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1.13.12.2: lysine 2-monooxygenase

This is an abbreviated version!
For detailed information about lysine 2-monooxygenase, go to the full flat file.

Word Map on EC 1.13.12.2

Reaction

L-lysine
+
O2
=
5-Aminopentanamide
 +
CO2
 +
H2O

Synonyms

davB, L-AAO/MOG, L-amino acid oxidase/monooxygenase, L-LOX/MOG, L-lysine 2-monooxygenase, L-lysine monooxygenase, L-lysine oxidase/monooxygenase, L-lysine-2-monooxygenase, lysine monooxygenase, lysine oxygenase

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.12 With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)
                1.13.12.2 lysine 2-monooxygenase

Inhibitors

Inhibitors on EC 1.13.12.2 - lysine 2-monooxygenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2,2'-dipyridyl
-
-
2-oxoglutarate
-
60% inhibition at 5 mM
4-Methyllysine
-
at higher substrate concentrations, competitive inhibitor
5-Aminovaleramide
-
42% inhibition at 5 mM
5-Aminovalerate
-
36% inhibition at 5 mM
5-Methyllysine
-
at higher substrate concentrations, competitive inhibitor
8-hydroxyquinoline
-
-
acetate
-
38% inhibition at 5 mM
alkylamines
-
high concentration inhibits, low concentrations stimulate lysine oxygenation
citrate
-
76% inhibition at 5 mM
epsilon-aminocaproate
-
competitive inhibitor toward lysine
glutamate
-
42% inhibition at 5 mM
Glutarate
-
57% inhibition at 5 mM
Nepsilon-Methyllysine
-
at higher substrate concentrations, competitive inhibitor
o-Iodosobenzoate
-
-
ornithine
-
at low concentration of L-lysine reaction is stimulated by L-ornithine, at high concentrations of L-lysine it is inhibited
oxaloacetate
-
67% inhibition at 5 mM
p-chloromercuribenzoate
succinate
-
52% inhibition at 5 mM
sulfhydryl inhibitors
-
-
-
additional information
-