridine

Homo sapiens

P14902

-

699438

0.000977

3-[(4,9-dioxo-4,9-dihydro-1H-naphtho[2,3-d][1,2,3]triazol-1-yl)methyl]-N,N-diethylbenzamide

Homo sapiens

P14902

pH 8.0, 37°C

743064

0.001242

3-[(4,9-dioxo-4,9-dihydro-1H-naphtho[2,3-d][1,2,3]triazol-1-yl)methyl]benzoic acid

Homo sapiens

P14902

pH 8.0, 37°C

743064

0.000065

3-[([4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]carbamoyl)amino]benzoic acid

Homo sapiens

P14902

pH and temperature not specified in the publication

764273

-

0.0015

3-[2-(cyclohexylamino)ethyl]-5-(pyridin-3-yl)-1H-indole-4,7-dione

Homo sapiens

P14902

pH and temperature not specified in the publication

764294

-

0.00226

3-[2-(diethylamino)ethyl]-5-(pyridin-3-yl)-1H-indole-4,7-dione

Homo sapiens

P14902

pH and temperature not specified in the publication

764294

-

0.0005

3-[2-(dimethylamino)ethyl]-5-(pyridin-3-yl)-1H-indole-4,7-dione

Homo sapiens

P14902

pH and temperature not specified in the publication

764294

-

0.00016

3-[2-(ethylamino)ethyl]-5-(pyridin-3-yl)-1H-indole-4,7-dione

Homo sapiens

P14902

pH and temperature not specified in the publication

764294

-

0.00088

3-[2-(propylamino)ethyl]-5-(pyridin-3-yl)-1H-indole-4,7-dione

Homo sapiens

P14902

pH and temperature not specified in the publication

764294

-

0.00056

3-[2-(tert-butylamino)ethyl]-5-(pyridin-3-yl)-1H-indole-4,7-dione

Homo sapiens

P14902

pH and temperature not specified in the publication

764294

-

0.004

3-[2-[(2-phenylethyl)amino]ethyl]-5-(pyridin-3-yl)-1H-indole-4,7-dione

Homo sapiens

P14902

pH and temperature not specified in the publication

764294

-

0.00051

3-[2-[(propan-2-yl)amino]ethyl]-5-(pyridin-3-yl)-1H-indole-4,7-dione

Homo sapiens

P14902

pH and temperature not specified in the publication

764294

-

0.000141

3-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]propanoic acid

Homo sapiens

P14902

pH and temperature not specified in the publication

742073

0.00016

4'-(2,3-dimethylphenoxy)-4-methoxy-3'-[[(4-methylphenyl)carbamoyl]amino][1,1'-biphenyl]-3-carboxylic acid

Homo sapiens

P14902

pH and temperature not specified in the publication, cellular assay of kynurenine production

764287

-

0.0024

4'-(2-chlorophenoxy)-3'-([[4-(2-hydroxypropan-2-yl)phenyl]carbamoyl]amino)-4-methoxy[1,1'-biphenyl]-3-carboxylic acid

Homo sapiens

P14902

pH and temperature not specified in the publication, cellular assay of kynurenine production

764287

-

0.00083

4'-(2-chlorophenoxy)-3'-[[(4-chlorophenyl)carbamoyl]amino]-4-methoxy[1,1'-biphenyl]-3-carboxylic acid

Homo sapiens

P14902

pH and temperature not specified in the publication, cellular assay of kynurenine production

764287

-

0.006

4'-(2-chlorophenoxy)-3'-[[(4-cyanophenyl)carbamoyl]amino]-4-methoxy[1,1'-biphenyl]-3-carboxylic acid

Homo sapiens

P14902

pH and temperature not specified in the publication, cellular assay of kynurenine production

764287

-

0.0021

4'-(2-chlorophenoxy)-4-methoxy-3'-[[(4-methoxyphenyl)carbamoyl]amino][1,1'-biphenyl]-3-carboxylic acid

Homo sapiens

P14902

pH and temperature not specified in the publication, cellular assay of kynurenine production

764287

-

0.00084

4'-(2-chlorophenoxy)-4-methoxy-3'-[[(4-methylphenyl)carbamoyl]amino][1,1'-biphenyl]-3-carboxylic acid

Homo sapiens

P14902

pH and temperature not specified in the publication, cellular assay of kynurenine production

764287

-

0.00054

4'-(2-ethylphenoxy)-4-methoxy-3'-[[(4-methylphenyl)carbamoyl]amino][1,1'-biphenyl]-3-carboxylic acid

Homo sapiens

P14902

pH and temperature not specified in the publication, cellular assay of kynurenine production

764287

-

0.0006

4'-(2-tert-butylanilino)-3'-[[(4-methylphenyl)carbamoyl]amino][1,1'-biphenyl]-2-carboxylic acid

Homo sapiens

P14902

pH and temperature not specified in the publication, cellular assay of kynurenine production

764292

-

0.0045

4'-(2-tert-butylphenoxy)-2-fluoro-3'-[[(4-methylphenyl)carbamoyl]amino][1,1'-biphenyl]-3-carboxylic acid

Homo sapiens

P14902

pH and temperature not specified in the publication, cellular assay of kynurenine production

764287

-

0.00007

4'-(2-tert-butylphenoxy)-3'-[[(4-methylphenyl)carbamoyl]amino][1,1'-biphenyl]-2-carboxylic acid

Homo sapiens

P14902

pH and temperature not specified in the publication, cellular assay of kynurenine production

764292

-

0.0024

4'-(2-tert-butylphenoxy)-4-chloro-3'-[[(4-methylphenyl)carbamoyl]amino][1,1'-biphenyl]-3-carboxylic acid

Homo sapiens

P14902

pH and temperature not specified in the publication, cellular assay of kynurenine production

764287

-

0.00012

4'-(2-tert-butylphenoxy)-4-ethoxy-3'-[[(4-methylphenyl)carbamoyl]amino][1,1'-biphenyl]-3-carboxylic acid

Homo sapiens

P14902

pH and temperature not specified in the publication, cellular assay of kynurenine production

764287

-

0.00035

4'-(2-tert-butylphenoxy)-4-methoxy-3'-[[(4-methylphenyl)carbamoyl]amino][1,1'-biphenyl]-3-carboxylic acid

Homo sapiens

P14902

pH and temperature not specified in the publication, cellular assay of kynurenine production

764287

-

0.00025

4'-(2-tert-butylphenoxy)-5-chloro-3'-[[(4-methylphenyl)carbamoyl]amino][1,1'-biphenyl]-3-carboxylic acid

Homo sapiens

P14902

pH and temperature not specified in the publication, cellular assay of kynurenine production

764287

-

0.00069

4'-(3-tert-butylphenoxy)-4-methoxy-3'-[[(4-methylphenyl)carbamoyl]amino][1,1'-biphenyl]-3-carboxylic acid

Homo sapiens

P14902

pH and temperature not specified in the publication, cellular assay of kynurenine production

764287

-

0.000504

4'-(cyclohexylamino)-3'-[[(4-methylphenyl)carbamoyl]amino][1,1'-biphenyl]-2-carboxylic acid

Homo sapiens

P14902

pH and temperature not specified in the publication, cellular assay of kynurenine production

764292

-

0.000045

4'-(dibutylamino)-3'-[[(4-methylphenyl)carbamoyl]amino][1,1'-biphenyl]-2-carboxylic acid

Homo sapiens

P14902

pH and temperature not specified in the publication, cellular assay of kynurenine production

764292

-

0.00028

4'-[(2,3-dihydro-1H-inden-4-yl)oxy]-4-methoxy-3'-[[(4-methylphenyl)carbamoyl]amino][1,1'-biphenyl]-3-carboxylic acid

Homo sapiens

P14902

pH and temperature not specified in the publication, cellular assay of kynurenine production

764287

-

0.000013

4'-[bis(2-methylpropyl)amino]-3'-[[(4-methylphenyl)carbamoyl]amino][1,1'-biphenyl]-2-carboxylic acid

Homo sapiens

P14902

pH and temperature not specified in the publication, cellular assay of kynurenine production

