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1.13.11.74: 2-aminophenol 1,6-dioxygenase

This is an abbreviated version!
For detailed information about 2-aminophenol 1,6-dioxygenase, go to the full flat file.

Word Map on EC 1.13.11.74

Reaction

2-Aminophenol
+
O2
=
2-aminomuconate 6-semialdehyde

Synonyms

2-aminophenol-1,6-dioxygenase, amnA, amnB, amnBA, APD

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
                1.13.11.74 2-aminophenol 1,6-dioxygenase

Inhibitors

Inhibitors on EC 1.13.11.74 - 2-aminophenol 1,6-dioxygenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,2,3-trihydroxybenzene
-
complete inhibition at 0.05 mM
1,2,4-Trihydroxybenzene
2,2'-dipyridyl
2,3-Dihydroxybenzoic acid
-
20% inhibition at 0.05 mM
2-amino-p-cresol
-
90% inhibition at 0.05 mM
2-methoxyphenol
-
30% inhibition at 0.05 mM
3-Amino-4-hydroxybenzoic acid
-
20% inhibition at 0.05 mM
3-chlorocatechol
3-fluorocatechol
-
noncompetitive inhibition
3-hydroxyanthranilic acid
-
20% inhibition at 0.05 mM
3-methylcatechol
4-amino-3-hydroxybenzoic acid
-
30% inhibition at 0.05 mM
4-amino-m-cresol
-
10% inhibition at 0.05 mM
4-aminoresorcinol
4-Chlorocatechol
4-methylcatechol
4-nitrocatechol
5,5'-dithiobis-(2-nitrobenzoic acid)
-
complete inhibition at 0.5 mM
AgNO3
-
6% residual activity at 0.5 mM
catechol
Cu2+
2.9% residual activity at 2 mM
CuSO4
-
complete inhibition at 0.1 mM
Fe2+
57.4% residual activity at 2 mM
FeCl3
-
complete inhibition at 0.5 mM
FeSO4(NH4)2SO4
-
78% residual activity at 0.5 mM
HgCl2
-
12% residual activity at 0.5 mM
iodoacetate
-
40% residual activity at 0.5 mM
K3Fe(CN)6
MgSO4
-
79% residual activity at 0.5 mM
MnCl2
-
53% residual activity at 0.5 mM
Mo2+
-
96% residual activity at 2 mM
N-ethylmaleimide
-
83% residual activity at 0.5 mM
NaN3
-
complete inhibition at 0.5 mM
nitrilotriacetic acid
-
86% residual activity at 2 mM
o-phenanthroline
p-chloromercuribenzoic acid
-
65% residual activity at 0.5 mM
protocatechuate
-
20% inhibition at 0.05 mM
pyrogallol
-
noncompetitive inhibition
Tiron
-
complete inhibition at 0.5 mM
additional information
-
not inhibited by FeSO4
-