1.14.11.11: hyoscyamine (6S)-dioxygenase

This is an abbreviated version!
For detailed information about hyoscyamine (6S)-dioxygenase, go to the full flat file.

Word Map on EC 1.14.11.11

1.14.11.11

scopolamine

tropane

hyoscyamus

niger

belladonna

atropa

anisodus

anticholinergic

hairy

acutangulus

anisodamine

epoxidation

2-oxoglutarate-dependent

aerial

6beta-hydroxylase

solanaceous

tanguticus

agrobacterium-mediated

metel

putrescine

datura

n-methyltransferase

tabacum

chemotype

high-value

catharanthus

pericycle

roseus

tropinone

genetically-engineered

biofunctional

gst-tag

vindoline

underground

bolt

2.1.1.53

drug development

pharmacology

Reaction

Synonyms

6H6, AaH6H, AtH6H, Dih6h, H6H, HnH6H, hyoscyamine 6-hydroxylase, hyoscyamine 6beta-hydroxylase, hyoscyamine-6beta-hydroxylase, oxygenase, hyoscyamine 6beta-di-

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

1.14.11.11 hyoscyamine (6S)-dioxygenase

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Results	in table
39	Activating Compound
26	AA Sequence
4	Application
1	CAS Registry Number
23	Cloned(Commentary)
1	Crystallization (Commentary)
1	Expression
14	General Information
47	Inhibitors
2	kcat/KM [mM/s]
2	Ki Value [mM]
13	KM Value [mM]
14	Metals/Ions
12	Molecular Weight [Da]
20	Natural Substrates/ Products (Substrates)
8	Organic Solvent Stability
40	Organism
5	Pathway
5	pH Optimum
2	pH Range
3	pI Value
14	Protein Variants
9	Purification (Commentary)
2	Reaction
7	Reaction Type
40	Reference
41	Source Tissue
1	Specific Activity [micromol/min/mg]
3	Storage Stability
70	Substrates and Products (Substrate)
8	Subunits
45	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
2	Turnover Number [1/s]

Molecular Weight

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Molecular Weight on EC 1.14.11.11 - hyoscyamine (6S)-dioxygenase

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19000

Hyoscyamus niger

x * 39000 + x * 19000, SDS-PAGE

38700

x * 38700, SDS-PAGE

38768

calculated from sequence, predominantly exists as monomer (90%)

765317

38999

Hyoscyamus niger

x * 38999, calculation from nucleotide sequence

439276

39000

2 entries

39015

Hyoscyamus senecionis

J7HDC2

x * 39015, sequence calculation

726207

39238

Atropa belladonna

1 * 39238, recombinant enzyme, mass spectrometry, 1 * 39369, sequence calculation

724556

39369

Atropa belladonna

1 * 39238, recombinant enzyme, mass spectrometry, 1 * 39369, sequence calculation

41000

gel filtration

43000

x * 64000, recombinant GST-tagged enzyme, SDS-PAGE, x * 43000, recombinant His-tagged enzyme, SDS-PAGE

724637

64000

Anisodus acutangulus

x * 64000, recombinant GST-tagged enzyme, SDS-PAGE, x * 43000, recombinant His-tagged enzyme, SDS-PAGE

724637