764292

-

0.000661

4'-[bis(2-methylpropyl)amino]-N-(methanesulfonyl)-3'-[[(4-methylphenyl)carbamoyl]amino][1,1'-biphenyl]-2-carboxamide

Homo sapiens

P14902

pH and temperature not specified in the publication, cellular assay of kynurenine production

764292

-

0.000348

4'-[bis(cyclopropylmethyl)amino]-3'-[[(4-methylphenyl)carbamoyl]amino][1,1'-biphenyl]-2-carboxylic acid

Homo sapiens

P14902

pH and temperature not specified in the publication, cellular assay of kynurenine production

764292

-

0.000014

4'-[cyclohexyl(methyl)amino]-3'-[[(4-methylphenyl)carbamoyl]amino][1,1'-biphenyl]-2-carboxylic acid

Homo sapiens

P14902

pH and temperature not specified in the publication, cellular assay of kynurenine production

764292

-

0.000023

4'-[cyclopentyl(ethyl)amino]-3'-[[(4-methylphenyl)carbamoyl]amino][1,1'-biphenyl]-2-carboxylic acid

Homo sapiens

P14902

pH and temperature not specified in the publication, cellular assay of kynurenine production

764292

-

0.005

4-(1H-1,2,3-triazol-5-yl)pyridine

Homo sapiens

P14902

in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C

712694

1.2

4-(1H-imidazol-4-yl)phenol

Homo sapiens

P14902

-

699438

0.734

4-(2,6-dimethoxyphenyl)-1H-imidazole

Homo sapiens

P14902

-

699438

0.003

4-(2-(diethylamino)ethylamino)-1-naphthol

Homo sapiens

P14902

in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C

712694

0.038

4-(2-(methylthio)phenyl)-1H-imidazole

Homo sapiens

P14902

-

699438

0.179

4-(2-fluorophenyl)-1H-imidazole

2 entries

0.0125

4-(2-hydroxyethoxy)-1-naphthol

Homo sapiens

P14902

in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C

712694

0.073

4-(3-(methylthio)phenyl)-1H-imidazole

Homo sapiens

P14902

-

699438

0.00033

4-(3-chlorophenyl)-imidazole

Homo sapiens

P14902, Q6ZQW0

pH and temperature not specified in the publication

765516

-

0.06

4-(3-fluorophenyl)-1H-imidazole

Homo sapiens

P14902

-

699438

0.209

4-(4-(methylthio)phenyl)-1H-imidazole

Homo sapiens

P14902

-

699438

0.0034

4-(4-bromophenyl)-1,3-thiazole-2(3H)-thione

Homo sapiens

P14902

pH 6.5, 22°C

764286

-

0.0026

4-(4-chlorophenyl)-1,3-thiazole-2(3H)-thione

Homo sapiens

P14902

pH 6.5, 22°C

764286

-

0.123

4-(4-fluorophenyl)-1H-imidazole

Homo sapiens

P14902

-

699438

0.0059

4-(4-methylphenyl)-1,3-thiazole-2(3H)-thione

Homo sapiens

P14902

pH 6.5, 22°C

764286

-

0.0025

4-(benzylamino)-1-naphthol

Homo sapiens

P14902

in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C

712694

0.000055 - 0.00025

4-(benzylamino)-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione

2 entries

0.00013

4-(butylamino)-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione

Homo sapiens

P14902

pH and temperature not specified in the publication

711910

0.015

4-(cyclohexylamino)-1-naphthol

Homo sapiens

P14902

in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C

712694

1

4-(dimethylamino)naphthalen-1-ol

Homo sapiens

P14902

in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C

712694

0.016

4-(ethylamino)-1-naphthol

Homo sapiens

P14902

in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C

712694

0.025

4-(isobutylamino)-1-naphthol

Homo sapiens

P14902

in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C

712694

0.0025

4-(isopropylamino)-1-naphthol

Homo sapiens

P14902

in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C

712694

0.000043

4-(methanesulfonyl)-N'-(3-methylphenyl)benzene-1-sulfonohydrazide

Homo sapiens

P14902

pH and temperature not specified in the publication

742073

0.0125

4-(methylamino)naphthalen-1-ol

Homo sapiens

P14902

in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C

712694

0.0035

4-(pent-3-ylamino)-1-naphthol

Homo sapiens

P14902

in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C

712694

0.1

4-(phenylcarbonyl)benzyl carbamimidothioate hydrobromide

Homo sapiens

-

IC50 above 0.1 mM, in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C

711422

0.1

4-(propan-2-yl)benzyl carbamimidothioate hydrobromide

Homo sapiens

-

IC50 above 0.1 mM, in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C

711422

0.0045

4-(propylamino)-1-naphthol

Homo sapiens

P14902

in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C

712694

0.004

4-(tert-butylamino)naphthalen-1-ol

Homo sapiens

P14902

in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C

712694

0.422

4-(thiophen-2-yl)-1H-imidazole

2 entries

0.0026

4-(trifluoromethyl)benzyl carbamimidothioate hydrochloride

Homo sapiens

-

in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C

711422

0.03022

4-([[(1S,2R)-2-hydroxycyclohexyl]methyl]amino)-1H-indazole-6-carboxylic acid

Homo sapiens

P14902

22°C, pH 6.5

765226

-

0.003

4-amino-1-naphthol

Homo sapiens

P14902

in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C

712694

0.0021

4-amino-N'-hydroxy-N-(3-isopropylphenyl)-1,2,5-oxadiazole-3-carboximidamide

Homo sapiens

-

-

699473

0.0044

4-amino-N'-hydroxy-N-(3-methoxyphenyl)-1,2,5-oxadiazole-3-carboximidamide

Homo sapiens

-

-

699473

0.00055

4-amino-N'-hydroxy-N-(3-methylphenyl)-1,2,5-oxadiazole-3-carboximidamide

Homo sapiens

-

-

699473

0.0032

4-amino-N'-hydroxy-N-phenyl-1,2,5-oxadiazole-3-carboximidamide

Homo sapiens

-

-

699473

0.0065

4-amino-N-(2-chlorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide

Homo sapiens

-

-

699473

0.000059

4-amino-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide

Homo sapiens

-

-

699473

0.000073

4-amino-N-(3-bromophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide

Homo sapiens

-

-

699473

0.000067

4-amino-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide

Homo sapiens

-

-

699473

0.0014

4-amino-N-(3-chlorophenyl)-1,2,5-oxadiazole-3-carbohydrazonamide

Homo sapiens

-

-

699473

0.000086

4-amino-N-(3-chlorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide

Homo sapiens

-

-

699473

0.00043

4-amino-N-(3-ethylphenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide

Homo sapiens

-

-

699473

0.0005

4-amino-N-(3-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide

Homo sapiens

-

-

699473

0.025

4-amino-N-(3-tert-butylphenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide

Homo sapiens

-

-

699473

0.006

4-amino-N-(4-chlorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide

Homo sapiens

-

-

699473

1.028

4-bromo-5-(4-methylphenyl)-1H-1,2,3-triazole

Homo sapiens

-

pH 6.5, 37°C, recombinant enzyme

724912

0.000085

4-bromo-N'-(4-bromophenyl)benzene-1-sulfonohydrazide

Homo sapiens

P14902

pH and temperature not specified in the publication

742073

0.0013

4-bromobenzyl carbamimidothioate hydrobromide

Homo sapiens

-

in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C

711422

0.1

4-chlorobenzenesulfonic acid

Homo sapiens

-

IC50 above 0.1 mM, in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C

711422

0.0019

4-chlorobenzenethiol

Homo sapiens

-

in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C

711422

0.0022

4-chlorobenzyl carbamimidothioate hydrochloride

Homo sapiens

-

in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C

711422

0.021

4-chlorobenzyl N,N'-dimethylcarbamimidothioate - 1-chlorotetraoxidane (1:1)

