1.13.11.71: carotenoid-9',10'-cleaving dioxygenase

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For detailed information about carotenoid-9',10'-cleaving dioxygenase, go to the full flat file.

Reaction

Synonyms

BC-9',10'-oxygenase, Bcdo2, BCO2, beta,beta-carotene 9',10'-dioxygenase 2, beta,beta-carotene 9',10'-oxygenase, beta,beta-carotene-9',10'-dioxygenase, beta,beta-carotene-9',10'-dioxygenase 2, beta,beta-carotene-9,10-oxygenase 2, beta-carotene 9',10' oxygenase, beta-carotene 9',10'-oxygenase, beta-carotene-9',10'-oxygenase, beta-carotene-9,10'-oxygenase, CCD1, CCD4b, CCD7, LjCCD7, ScBCO2, xanthophyll cleavage enzyme

ECTree

     1 Oxidoreductases

         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

             1.13.11 With incorporation of two atoms of oxygen

                1.13.11.71 carotenoid-9',10'-cleaving dioxygenase

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Results	in table
4	Activating Compound
21	AA Sequence
4	Application
8	Cloned(Commentary)
5	Disease/ Diagnostics
3	Expression
30	General Information
6	Inhibitors
4	kcat/KM [mM/s]
5	KM Value [mM]
9	Localization
5	Metals/Ions
26	Natural Substrates/ Products (Substrates)
14	Organic Solvent Stability
30	Organism
1	Pathway
6	pH Optimum
1	pH Range
6	Protein Variants
3	Purification (Commentary)
1	Reaction
29	Reference
66	Source Tissue
1	Specific Activity [micromol/min/mg]
50	Substrates and Products (Substrate)
2	Subunits
47	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
1	Temperature Range [°C]
5	Temperature Stability [°C]
4	Turnover Number [1/s]

Expression

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Expression on EC 1.13.11.71 - carotenoid-9',10'-cleaving dioxygenase

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

a marked up-regulation of Bcdo2 expression in inguinal white adipose tissue of Bcmo1-null mice is shown, both with control and beta-carotene diet

Mus musculus

-

728552

expression of the bco2 gene is dramatically decreased in prostate cancer tissue and in a range of prostate cancer cell lines as compared with nonneoplastic prostate tissue and normal prostatic epithelial cells, respectively. Inhibition of DNA methyltransferase activity restores bco2 expression in prostate cancer cell lines tested

Homo sapiens

Q9BYV7

745753

treatment with lycopene or its metabolite, apo-10-lycopenal, increases bco2 expression and reduces cell proliferation in androgen-sensitive cell lines, but lycopene neither alters bco2 expression nor cell growth in androgen-resistant cells

Homo sapiens

Q9BYV7

745753