1.13.11.78: 2-amino-1-hydroxyethylphosphonate dioxygenase (glycine-forming)
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For detailed information about 2-amino-1-hydroxyethylphosphonate dioxygenase (glycine-forming), go to the full flat file.
Reaction
Synonyms
(R)-1-hydroxy-2-aminoethylphosphonate oxygenase, ALOHA_HF130_AEPn_1_06c, diiron oxygenase, phnZ
ECTree
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Metals Ions
Metals Ions on EC 1.13.11.78 - 2-amino-1-hydroxyethylphosphonate dioxygenase (glycine-forming)
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Fe2+
Iron
the enzyme contains 1.2 Fe per monomer, contains a dinuclear iron cluster. The mixed-valent FeII/FeIII state is the catalytically active cofactor form
Fe2+
required and involvedin catalysis. PhnZ is a nonheme diiron oxygenase
Fe2+
required for catalysis, the enzyme uses a diiron oxygenase mechanism. Residue Y24 forms a transient ligand interaction at the dioxygen binding site of the two Fe2+. The first Fe ion is coordinated in a distorted octahedral geometry by Y24, H34, H58, D59, D161, and the bridging water. PhnZ ligates the second Fe2+ ion in an octahedral geometry through interactions with D59, H80, H104, and the bridging water. The second Fe is further coordinated in a bidentate fashion by the adjacent carboxylate and alpha-hydroxyl oxygens of L-tartrate