Homo sapiens

-

in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C

711422

0.00011

4-chlorophenyl-1,2,3-triazol-4-amine

Homo sapiens

P14902, Q6ZQW0

pH and temperature not specified in the publication

765516

-

0.000059

4-cyano-N'-(3-methylphenyl)benzene-1-sulfonohydrazide

Homo sapiens

P14902

pH and temperature not specified in the publication

742073

0.019

4-cyanobenzyl carbamimidothioate hydrobromide

Homo sapiens

-

in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C

711422

0.016

4-ethylbenzyl carbamimidothioate hydrochloride

Homo sapiens

-

in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C

711422

0.026

4-fluoro-2-(1H-pyrazol-3-yl)phenol

2 entries

0.013

4-fluorobenzyl carbamimidothioate hydrochloride

Homo sapiens

-

in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C

711422

0.4

4-hydroxycarbazole

Homo sapiens

P14902

in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C

712694

1.371

4-iodo-5-phenyl-1H-1,2,3-triazole

Homo sapiens

-

pH 6.5, 37°C, recombinant enzyme

724912

0.0055

4-methoxy-1-naphthylamine

Homo sapiens

P14902

in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C

712694

0.000062

4-methoxy-3'-[(phenylcarbamoyl)amino]-4'-[(5,6,7,8-tetrahydronaphthalen-1-yl)oxy][1,1'-biphenyl]-3-carboxylic acid

Homo sapiens

P14902

pH and temperature not specified in the publication, cellular assay of kynurenine production

764287

-

0.000049

4-methoxy-3'-[[(2-methylphenyl)carbamoyl]amino]-4'-[(5,6,7,8-tetrahydronaphthalen-1-yl)oxy][1,1'-biphenyl]-3-carboxylic acid

Homo sapiens

P14902

pH and temperature not specified in the publication, cellular assay of kynurenine production

764287

-

0.0001

4-methoxy-3'-[[(3-methylphenyl)carbamoyl]amino]-4'-[(5,6,7,8-tetrahydronaphthalen-1-yl)oxy][1,1'-biphenyl]-3-carboxylic acid

Homo sapiens

P14902

pH and temperature not specified in the publication, cellular assay of kynurenine production

764287

-

0.00033

4-methoxy-3'-[[(4-methylphenyl)carbamoyl]amino]-4'-(2-propylphenoxy)[1,1'-biphenyl]-3-carboxylic acid

Homo sapiens

P14902

pH and temperature not specified in the publication, cellular assay of kynurenine production

764287

-

0.0001

4-methoxy-3'-[[(4-methylphenyl)carbamoyl]amino]-4'-[(5,6,7,8-tetrahydronaphthalen-1-yl)oxy][1,1'-biphenyl]-3-carboxylic acid

Homo sapiens

P14902

pH and temperature not specified in the publication, cellular assay of kynurenine production

764287

-

0.00034

4-methoxy-3'-[[(4-methylphenyl)carbamoyl]amino]-4'-[2-(propan-2-yl)phenoxy][1,1'-biphenyl]-3-carboxylic acid

Homo sapiens

P14902

pH and temperature not specified in the publication, cellular assay of kynurenine production

764287

-

0.00005

4-methoxy-3'-[[(4-methylphenyl)carbamoyl]amino]-4'-[2-methyl-3-[(prop-2-yn-1-yl)oxy]phenoxy][1,1'-biphenyl]-3-carboxylic acid

Homo sapiens

P14902

pH and temperature not specified in the publication, cellular assay of kynurenine production

764287

-

0.052

4-methoxybenzyl carbamimidothioate hydrochloride

Homo sapiens

-

in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C

711422

0.03

4-methylbenzyl carbamimidothioate hydrochloride

Homo sapiens

-

in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C

711422

0.533

4-nitro-5-(4-nitrophenyl)-1H-1,2,3-triazole

Homo sapiens

-

pH 6.5, 37°C, recombinant enzyme

724912

0.011

4-nitrobenzyl carbamimidothioate hydrochloride

Homo sapiens

-

in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C

711422

1

4-phenyl-1,3-thiazol-2-amine

Homo sapiens

P14902

in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C

712694

0.024

4-phenyl-1,3-thiazole-2(3H)-thione

Homo sapiens

P14902

pH 6.5, 22°C

764286

-

0.05

4-phenyl-1,3-thiazole-2-thiol

Homo sapiens

P14902

in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C

712694

0.00048 - 0.048

4-phenylimidazole

2 entries

0.1

4-tert-butylbenzyl carbamimidothioate hydrobromide

Homo sapiens

-

IC50 above 0.1 mM, in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C

711422

0.05718

4-[(1Z)-2-[(6-bromo-1H-indazol-4-yl)amino]-N-hydroxyethanimidoyl]phenol

Homo sapiens

P14902

22°C, pH 6.5

765226

-

0.001928

4-[(4,9-dioxo-4,9-dihydro-1H-naphtho[2,3-d][1,2,3]triazol-1-yl)methyl]-N,N-diethylbenzamide

Homo sapiens

P14902

pH 8.0, 37°C

743064

0.002323

4-[(4,9-dioxo-4,9-dihydro-1H-naphtho[2,3-d][1,2,3]triazol-1-yl)methyl]benzoic acid

Homo sapiens

P14902

pH 8.0, 37°C

743064

0.1

4-[(carbamimidoylsulfanyl)methyl]benzoic acid hydrochloride

Homo sapiens

-

IC50 above 0.1 mM, in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C

711422

0.0002

4-[([4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]carbamoyl)amino]benzamide

Homo sapiens

P14902

pH and temperature not specified in the publication

764273

-

0.000199 - 0.000203

4-[([4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]carbamoyl)amino]benzene-1-sulfonamide

2 entries

-

0.0000836

4-[([4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]carbamoyl)amino]benzoic acid

Homo sapiens

P14902

pH and temperature not specified in the publication

764273

-

0.000061

4-[2-(4-bromophenyl)hydrazinesulfonyl]benzoic acid

Homo sapiens

P14902

pH and temperature not specified in the publication

742073

0.038

4-[2-(methylsulfanyl)phenyl]-1H-imidazole

Homo sapiens

P14902

pH and temperature not specified in the publication

711910

0.073

4-[3-(methylsulfanyl)phenyl]-1H-imidazole

Homo sapiens

P14902

pH and temperature not specified in the publication

711910

0.00564

4-[[(6-bromo-1H-indazol-4-yl)amino]methyl]phenol

Homo sapiens

P14902

22°C, pH 6.5

765226

-

0.148

5-(2-bromophenyl)-1H-1,2,3-triazole

Homo sapiens

-

pH 6.5, 37°C, recombinant enzyme

724912

0.086

5-(2-chlorophenyl)-1H-1,2,3-triazole

Homo sapiens

-

pH 6.5, 37°C, recombinant enzyme

724912

1.028

5-(2-methoxyphenyl)-1H-1,2,3-triazole

Homo sapiens

-

pH 6.5, 37°C, recombinant enzyme

724912

1.256

5-(4-bromophenyl)-1H-1,2,3-triazole

Homo sapiens

-

pH 6.5, 37°C, recombinant enzyme

724912

0.817

5-(4-chlorophenyl)-1H-1,2,3-triazole

Homo sapiens

-

pH 6.5, 37°C, recombinant enzyme

724912

0.000256

5-(4-chlorophenyl)-3-[(2-methylpropyl)sulfanyl][1,3]thiazolo-[2,3-c][1,2,4]triazole

Homo sapiens

P14902

pH and temperature not specified in the publication

765223

-

0.58

5-(4-fluorophenyl)-1H-1,2,3-triazole

Homo sapiens

-

pH 6.5, 37°C, recombinant enzyme

724912

6

5-(4-methoxyphenyl)-1H-1,2,3-triazole

Homo sapiens

-

pH 6.5, 37°C, recombinant enzyme

724912

0.04

5-(ethylamino)quinolin-8-ol

Homo sapiens

P14902

in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C

712694

0.015

5-(isopropylamino)quinolin-8-ol

Homo sapiens

P14902

in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C

712694

0.003

5-amino-8-hydroxyquinoline

Homo sapiens

P14902

in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C

712694

0.05

5-chloro-1,3-benzothiazole-2(3H)-thione

Homo sapiens

P14902

in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C

712694

0.001

5-hydroxy-1,4-naphthoquinone

Homo sapiens

P14902

-

699424

0.06 - 0.143

5-phenyl-1H-1,2,3-triazole

2 entries

0.0088

5-[(2E)-2-[(4-bromophenyl)methylidene]hydrazinyl]-1-(naphthalen-1-yl)tetrazolidine

