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1.13.11.60: linoleate 8R-lipoxygenase

This is an abbreviated version!
For detailed information about linoleate 8R-lipoxygenase, go to the full flat file.

Word Map on EC 1.13.11.60

Reaction

linoleate
+
O2
=
(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate

Synonyms

5,8-LDS, 5,8-linoleate diol synthase, 6,8-diol synthase, 6R,8R-linoleate diol synthase, 6R,8RLDS, 7,8-diol synthase, 7,8-LDS, 7,8-linoleate diol synthase, 8(R)-dioxygenase, 8,11-hydroperoxide isomerase, 8-DOX, 8R-dioxygenase, 8R-DOX, 8R-DOX-5,8-LDS, 8R-DOX-7,8-LDS, 8R-DOX-LDS, dioxygenase-cytochrome P450, DOX-CYP, EC 1.13.11.44, EGE82165, FOXB_09952, GLRG_10013, linoleate 7,8-LDS, linoleate 8,11-LDS, linoleate diol synthase, linoleic acid 8R-dioxygenase, ODH51007, orphan DOX-CYP, PpoA

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
                1.13.11.60 linoleate 8R-lipoxygenase

KCat KM Value

KCat KM Value on EC 1.13.11.60 - linoleate 8R-lipoxygenase

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kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
261
(11Z)-icos-11-enoic acid
pH 7.2, 24°C
1813.5
(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate
recombinant enzyme, whole enzyme activity, pH 6.5, 40°C
340 - 954.54
alpha-linolenate
130
alpha-linolenic acid
-
full-length enzyme, at pH 6.5 and 25°C
508.4
arachidonate
recombinant enzyme, N-terminal domain activity, pH 6.5, 40°C
510
arachidonic acid
N-terminal 8-dioxygenase domain, pH 6.5, 40°C
466.1
dihomo-gamma-linolenate
recombinant enzyme, N-terminal domain activity, pH 6.5, 40°C
470
dihomo-gamma-linolenic acid
N-terminal 8-dioxygenase domain, pH 6.5, 40°C
554.9
eicosadienoate
recombinant enzyme, N-terminal domain activity, pH 6.5, 40°C
560
eicosadienoic acid
N-terminal 8-dioxygenase domain, pH 6.5, 40°C
679
eicosenoate
recombinant enzyme, N-terminal domain activity, pH 6.5, 40°C
680
eicosenoic acid
N-terminal 8-dioxygenase domain, pH 6.5, 40°C
344 - 1820
linoleate
1240
linoleic acid
-
full-length enzyme, at pH 6.5 and 25°C
170 - 843
oleate
1070
oleic acid
-
full-length enzyme, at pH 6.5 and 25°C
100 - 700
palmitoleate
450
palmitoleic acid
-
full-length enzyme, at pH 6.5 and 25°C