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1.14.11.16: peptide-aspartate beta-dioxygenase

This is an abbreviated version!
For detailed information about peptide-aspartate beta-dioxygenase, go to the full flat file.

Word Map on EC 1.14.11.16

Reaction

peptide-L-aspartate
+
2-oxoglutarate
+
O2
=
peptide-3-hydroxy-L-aspartate
+
succinate
+
CO2

Synonyms

AAH, asparaginyl hydroxylase factor inhibiting HIF-1, aspartate beta-hydroxylase, aspartate-beta-hydroxylase, aspartate/asparagine-beta-hydroxylase, aspartyl (asparaginyl) beta-hydroxylase, aspartyl (asparaginyl)-beta-hydroxylase, aspartyl beta-hydroxylase, aspartyl-(asparaginyl) beta-hydroxylase, aspartyl-(asparaginyl)-b-hydroxylase, aspartyl-(asparaginyl)-beta-hydroxylase, aspartyl-(asparagyl)-beta-hydroxylase, aspartyl-asparaginyl-beta-hydroxylase, aspartyl/asparaginyl beta-hydroxylase, aspartylpeptide beta-dioxygenase, ASPH, EGF beta-hydroxylase, EGFH, factor inhibiting HIF, factor inhibiting hypoxia-inducible factor, factor inhibiting hypoxia-inducible transcription factor (HIF), factor-inhibiting hypoxia-inducible factor, FIH, HAAH, HIF asparaginyl hydroxylase, human aspartyl (asparaginyl) beta-hydroxylase, hypoxia-inducible factor asparaginyl hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.16 peptide-aspartate beta-dioxygenase

KM Value

KM Value on EC 1.14.11.16 - peptide-aspartate beta-dioxygenase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0006 - 0.125
2-oxoglutarate
0.003 - 0.093
Fe2+
0.019 - 0.075
first growth factor-like domain-L-aspartate
-
0.1
HIF-1alpha peptide Asp788-Leu822 (L-asparagine803)
pH 7.8, 30°C
-
0.09 - 0.426
O2
0.086
[factor X first EGF-like domain]-L-aspartate
pH and temperature not specified in the publication
-
0.0012
[thioether-linked cyclic peptide hFX-CP101-119]-L-aspartate
pH 7.5, 20°C
-