Homo sapiens

P14902

pH 6.5, 37°C

764463

-

0.00945

6-bromo-1H-indazol-4-amine

Homo sapiens

P14902

22°C, pH 6.5

765226

-

0.00109

6-bromo-N-(cyclohexylmethyl)-1H-indazol-4-amine

Homo sapiens

P14902

22°C, pH 6.5

765226

-

0.03207

6-bromo-N-[(1,4-dioxaspiro[4.5]decan-6-yl)methyl]-1H-indazol-4-amine

Homo sapiens

P14902

22°C, pH 6.5

765226

-

0.203

6-bromo-N-[(1R,2R)-2-hydroxycyclohexyl]-1H-indazole-4-carboxamide

Homo sapiens

P14902

22°C, pH 6.5

765226

-

0.05155

6-bromo-N-[(pyridin-2-yl)methyl]-1H-indazol-4-amine

Homo sapiens

P14902

22°C, pH 6.5

765226

-

0.1049

6-bromo-N-[(pyrrolidin-3-yl)methyl]-1H-indazol-4-amine

Homo sapiens

P14902

22°C, pH 6.5

765226

-

0.0555

6-bromo-N-[[(1S,2R)-2-chlorocyclohexyl]methyl]-1H-indazol-4-amine

Homo sapiens

P14902

22°C, pH 6.5

765226

-

0.00029

6-bromo-N-[[(1S,2S)-2-chlorocyclohexyl]methyl]-1H-indazol-4-amine

Homo sapiens

P14902

22°C, pH 6.5

765226

-

0.01736

6-bromo-N-[[(2R)-piperidin-2-yl]methyl]-1H-indazol-4-amine

Homo sapiens

P14902

22°C, pH 6.5

765226

-

0.05645

6-bromo-N-[[(2R)-pyrrolidin-2-yl]methyl]-1H-indazol-4-amine

Homo sapiens

P14902

22°C, pH 6.5

765226

-

0.01375

6-bromo-N-[[(2S)-piperidin-2-yl]methyl]-1H-indazol-4-amine

Homo sapiens

P14902

22°C, pH 6.5

765226

-

0.00474

6-bromo-N-[[(2S)-pyrrolidin-2-yl]methyl]-1H-indazol-4-amine

Homo sapiens

P14902

22°C, pH 6.5

765226

-

0.00019

6-hydroxy-2,2-dimethyl-2H-benzo[g]chromene-5,10-dione

Homo sapiens

P14902

-

699424

0.00019

6-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione

Homo sapiens

P14902

pH and temperature not specified in the publication

711910

0.00213

6-methoxy-2,2-dimethyl-2H-benzo[g]chromene-5,10-dione

Homo sapiens

P14902

-

699424

0.0031

7-hydroxy-1,6,6-trimethyl-6,7-dihydrophenanthro[1,2-b]furan-10,11-dione

Homo sapiens

P14902

37°C, pH 6.5

765415

-

0.00552

7-hydroxy-2,2-dimethyl-2H-benzo[g]chromene-5,10-dione

Homo sapiens

P14902

-

699424

0.00302

7-methoxy-2,2-dimethyl-2H-benzo[g]chromene-5,10-dione

Homo sapiens

P14902

-

699424

0.01309

8-fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indolo[2,1-b]quinazoline-6,12-dione

Homo sapiens

P14902

pH and temperature not specified in the publication

764295

-

0.00078

8-fluoro-2-[(1H-1,2,3-triazol-1-yl)methyl]indolo[2,1-b]quinazoline-6,12-dione

Homo sapiens

P14902

pH and temperature not specified in the publication

764295

-

0.00046

8-fluoro-6,12-dioxo-6,12-dihydroindolo[2,1-b]quinazoline-2-carbaldehyde

Homo sapiens

P14902

pH and temperature not specified in the publication

764295

-

0.000534

8-fluorotryptanthrin

Homo sapiens

P14902

pH and temperature not specified in the publication

764295

-

0.002 - 0.00205

8-hydroxy-2,2-dimethyl-2H-benzo[g]chromene-5,10-dione

2 entries

0.000933

8-methoxy-2,2-dimethyl-2H-benzo[g]chromene-5,10-dione

Homo sapiens

P14902

-

699424

0.2

9-fluorenone

Homo sapiens

P14902

IC50 above 0.2 mM, in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C

712694

0.00283

9-hydroxy-1,6,6-trimethyl-6,7,8,9-tetrahydrophenanthro[1,2-b]furan-10,11-dione

Homo sapiens

P14902

37°C, pH 6.5

765415

-

0.000121

9-hydroxy-2,2-dimethyl-2H-benzo[g]chromene-5,10-dione

Homo sapiens

P14902

alpha-caryopterone

699424

1

9-hydroxyfluorene

Homo sapiens

P14902

IC50 above 1.0 mM, in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C

712694

0.00292

9-methoxy-2,2-dimethyl-2H-benzo[g]chromene-5,10-dione

2 entries

0.000017

antisense oligonucleotide A06007H

Homo sapiens

P14902

pH and temperature not specified in the publication, cellular assay of kynurenine production

764396

-

0.000036

antisense oligonucleotide A06008H

Homo sapiens

P14902

pH and temperature not specified in the publication, cellular assay of kynurenine production

764396

-

0.000011

antisense oligonucleotide A06030H

Homo sapiens

P14902

pH and temperature not specified in the publication, cellular assay of kynurenine production

764396

-

0.000049

antisense oligonucleotide A06043H

Homo sapiens

P14902

pH and temperature not specified in the publication, cellular assay of kynurenine production

764396

-

0.000205

antisense oligonucleotide A06044H

Homo sapiens

P14902

pH and temperature not specified in the publication, cellular assay of kynurenine production

764396

-

0.000078

antisense oligonucleotide A06045H

Homo sapiens

P14902

pH and temperature not specified in the publication, cellular assay of kynurenine production

764396

-

0.000368

antisense oligonucleotide A07006H

Homo sapiens

P14902

pH and temperature not specified in the publication, cellular assay of kynurenine production

764396

-

0.000842

antisense oligonucleotide A07058H

Homo sapiens

P14902

pH and temperature not specified in the publication, cellular assay of kynurenine production

764396

-

1

benzophenone

Homo sapiens

P14902

in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C

712694

0.061

benzyl carbamimidothioate hydrochloride

Homo sapiens

-

in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C

711422

0.0093

Berberine

Homo sapiens

-

pH and temperature not specified in the publication

712230

0.07

Dichlorophene

Homo sapiens

P14902

in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C

712694

0.00001 - 0.00009

epacadostat

3 entries

-

0.00019

ethyl (2E)-3-(8-fluoro-6,12-dioxo-6,12-dihydroindolo[2,1-b]quinazolin-2-yl)prop-2-enoate

Homo sapiens

P14902

pH and temperature not specified in the publication

764295

-

0.00747

ethyl 1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl (2E)-but-2-enedioate

Homo sapiens

P14902

37°C, pH 6.5

765415

-

2

ethyl 1-(4-chlorophenyl)-1H-1,2,3-triazole-4-carboxylate

Homo sapiens

-

pH 6.5, 37°C, recombinant enzyme

724912

0.0077

galanal

Homo sapiens

P14902

pH 6.5, 37°C, recombinant His-tagged enzyme

743654

0.00088

gamma-glutamyl-S-(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)cysteinylglycine

Homo sapiens

P14902

pH and temperature not specified in the publication

711910

0.000097

INCB024360

Homo sapiens

P14902

pH and temperature not specified in the publication

764294

-

0.0077

kushenol E

Homo sapiens

P14902

pH 6.5, 37°C

765149

0.0254

kushenol F

Homo sapiens

P14902

pH 6.5, 37°C

765149

-

0.00064

menadione

Homo sapiens

P14902

in PBS buffer (pH 7.4), at 37°C

711229

0.00143

methyl 1-[(8-fluoro-6,12-dioxo-6,12-dihydroindolo[2,1-b]quinazolin-2-yl)methyl]piperidine-3-carboxylate

