1.13.11.6: 3-hydroxyanthranilate 3,4-dioxygenase

This is an abbreviated version!
For detailed information about 3-hydroxyanthranilate 3,4-dioxygenase, go to the full flat file.

Reaction

Synonyms

3-HAD, 3-HAO, 3-hydroxyanthranilate 3,4-dioxygenase, 3-hydroxyanthranilate oxygenase, 3-hydroxyanthranilic acid oxidase, 3-hydroxyanthranilic acid oxygenase, 3-hydroxyanthranilic oxygenase, 3HAO, EC 1.13.1.6, HAD, HAO, oxygenase, 3-hydroxyanthranilate 3,4-di-

ECTree

     1 Oxidoreductases

         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

             1.13.11 With incorporation of two atoms of oxygen

                1.13.11.6 3-hydroxyanthranilate 3,4-dioxygenase

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Results	in table
1	Activating Compound
5583	AA Sequence
4	Application
1	CAS Registry Number
8	Cloned(Commentary)
1	Cofactor
6	Crystallization (Commentary)
24	Disease/ Diagnostics
8	General Information
2	General Stability
35	Inhibitors
8	Ki Value [mM]
18	KM Value [mM]
3	Localization
20	Metals/Ions
15	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
2	Organic Solvent Stability
213	Organism
8	Pathway
39	PDB ID
6	pH Optimum
4	pH Range
2	pH Stability
2	pI Value
18	Protein Variants
13	Purification (Commentary)
4	Reaction
3	Reaction Type
36	Reference
20	Source Tissue
12	Specific Activity [micromol/min/mg]
8	Storage Stability
44	Substrates and Products (Substrate)
6	Subunits
22	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
2	Temperature Range [°C]
1	Temperature Stability [°C]
5	Turnover Number [1/s]

Disease

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Disease on EC 1.13.11.6 - 3-hydroxyanthranilate 3,4-dioxygenase

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DISEASE

TITLE OF PUBLICATION

LINK TO PUBMED

Carcinoma, Hepatocellular

Molecular cloning and functional expression of human 3-hydroxyanthranilic-acid dioxygenase.

7514594

Glioma

The endogenous tryptophan metabolite and NAD+ precursor quinolinic acid confers resistance of gliomas to oxidative stress.

23548271

Huntington Disease

3-Hydroxyanthranilate oxygenase activity is increased in the brains of Huntington disease victims.

2967497

Hyperglycemia

Changes in mouse liver and chicken embryo yolk sac membrane soluble proteins due to an organophosphorous insecticide (OPI) diazinon linked to several noncholinergic OPI effects in mice and chicken embryos.

25454523

Infections

Antiviral Effect of IDO in Mouse Fibroblast Cells During Influenza Virus Infection.

28402179

Lymphoma, B-Cell

Novel urine biomarkers to distinguish UTI from culture-negative pyuria.

34272611

Neurodegenerative Diseases

2-Aminonicotinic acid 1-oxides are chemically stable inhibitors of quinolinic acid synthesis in the mammalian brain: a step toward new antiexcitotoxic agents.

24274468

Olivopontocerebellar Atrophies

Quinolinic acid catabolism is increased in cerebellum of patients with dominantly inherited olivopontocerebellar atrophy.

1825460

Seizures

Anticonvulsant effects of the 3-hydroxyanthranilic acid dioxygenase inhibitor NCR-631.

11026503

Seizures

Differential expression of the astrocytic enzymes 3-hydroxyanthranilic acid oxygenase, kynurenine aminotransferase and glutamine synthetase in seizure-prone and non-epileptic mice.

7805640

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