1.13.11.80: (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase

This is an abbreviated version!
For detailed information about (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase, go to the full flat file.

Reaction

Synonyms

DpgC

ECTree

     1 Oxidoreductases

         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

             1.13.11 With incorporation of two atoms of oxygen

                1.13.11.80 (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase

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Results	in table
29	AA Sequence
5	Cloned(Commentary)
3	Cofactor
3	Crystallization (Commentary)
3	General Information
2	Inhibitors
14	kcat/KM [mM/s]
1	Ki Value [mM]
18	KM Value [mM]
2	Metals/Ions
1	Molecular Weight [Da]
7	Natural Substrates/ Products (Substrates)
14	Organism
2	Pathway
36	PDB ID
3	pH Optimum
18	Protein Variants
5	Purification (Commentary)
5	Reaction
8	Reference
20	Substrates and Products (Substrate)
4	Subunits
6	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
15	Turnover Number [1/s]

Engineering

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Engineering on EC 1.13.11.80 - (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase

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PROTEIN VARIANTS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

A319C

Streptomyces toyocaensis

Q8KLK7

the catalytic efficiency of the mutant is about 1.5% of that of the wild type protein

763838

E189Q

Streptomyces toyocaensis

Q8KLK7

kcat/KM for (3,5-dihydroxyphenyl)acetyl-CoA is 3% compared to the wild-type activity

729199

E255Q

Streptomyces toyocaensis

Q8KLK7

kcat/KM for (3,5-dihydroxyphenyl)acetyl-CoA is 96% compared to the wild-type activity

729199

L237T

Streptomyces toyocaensis

Q8KLK7

kcat/KM for (3,5-dihydroxyphenyl)acetyl-CoA is 2% compared to the wild-type activity

730462

Q299N

Streptomyces toyocaensis

Q8KLK7

kcat/KM for (3,5-dihydroxyphenyl)acetyl-CoA is 63% compared to the wild-type activity

729199

R254K

Streptomyces toyocaensis

Q8KLK7

kcat/KM for (3,5-dihydroxyphenyl)acetyl-CoA is 1% compared to the wild-type activity

729199

V425T

2 entries

V429T

Streptomyces toyocaensis

Q8KLK7

kcat/KM for (3,5-dihydroxyphenyl)acetyl-CoA is 3% compared to the wild-type activity

730462

A319C

Streptomyces toyocaensis A47934

-

the catalytic efficiency of the mutant is about 1.5% of that of the wild type protein

-

E189Q

Streptomyces toyocaensis A47934

-

kcat/KM for (3,5-dihydroxyphenyl)acetyl-CoA is 3% compared to the wild-type activity

-

E255Q

Streptomyces toyocaensis A47934

-

kcat/KM for (3,5-dihydroxyphenyl)acetyl-CoA is 96% compared to the wild-type activity

-

L237T

Streptomyces toyocaensis A47934

-

kcat/KM for (3,5-dihydroxyphenyl)acetyl-CoA is 2% compared to the wild-type activity

-

Q299N

Streptomyces toyocaensis A47934

-

kcat/KM for (3,5-dihydroxyphenyl)acetyl-CoA is 63% compared to the wild-type activity

-

R254K

Streptomyces toyocaensis A47934

-

kcat/KM for (3,5-dihydroxyphenyl)acetyl-CoA is 1% compared to the wild-type activity

-

V425T

2 entries

V429T

Streptomyces toyocaensis A47934

-

kcat/KM for (3,5-dihydroxyphenyl)acetyl-CoA is 3% compared to the wild-type activity

-

V425T

Streptomyces toyocaensis

Q8KLK7

the mutant shows reduced activity compared to the wild type enzyme

763838

V425T

Streptomyces toyocaensis

Q8KLK7

kcat/KM for (3,5-dihydroxyphenyl)acetyl-CoA is 6% compared to the wild-type activity

730462

V425T

Streptomyces toyocaensis A47934

-

kcat/KM for (3,5-dihydroxyphenyl)acetyl-CoA is 6% compared to the wild-type activity

-

V425T

Streptomyces toyocaensis A47934

-

the mutant shows reduced activity compared to the wild type enzyme

-