Homo sapiens

P14902

pH and temperature not specified in the publication

764295

-

0.0012

methyl 1-[(8-fluoro-6,12-dioxo-6,12-dihydroindolo[2,1-b]quinazolin-2-yl)methyl]piperidine-4-carboxylate

Homo sapiens

P14902

pH and temperature not specified in the publication

764295

-

0.00046

methyl 1-[(8-fluoro-6,12-dioxo-6,12-dihydroindolo[2,1-b]quinazolin-2-yl)methyl]prolinate

Homo sapiens

P14902

pH and temperature not specified in the publication

764295

-

0.000247

methyl 2-methyl-5,10-dioxo-5,10-dihydro-2H-benzo[g]chromene-2-carboxylate

Homo sapiens

P14902

-

699424

0.000121

methyl 3-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]propanoate

Homo sapiens

P14902

pH and temperature not specified in the publication

742073

0.00366

methyl 4-([[(1S,2R)-2-hydroxycyclohexyl]methyl]amino)-1H-indazole-6-carboxylate

Homo sapiens

P14902

22°C, pH 6.5

765226

-

0.1

methyl 4-[(carbamimidoylsulfanyl)methyl]benzenesulfinate hydrobromide

Homo sapiens

-

IC50 above 0.1 mM, in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C

711422

0.1

methyl N-(4-chlorophenyl)carbamimidothioate hydroiodide

Homo sapiens

-

IC50 above 0.1 mM, in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C

711422

0.1

methyl N-[2-(4-chlorophenyl)ethyl]carbamimidothioate hydroiodide

Homo sapiens

-

IC50 above 0.1 mM, in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C

711422

0.0216 - 0.0826

methyl thiohydantoin-Trp

2 entries

0.000059

N'-(3-methylphenyl)-4-[[5-(trifluoromethyl)pyridin-2-yl]oxy]benzene-1-sulfonohydrazide

Homo sapiens

P14902

pH and temperature not specified in the publication

742073

0.000176

N'-(4-bromophenyl)-4-cyanobenzene-1-sulfonohydrazide

Homo sapiens

P14902

pH and temperature not specified in the publication

742073

0.001431

N'-(4-bromophenyl)-4-methoxybenzene-1-sulfonohydrazide

Homo sapiens

P14902

pH and temperature not specified in the publication

742073

0.000172

N'-(4-bromophenyl)benzenesulfonohydrazide

Homo sapiens

P14902

pH and temperature not specified in the publication

742073

0.000405

N'-[4-[bis(2-methylpropyl)amino]-2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-3-yl]-N-methyl-N-(4-methylphenyl)urea

Homo sapiens

P14902

pH and temperature not specified in the publication, cellular assay of kynurenine production

764292

-

1

N,N-dimethyl-1-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]methanamine

Homo sapiens

P14902

IC50 above 1.0 mM, in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C

712694

0.003 - 0.25

N-(1,3-benzodioxol-5-yl)-2-([5-(4-methylphenyl)[1,3]thiazolo[2,3-c][1,2,4]triazol-3-yl]sulfanyl)acetamide

2 entries

0.0000093 - 0.0000132

N-(3-((1H-benzo[d]imidazol-1-yl)methyl)benzyl)-1H-indole-2-carboxamide

2 entries

-

0.00000546 - 0.0000127

N-(3-((1H-benzo[d]imidazol-1-yl)methyl)benzyl)-4-bromo-1H-pyrrole-2-carboxamide

2 entries

-

0.0000323 - 0.000112

N-(3-((1H-benzo[d]imidazol-1-yl)methyl)benzyl)-4-cyanobenzamide

2 entries

-

0.000056

N-(3-bromo-4-fluorophenyl)-N'-hydroxy-4-[[2-(sulfamoylamino)ethyl]amino]-1,2,5-oxadiazole-3-carboximidamide

Homo sapiens

P14902

22°C, pH 6.5

765226

-

0.000076

N-(4'-[bis(2-methylpropyl)amino]-3'-[[(4-methylphenyl)carbamoyl]amino][1,1'-biphenyl]-2-yl)-1,1,1-trifluoromethanesulfonamide

Homo sapiens

P14902

pH and temperature not specified in the publication, cellular assay of kynurenine production

764292

-

0.0029

N-(4-bromophenyl)-N'-[4-(2-tert-butylphenoxy)[1,1'-biphenyl]-3-yl]urea

Homo sapiens

P14902

pH and temperature not specified in the publication, cellular assay of kynurenine production

764287

-

0.044

N-(4-hydroxy-1-naphthyl)ethane-1,2-diaminium chloride

Homo sapiens

P14902

in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C

712694

0.005

N-(4-hydroxy-1-naphthyl)propane-1,3-diaminium chloride

Homo sapiens

P14902

in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C

712694

0.2

N-(4-hydroxynaphthalen-1-yl)pyrrolidine-2-carboxamide

Homo sapiens

P14902

in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C

712694

0.001605

N-(4-[2-[4-(trifluoromethyl)phenyl]hydrazinesulfonyl]phenyl)acetamide

Homo sapiens

P14902

pH and temperature not specified in the publication

742073

0.00161

N-(4-[[(6-bromo-1H-indazol-4-yl)amino]methyl]cyclohexylidene)hydroxylamine

Homo sapiens

P14902

22°C, pH 6.5

765226

-

0.25

N-carbamoyl-2-([5-(4-methylphenyl)[1,3]thiazolo[2,3-c][1,2,4]triazol-3-yl]sulfanyl)acetamide

2 entries

0.4

N-phenyl-p-phenylenediamine

Homo sapiens

P14902

in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C

712694

0.0238

N-[(1,3-benzothiazol-2-yl)sulfanyl]-2-nitrobenzene-1-sulfonamide

Homo sapiens

P14902

pH 6.5, 37°C

764463

-

0.1127

N-[(azetidin-3-yl)methyl]-6-bromo-1H-indazol-4-amine

Homo sapiens

P14902

22°C, pH 6.5

765226

-

0.00077

N-[2-[4,7-dioxo-5-(pyridin-3-yl)-4,7-dihydro-1H-indol-3-yl]ethyl]-2,2-dimethylpropanamide

Homo sapiens

P14902

pH and temperature not specified in the publication

764294

-

0.00136

N-[2-[4,7-dioxo-5-(pyridin-3-yl)-4,7-dihydro-1H-indol-3-yl]ethyl]acetamide

Homo sapiens

P14902

pH and temperature not specified in the publication

764294

-

0.00208

N-[2-[4,7-dioxo-5-(pyridin-3-yl)-4,7-dihydro-1H-indol-3-yl]ethyl]benzamide

Homo sapiens

P14902

pH and temperature not specified in the publication

764294

-

0.00351

N-[2-[4,7-dioxo-5-(pyridin-3-yl)-4,7-dihydro-1H-indol-3-yl]ethyl]benzenesulfonamide

Homo sapiens

P14902

pH and temperature not specified in the publication

764294

-

0.000071

N-[4-(2-phenylhydrazinesulfonyl)phenyl]acetamide

Homo sapiens

P14902

pH and temperature not specified in the publication

742073

0.001

N-[4-(2-tert-butylphenoxy)[1,1'-biphenyl]-3-yl]-N'-(2-methylphenyl)urea

Homo sapiens

P14902

pH and temperature not specified in the publication, cellular assay of kynurenine production

764287

-

0.00057

N-[4-(2-tert-butylphenoxy)[1,1'-biphenyl]-3-yl]-N'-(3-methylphenyl)urea

Homo sapiens

P14902

pH and temperature not specified in the publication, cellular assay of kynurenine production

764287

-

0.0018

N-[4-(2-tert-butylphenoxy)[1,1'-biphenyl]-3-yl]-N'-(4-methoxyphenyl)urea

Homo sapiens

P14902

pH and temperature not specified in the publication, cellular assay of kynurenine production

764287

-

0.00079

N-[4-(2-tert-butylphenoxy)[1,1'-biphenyl]-3-yl]-N'-(4-methylphenyl)urea

Homo sapiens

P14902

pH and temperature not specified in the publication, cellular assay of kynurenine production

