1.13.11.73: methylphosphonate synthase

This is an abbreviated version!
For detailed information about methylphosphonate synthase, go to the full flat file.

Word Map on EC 1.13.11.73

1.13.11.73

dioxygenase

oxygenases

nonheme

h-abstraction

methane

ocean

deprotonate

Reaction

Synonyms

methylphosphonate synthase, mpnS

ECTree

1 Oxidoreductases

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.13.11 With incorporation of two atoms of oxygen

1.13.11.73 methylphosphonate synthase

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Results	in table
6	AA Sequence
2	Cloned(Commentary)
1	Crystallization (Commentary)
3	General Information
3	kcat/KM [mM/s]
4	KM Value [mM]
6	Metals/Ions
4	Natural Substrates/ Products (Substrates)
6	Organism
5	Pathway
16	PDB ID
4	Protein Variants
1	Purification (Commentary)
3	Reaction
6	Reference
9	Substrates and Products (Substrate)
9	Synonyms
1	Systematic Name
3	Turnover Number [1/s]

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Reference on EC 1.13.11.73 - methylphosphonate synthase

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719659

Cooke, H.A.; Peck, S.C.; Evans, B.S.; van der Donk, W.A.

Mechanistic investigation of methylphosphonate synthase, a non-heme iron-dependent oxygenase

J. Am. Chem. Soc.

134

15660-15663

2012

Nitrosopumilus maritimus

22957470

721059

Metcalf, W.; Griffin, B.; Cicchillo, R.; Gao, J.; Janga, S.; Cooke, H.; Circello, B.; Evans, B.; Martens-Habbena, W.; Stahl, D.; Van Der Donk, W.

Synthesis of methylphosphonic acid by marine microbes: A source for methane in the aerobic ocean

Science

337

1104-1107

2012

Nitrosopumilus maritimus

22936780

745162

Peck, S.C.; Chekan, J.R.; Ulrich, E.C.; Nair, S.K.; van der Donk, W.A.

A common late-stage intermediate in catalysis by 2-hydroxyethyl-phosphonate dioxygenase and methylphosphonate synthase

J. Am. Chem. Soc.

137

3217-3220

2015

Streptomyces viridochromogenes

25699631

745390

Peck, S.C.; van der Donk, W.A.

Go it alone four-electron oxidations by mononuclear non-heme iron enzymes

J. Biol. Inorg. Chem.

381-394

2017

Nitrosopumilus maritimus

27783267

764510

Yan, J.F.; Chen, S.L.

How to produce methane precursor in the upper ocean by an untypical non-heme Fe-dependent methylphosphonate synthase?

ChemPhysChem

385-396

2020

Nitrosopumilus maritimus (A9A1T2)

31926045

764974

Wang, B.; Cao, Z.; Rovira, C.; Song, J.; Shaik, S.

Fenton-derived OH radicals enable the MPnS enzyme to convert 2-hydroxyethylphosphonate to methylphosphonate Insights from ab initio QM/MM MD simulations

J. Am. Chem. Soc.

141

9284-9291

2019

Nitrosopumilus maritimus (A9A1T2)

31132257