764287

-

0.0015

N-[4-(2-tert-butylphenoxy)[1,1'-biphenyl]-3-yl]-N'-phenylurea

Homo sapiens

P14902

pH and temperature not specified in the publication, cellular assay of kynurenine production

764287

-

0.0026

N-[4-(2-tert-butylphenoxy)[1,1'-biphenyl]-3-yl]-N'-[4-(difluoromethoxy)phenyl]urea

Homo sapiens

P14902

pH and temperature not specified in the publication, cellular assay of kynurenine production

764287

-

0.004

N-[4-(2-tert-butylphenoxy)[1,1'-biphenyl]-3-yl]-N'-[4-(trifluoromethoxy)phenyl]urea

Homo sapiens

P14902

pH and temperature not specified in the publication, cellular assay of kynurenine production

764287

-

0.000608

N-[4-[2-(2,4-difluorophenyl)hydrazinesulfonyl]phenyl]acetamide

Homo sapiens

P14902

pH and temperature not specified in the publication

742073

0.000247

N-[4-[2-(3,4-dichlorophenyl)hydrazinesulfonyl]phenyl]acetamide

Homo sapiens

P14902

pH and temperature not specified in the publication

742073

0.000352

N-[4-[2-(3,5-dichlorophenyl)hydrazinesulfonyl]phenyl]acetamide

Homo sapiens

P14902

pH and temperature not specified in the publication

742073

0.001746

N-[4-[2-(3,5-difluorophenyl)hydrazinesulfonyl]phenyl]acetamide

Homo sapiens

P14902

pH and temperature not specified in the publication

742073

0.000128

N-[4-[2-(3-bromo-4-fluorophenyl)hydrazinesulfonyl]phenyl]acetamide

Homo sapiens

P14902

pH and temperature not specified in the publication

742073

0.000255

N-[4-[2-(3-bromophenyl)hydrazinesulfonyl]phenyl]acetamide

Homo sapiens

P14902

pH and temperature not specified in the publication

742073

0.00011

N-[4-[2-(3-chloro-4-fluorophenyl)hydrazinesulfonyl]phenyl]acetamide

Homo sapiens

P14902

pH and temperature not specified in the publication

742073

0.000122

N-[4-[2-(3-fluorophenyl)hydrazinesulfonyl]phenyl]acetamide

Homo sapiens

P14902

pH and temperature not specified in the publication

742073

0.00008

N-[4-[2-(3-methylphenyl)hydrazinesulfonyl]benzoyl]glycine

Homo sapiens

P14902

pH and temperature not specified in the publication

742073

0.000049

N-[4-[2-(3-methylphenyl)hydrazinesulfonyl]phenyl]acetamide

Homo sapiens

P14902

pH and temperature not specified in the publication

742073

0.000205

N-[4-[2-(4-bromo-3-fluorophenyl)hydrazinesulfonyl]phenyl]acetamide

Homo sapiens

P14902

pH and temperature not specified in the publication

742073

0.000058

N-[4-[2-(4-bromo-3-methylphenyl)hydrazinesulfonyl]phenyl]acetamide

Homo sapiens

P14902

pH and temperature not specified in the publication

742073

0.00023

N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]-N'-(3-chlorophenyl)urea

Homo sapiens

P14902

pH and temperature not specified in the publication

764273

-

0.000146

N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]-N'-(3-cyanophenyl)urea

Homo sapiens

P14902

pH and temperature not specified in the publication

764273

-

0.00048

N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]-N'-(3-fluorophenyl)urea

Homo sapiens

P14902

pH and temperature not specified in the publication

764273

-

0.0000461

N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]-N'-(3-methoxyphenyl)urea

Homo sapiens

P14902

pH and temperature not specified in the publication

764273

-

0.0000536

N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]-N'-(3-methylphenyl)urea

Homo sapiens

P14902

pH and temperature not specified in the publication

764273

-

0.000184

N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]-N'-(4-chlorophenyl)urea

Homo sapiens

P14902

pH and temperature not specified in the publication

764273

-

0.0000607

N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]-N'-(4-methoxyphenyl)urea

Homo sapiens

P14902

pH and temperature not specified in the publication

764273

-

0.0000703

N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]-N'-(4-methylphenyl)urea

Homo sapiens

P14902

pH and temperature not specified in the publication

764273

-

0.000157

N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]-N'-butylurea

Homo sapiens

P14902

pH and temperature not specified in the publication

764273

-

0.000161

N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]-N'-cyclohexylurea

Homo sapiens

P14902

pH and temperature not specified in the publication

764273

-

0.0000726

N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]-N'-[3-(1H-tetrazol-5-yl)phenyl]urea

Homo sapiens

P14902

pH and temperature not specified in the publication

764273

-

0.000207

N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]-N'-[4-(1H-tetrazol-5-yl)phenyl]urea

Homo sapiens

P14902

pH and temperature not specified in the publication

764273

-

0.00013

N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]acetamide

Homo sapiens

P14902

pH and temperature not specified in the publication

742073

0.000132

N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]butanamide

Homo sapiens

P14902

pH and temperature not specified in the publication

742073

0.000194

N-[4-[2-(4-chloro-3-fluorophenyl)hydrazinesulfonyl]phenyl]acetamide

Homo sapiens

P14902

pH and temperature not specified in the publication

742073

0.000155

N-[4-[2-(4-chlorophenyl)hydrazinesulfonyl]phenyl]acetamide

Homo sapiens

P14902

pH and temperature not specified in the publication

742073

0.005667

N-[4-[2-(4-cyanophenyl)hydrazinesulfonyl]phenyl]acetamide

Homo sapiens

P14902

pH and temperature not specified in the publication

742073

0.000079

N-[4-[2-(4-fluorophenyl)hydrazinesulfonyl]phenyl]acetamide

Homo sapiens

P14902

pH and temperature not specified in the publication

742073

0.000254

N-[4-[2-(4-methoxyphenyl)hydrazinesulfonyl]phenyl]acetamide

Homo sapiens

P14902

pH and temperature not specified in the publication

742073

0.000051

N-[4-[2-(4-methylphenyl)hydrazinesulfonyl]phenyl]acetamide

Homo sapiens

P14902

pH and temperature not specified in the publication

742073

0.002475

N-[4-[2-(4-sulfamoylphenyl)hydrazinesulfonyl]phenyl]acetamide

Homo sapiens

P14902

pH and temperature not specified in the publication

742073

0.000005 - 0.000097

N-[4-[bis(2-methylpropyl)amino]-2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-3-yl]-2-(4-methylphenyl)acetamide

2 entries

-

0.000004

N-[4-[bis(2-methylpropyl)amino]-2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-3-yl]-N'-(4-methylphenyl)urea

Homo sapiens

P14902

pH and temperature not specified in the publication, cellular assay of kynurenine production

764292

-

0.0007

N-[[(1S,2R)-2-aminocyclohexyl]methyl]-6-bromo-1H-indazol-4-amine

Homo sapiens

P14902

22°C, pH 6.5

765226

-

0.00142

N-[[(1S,2S)-2-aminocyclohexyl]methyl]-6-bromo-1H-indazol-4-amine

Homo sapiens

P14902

22°C, pH 6.5

765226

-

0.00008

N-[[3-(4-bromophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methyl]-4-oxobutanamide

Homo sapiens

P14902

pH and temperature not specified in the publication

764291

-

0.00069

N-[[3-(4-bromophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methyl]-N2-methyl-N2-(phenylacetyl)glycinamide

Homo sapiens

P14902

pH and temperature not specified in the publication

764291

-

0.00073

N-[[3-(4-bromophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methyl]-N2-methyl-N2-[(2-nitrophenyl)acetyl]glycinamide

Homo sapiens

P14902

pH and temperature not specified in the publication

764291

-

0.00063

N-[[3-(4-bromophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methyl]-N2-methyl-N2-[(3-nitrophenyl)acetyl]glycinamide

Homo sapiens

P14902

pH and temperature not specified in the publication

764291

-

0.00081

N-[[3-(4-bromophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methyl]-N2-methyl-N2-[(4-nitrophenyl)acetyl]glycinamide

Homo sapiens

P14902

pH and temperature not specified in the publication

764291

-

0.00045

N-[[3-(4-bromophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methyl]-N2-[(3-hydroxyphenyl)acetyl]-N2-methylglycinamide

Homo sapiens

P14902

pH and temperature not specified in the publication

764291

-

0.0015

naphthalene-1,4-diol

Homo sapiens

P14902

in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C

712694

0.00099

naphthalene-1,4-dione

Homo sapiens

P14902

pH and temperature not specified in the publication

711910

0.0235

noranhydroicaritin

Homo sapiens

P14902

pH 6.5, 37°C

765149

0.0017

phenylmethanethiol

Homo sapiens

-

in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C

711422

0.05

primaquine

Homo sapiens

P14902

in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C

712694

0.001202

propan-2-yl 4-[([4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]carbamoyl)amino]benzoate

Homo sapiens

P14902

pH and temperature not specified in the publication

764273

-

0.006 - 0.0095

prostaglandin (19R)-hydroxy-PGE2

2 entries

0.0067 - 0.03

prostaglandin 13,14-dihydro-15-oxo-PGE2

2 entries

0.0068 - 0.009

prostaglandin 15-oxo-PGE2

2 entries

0.0076 - 0.0231

prostaglandin 15-oxo-PGF2alpha

2 entries

0.0074 - 0.0112

prostaglandin 20-hydroxy PGE2

2 entries

0.0046 - 0.0071

prostaglandin DELTA12-PGJ2

2 entries

0.0049 - 0.0078

prostaglandin PGA2

2 entries

0.0041 - 0.0074

prostaglandin PGD2

2 entries

0.0047 - 0.0057

prostaglandin PGD2 ethanolamide

2 entries

0.01 - 0.0221

prostaglandin PGE2

2 entries

0.0046 - 0.0063

prostaglandin PGE2 ethanolamide

2 entries

0.0071 - 0.0074

prostaglandin PGF2beta

2 entries

0.0092 - 0.0112

prostaglandin PGG2

2 entries

0.0072 - 0.0096

prostaglandin PGH2

2 entries

0.0042 - 0.0067

prostaglandin PGJ2

2 entries

0.75

quinolin-8-ol

Homo sapiens

P14902

in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C

712694

0.1

sodium 4-chlorobenzenesulfinate

Homo sapiens

-

IC50 above 0.1 mM, in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C

711422

0.0193

sophoraflavanone B

Homo sapiens

P14902

pH 6.5, 37°C

765149

0.00902

tert-butyl 3-[[(6-bromo-1H-indazol-4-yl)amino]methyl]pyrrolidine-1-carboxylate

Homo sapiens

P14902

22°C, pH 6.5

765226

-

0.00294

tert-butyl [2-(4,7-dioxo-5-phenyl-4,7-dihydro-1H-indol-3-yl)ethyl]carbamate

Homo sapiens

P14902

pH and temperature not specified in the publication

764294

-

0.0019

tert-butyl [2-[4,7-dioxo-5-(pyridin-3-yl)-4,7-dihydro-1H-indol-3-yl]ethyl]carbamate

Homo sapiens

P14902

pH and temperature not specified in the publication

764294

-

0.00209

tert-butyl [2-[5-(2-fluorophenyl)-4,7-dioxo-4,7-dihydro-1H-indol-3-yl]ethyl]carbamate

Homo sapiens

P14902

pH and temperature not specified in the publication

764294

-

0.00238

tert-butyl [2-[5-(2-methoxyphenyl)-4,7-dioxo-4,7-dihydro-1H-indol-3-yl]ethyl]carbamate

Homo sapiens

P14902

pH and temperature not specified in the publication

764294

-

0.001

vitamin K3

Homo sapiens

P14902

-

695525

0.000125

[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenoxy]acetic acid

Homo sapiens

P14902

pH and temperature not specified in the publication

742073

additional information

additional information

2 entries

-

0.0044

15-deoxy-DELTA12,14-prostaglandin

Homo sapiens

-

pH not specified in the publication, 37°C, inhibition of human monocytes

743716

0.013

15-deoxy-DELTA12,14-prostaglandin

Homo sapiens

-

pH not specified in the publication, 37°C, inhibition of human THP-1 cells

743716

0.25

2-([5-(3-methoxyphenyl)[1,3]thiazolo[2,3-c][1,2,4]triazol-3-yl]sulfanyl)-N-(5-methyl-1,3-thiazol-2-yl)acetamide

Homo sapiens

F5H5G0, P14902

above, pH 7.0, 22°C, IDO1

724429

0.25

2-([5-(3-methoxyphenyl)[1,3]thiazolo[2,3-c][1,2,4]triazol-3-yl]sulfanyl)-N-(5-methyl-1,3-thiazol-2-yl)acetamide

Homo sapiens

F5H5G0, P14902

above, pH 7.0, 22°C, IDO2

724429

0.68

3-(1H-1,2,3-triazol-5-yl)pyridine

Homo sapiens

P14902

in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C

712694

0.708

3-(1H-1,2,3-triazol-5-yl)pyridine

Homo sapiens

-

pH 6.5, 37°C, recombinant enzyme

724912

0.825

3-(1H-imidazol-4-yl)benzaldehyde

Homo sapiens

P14902

-

699438

0.825

3-(1H-imidazol-4-yl)benzaldehyde

Homo sapiens

P14902

pH and temperature not specified in the publication

711910

0.179

4-(2-fluorophenyl)-1H-imidazole

Homo sapiens

P14902

-

699438

0.179

4-(2-fluorophenyl)-1H-imidazole

Homo sapiens

P14902

pH and temperature not specified in the publication

711910

0.000055

4-(benzylamino)-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione

Homo sapiens

P14902

pH and temperature not specified in the publication

711910

0.00025

4-(benzylamino)-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione

Homo sapiens

P14902

pH and temperature not specified in the publication

711910

0.422

4-(thiophen-2-yl)-1H-imidazole

Homo sapiens

P14902

-

699438

0.422

4-(thiophen-2-yl)-1H-imidazole

Homo sapiens

P14902

pH and temperature not specified in the publication

711910

0.026

4-fluoro-2-(1H-pyrazol-3-yl)phenol

Homo sapiens

P14902

-

699438

0.026

4-fluoro-2-(1H-pyrazol-3-yl)phenol

Homo sapiens

P14902

pH and temperature not specified in the publication

711910

0.00048

4-phenylimidazole

Homo sapiens

P14902, Q6ZQW0

pH and temperature not specified in the publication

765516

0.048

4-phenylimidazole

Homo sapiens

P14902

-

699438

0.000199

4-[([4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]carbamoyl)amino]benzene-1-sulfonamide

Homo sapiens

P14902

pH and temperature not specified in the publication

764273

-

0.000203

4-[([4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]carbamoyl)amino]benzene-1-sulfonamide

Homo sapiens

P14902

pH and temperature not specified in the publication

764273

-

0.06

5-phenyl-1H-1,2,3-triazole

Homo sapiens

P14902

in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C

712694

0.143

5-phenyl-1H-1,2,3-triazole

Homo sapiens

-

pH 6.5, 37°C, recombinant enzyme

724912

0.002

8-hydroxy-2,2-dimethyl-2H-benzo[g]chromene-5,10-dione

Homo sapiens

P14902

pH and temperature not specified in the publication

711910

0.00205

8-hydroxy-2,2-dimethyl-2H-benzo[g]chromene-5,10-dione

Homo sapiens

P14902

-

699424

0.00292

9-methoxy-2,2-dimethyl-2H-benzo[g]chromene-5,10-dione

Homo sapiens

P14902

-

699424

0.00292

9-methoxy-2,2-dimethyl-2H-benzo[g]chromene-5,10-dione

Homo sapiens

P14902

pH and temperature not specified in the publication

711910

0.00001

epacadostat

Homo sapiens

P14902

pH and temperature not specified in the publication

764291

-

0.000086

epacadostat

Homo sapiens

P14902

pH 6.5, 37°C

765415

-

0.00009

epacadostat

Homo sapiens

P14902

pH and temperature not specified in the publication

764295

-

0.0216

methyl thiohydantoin-Trp

Homo sapiens

F5H5G0, P14902

pH 7.0, 22°C, IDO1

724429

0.0826

methyl thiohydantoin-Trp

Homo sapiens

F5H5G0, P14902

pH 7.0, 22°C, IDO2

724429

0.003

N-(1,3-benzodioxol-5-yl)-2-([5-(4-methylphenyl)[1,3]thiazolo[2,3-c][1,2,4]triazol-3-yl]sulfanyl)acetamide

Homo sapiens

F5H5G0, P14902

pH 7.0, 22°C, IDO1

724429

0.25

N-(1,3-benzodioxol-5-yl)-2-([5-(4-methylphenyl)[1,3]thiazolo[2,3-c][1,2,4]triazol-3-yl]sulfanyl)acetamide

Homo sapiens

F5H5G0, P14902

above, pH 7.0, 22°C, IDO2

724429

0.0000093

N-(3-((1H-benzo[d]imidazol-1-yl)methyl)benzyl)-1H-indole-2-carboxamide

Mus musculus

P28776

pH and temperature not specified in the publication, in cell line P1.IDO1

765224

-

0.0000132

N-(3-((1H-benzo[d]imidazol-1-yl)methyl)benzyl)-1H-indole-2-carboxamide

Mus musculus

P28776

pH and temperature not specified in the publication, in cell line P1.TDO

765224

-

0.00000546

N-(3-((1H-benzo[d]imidazol-1-yl)methyl)benzyl)-4-bromo-1H-pyrrole-2-carboxamide

Mus musculus

P28776

pH and temperature not specified in the publication, in cell line P1.TDO

765224

-

0.0000127

N-(3-((1H-benzo[d]imidazol-1-yl)methyl)benzyl)-4-bromo-1H-pyrrole-2-carboxamide

Mus musculus

P28776

pH and temperature not specified in the publication, in cell line P1.IDO1

765224

-

0.0000323

N-(3-((1H-benzo[d]imidazol-1-yl)methyl)benzyl)-4-cyanobenzamide

Mus musculus

P28776

pH and temperature not specified in the publication, in cell line P1.TDO

765224

-

0.000112

N-(3-((1H-benzo[d]imidazol-1-yl)methyl)benzyl)-4-cyanobenzamide

Mus musculus

P28776

pH and temperature not specified in the publication, in cell line P1.IDO1

765224

-

0.25

N-carbamoyl-2-([5-(4-methylphenyl)[1,3]thiazolo[2,3-c][1,2,4]triazol-3-yl]sulfanyl)acetamide

Homo sapiens

F5H5G0, P14902

above, pH 7.0, 22°C, IDO1

724429

0.25

N-carbamoyl-2-([5-(4-methylphenyl)[1,3]thiazolo[2,3-c][1,2,4]triazol-3-yl]sulfanyl)acetamide

Homo sapiens

F5H5G0, P14902

above, pH 7.0, 22°C, IDO2

724429

0.000005

N-[4-[bis(2-methylpropyl)amino]-2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-3-yl]-2-(4-methylphenyl)acetamide

Homo sapiens

P14902

pH and temperature not specified in the publication, cellular assay of kynurenine production

764292

-

0.000097

N-[4-[bis(2-methylpropyl)amino]-2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-3-yl]-2-(4-methylphenyl)acetamide

Homo sapiens

P14902

pH and temperature not specified in the publication, cellular assay of kynurenine production

764292

-

0.006

prostaglandin (19R)-hydroxy-PGE2

Homo sapiens

-

pH not specified in the publication, 37°C, inhibition of human THP-1 cells

743716

0.0095

prostaglandin (19R)-hydroxy-PGE2

Homo sapiens

-

pH not specified in the publication, 37°C, inhibition of human monocytes

743716

0.0067

prostaglandin 13,14-dihydro-15-oxo-PGE2

Homo sapiens

-

pH not specified in the publication, 37°C, inhibition of human monocytes

743716

0.03

prostaglandin 13,14-dihydro-15-oxo-PGE2

Homo sapiens

-

pH not specified in the publication, 37°C, inhibition of human THP-1 cells

743716

0.0068

prostaglandin 15-oxo-PGE2

Homo sapiens

-

pH not specified in the publication, 37°C, inhibition of human monocytes

743716

0.009

prostaglandin 15-oxo-PGE2

Homo sapiens

-

pH not specified in the publication, 37°C, inhibition of human THP-1 cells

743716

0.0076

prostaglandin 15-oxo-PGF2alpha

Homo sapiens

-

pH not specified in the publication, 37°C, inhibition of human THP-1 cells

743716

0.0231

prostaglandin 15-oxo-PGF2alpha

Homo sapiens

-

pH not specified in the publication, 37°C, inhibition of human monocytes

743716

0.0074

prostaglandin 20-hydroxy PGE2

Homo sapiens

-

pH not specified in the publication, 37°C, inhibition of human THP-1 cells

743716

0.0112

prostaglandin 20-hydroxy PGE2

Homo sapiens

-

pH not specified in the publication, 37°C, inhibition of human monocytes

743716

0.0046

prostaglandin DELTA12-PGJ2

Homo sapiens

-

pH not specified in the publication, 37°C, inhibition of human monocytes

743716

0.0071

prostaglandin DELTA12-PGJ2

Homo sapiens

-

pH not specified in the publication, 37°C, inhibition of human THP-1 cells

743716

0.0049

prostaglandin PGA2

Homo sapiens

-

pH not specified in the publication, 37°C, inhibition of human monocytes

743716

0.0078

prostaglandin PGA2

Homo sapiens

-

pH not specified in the publication, 37°C, inhibition of human THP-1 cells

743716

0.0041

prostaglandin PGD2

Homo sapiens

-

pH not specified in the publication, 37°C, inhibition of human monocytes

743716

0.0074

prostaglandin PGD2

Homo sapiens

-

pH not specified in the publication, 37°C, inhibition of human THP-1 cells

743716

0.0047

prostaglandin PGD2 ethanolamide

Homo sapiens

-

pH not specified in the publication, 37°C, inhibition of human monocytes

743716

0.0057

prostaglandin PGD2 ethanolamide

Homo sapiens

-

pH not specified in the publication, 37°C, inhibition of human THP-1 cells

743716

0.01

prostaglandin PGE2

Homo sapiens

-

pH not specified in the publication, 37°C, inhibition of human THP-1 cells

743716

0.0221

prostaglandin PGE2

Homo sapiens

-

pH not specified in the publication, 37°C, inhibition of human monocytes

743716

0.0046

prostaglandin PGE2 ethanolamide

Homo sapiens

-

pH not specified in the publication, 37°C, inhibition of human THP-1 cells

743716

0.0063

prostaglandin PGE2 ethanolamide

Homo sapiens

-

pH not specified in the publication, 37°C, inhibition of human monocytes

743716

0.0071

prostaglandin PGF2beta

Homo sapiens

-

pH not specified in the publication, 37°C, inhibition of human monocytes

743716

0.0074

prostaglandin PGF2beta

Homo sapiens

-

pH not specified in the publication, 37°C, inhibition of human THP-1 cells

743716

0.0092

prostaglandin PGG2

Homo sapiens

-

pH not specified in the publication, 37°C, inhibition of human THP-1 cells

743716

0.0112

prostaglandin PGG2

Homo sapiens

-

pH not specified in the publication, 37°C, inhibition of human monocytes

743716

0.0072

prostaglandin PGH2

Homo sapiens

-

pH not specified in the publication, 37°C, inhibition of human THP-1 cells

743716

0.0096

prostaglandin PGH2

Homo sapiens

-

pH not specified in the publication, 37°C, inhibition of human monocytes

743716

0.0042

prostaglandin PGJ2

Homo sapiens

-

pH not specified in the publication, 37°C, inhibition of human monocytes

743716

0.0067

prostaglandin PGJ2

Homo sapiens

-

pH not specified in the publication, 37°C, inhibition of human THP-1 cells

743716

additional information

additional information

Mus musculus

-

review article sumarizing data of many inhibitors of indoleamine 2,3-dioxygenase

695525

-

additional information

additional information

Homo sapiens

P14902

review article sumarizing data of many inhibitors of indoleamine 2,3-dioxygenase

695525

-