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1.14.11.2: procollagen-proline 4-dioxygenase

This is an abbreviated version!
For detailed information about procollagen-proline 4-dioxygenase, go to the full flat file.

Word Map on EC 1.14.11.2

Reaction

Procollagen L-proline
+
2-oxoglutarate
+
O2
=
procollagen trans-4-hydroxy-L-proline
+
succinate
+
CO2

Synonyms

A085R, alpha (I) subunit, anthrax-P4H, AT-P4H-1, At-P4H-2, BaP4H, C-P4H, C-P4H alpha subunit (III), C-P4H alpha(I), C-P4H alpha(III), CePHY-1/PHY-2/PDI2, collagen proline hydroxylase, collagen prolyl 4-hydroxylase, collagen prolyl 4-hydroxylase (type-II), collagen prolyl 4-hydroxylase 1, collagen prolyl-4-hydroxylase, collagen prolyl-4-hydroxylase alpha subunit 2, CP4H, CP4H1, CrP4H-1, DmP4H, egg-laying abnormal-9 prolyl hydroxylase, Egl nine homolog, EGLN, EGLN prolyl hydroxylase, EGLN3, EGLN3 hydroxylase, GBAA_4459, HIF prolyl hydroxylase, HIF prolyl-4-hydroxylase, HIF-1alpha-specific prolyl-hydroxylase, HIF-P4H-1, HIF-P4H-2, HIF-P4H-3, HPH, HPH-2, HuPH4-I, HuPH4-II, hydroxylase, collagen proline, hypoxia inducible factor prolyl-4-hydroxylase domain-containing protein, hypoxia inducible factor-prolyl hydroxylase, hypoxia-inducible factor -1alpha-type prolyl 4-hydroxylase, hypoxia-inducible factor prolyl hydroxylase, hypoxia-inducible factor-1alpha-prolyl-hydroxylase 2, More, NtP4H1.1, P4H, P4H alpha1, P4H-1, P4H1, P4ha1, P4ha2, P4Halpha(I), P4Halpha(II), P4Halpha(III), P4Halpha1, PBCV-1 P4H, peptidyl proline hydroxylase, PH, PHD, PHD-1, PHD1, PHD2, PHD3, procollagen prolyl 4-hydroxylase, procollagen-proline dioxygenase, proline 4-hydroxylase, proline hydroxylase, proline protocollagen hydroxylase, proline, 2-oxoglutarate dioxygenase, proline,2-oxoglutarate 4-dioxygenase, prolyl 4-hydroxylase, prolyl 4-hydroxylase A085R, prolyl hydroxylase, prolyl hydroxylase domain 1, prolyl hydroxylase domain containing protein, prolyl hydroxylase domain enzyme, prolyl hydroxylase domain protein 2, prolyl hydroxylase-1, prolyl hydroxylase-3, prolyl-4-hydroxylase, prolyl-4-hydroxylase alpha I, prolyl-4-hydroxylase alpha II, prolyl-4-hydroxylase alpha subunit 2, prolyl-4-hydroxylase alpha1, prolyl-4-hydroxylase-alpha1, prolyl-4-hydroxylases, prolyl-glycyl-peptide, 2-oxoglutarate:oxygen oxidoreductase, 4-hydroxylating, prolyl4-hydroxylase, prolylprotocollagen dioxygenase, prolylprotocollagen hydroxylase, protocollagen hydroxylase, protocollagen proline 4-hydroxylase, protocollagen proline dioxygenase, protocollagen proline hydroxylase, protocollagen prolyl hydroxylase, PSB-II, Skp1 prolyl hydroxylase, type I C-P4H, type I proly 4-hydroxylase, type I proyl 4-hydroxylase, type II proyl 4-hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.2 procollagen-proline 4-dioxygenase

KI Value

KI Value on EC 1.14.11.2 - procollagen-proline 4-dioxygenase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
20
(+)-mandelate
-
value above
20
(-)-mandelate
-
value above
0.03
1,2,3-trihydroxybenzene
-
-
0.025
1,2-dihydroxybenzene
-
-
10.2
1,3-dihydroxybenzene
-
-
0.00065
1,4-dihydrophenanthroline-4-one-3-carboxylic acid
-
purified enzyme
14
1,4-dihydroxybenzene
-
-
0.07
2,3-Dihydroxybenzoate
-
-
0.53
2,4-Dihydroxybenzoate
-
-
1.4
2,5-Dihydroxybenzoate
-
-
1.1
2,6-dihydroxybenzoate
-
-
0.0403
2,7,8-trihydroxyanthraquinone
-
-
2.3
2-Hydroxybenzoate
-
-
0.2 - 0.9
2-oxoadipinate
7.6
2-oxobutyrate
-
-
0.1 - 0.4
2-oxosuccinate
9.4
2-oxovalerate
-
-
0.03
3,4,5-Trihydroxybenzoate
-
-
0.005 - 0.07
3,4-dihydroxybenzoate
0.005 - 0.3
3,4-dihydroxybenzoic acid
0.018
3,4-dihydroxycinnamate
-
-
0.009
3,4-dihydroxymandelate
-
-
0.009 - 0.04
3,4-Dihydroxyphenylacetate
0.013 - 0.024
3,4-Dihydroxyphenylpropionate
9
3,5-Dihydroxybenzoate
-
-
0.002 - 0.03
3-carboxy-4-oxo-3,4-dihydro-1,10-phenanthroline
20
3-hydroxybenzoate
-
value above
0.0004 - 0.015
3-hydroxypyridine-2-carbonyl-glycine
0.8
3-oxoglutarate
-
-
3.2
4-hydroxybenzoate
0.09
5-Azidopyridine-2-carboxylic acid
-
-
0.0000166
8-(N-butyl-N-ethylcarbamoyl)-1,4-dihydrophenanthrolin-4-one-3-carboxylic acid
-
purified enzyme
15
adipinate
-
value above
7
ascorbate
-
-
10
benzene 1,2-dicarboxylate
-
value above
5.8 - 11
Benzene 1,3-dicarboxylate
3.3
Benzene 1,4-dicarboxylate
-
-
9.9
benzoate
-
-
0.4 - 0.5
citrate
-
calculated from the slopes or intercepts
40 - 180
Collagen
17
Coumalic acid
0.04
doxorubicin
0.1
epinephrine
-
-
0.02 - 0.6
Fe2+
0.05 - 0.6
fumarate
1.5 - 4.2
Glutarate
1.5 - 2.1
isocitrate
-
calculated from the slopes or intercepts
20
L-galactono gamma-lactone
-
value above
15
levulinate
-
value above
1.2 - 1.3
malate
-
calculated from the slopes or intercepts
5.9
malonate
-
-
0.00006 - 0.0008
N-((3-hydroxy-6-chloroquinolin-2-yl)carbonyl)glycine
0.0002 - 0.0008
N-[(6-chloro-3-hydroxyquinolin-2-yl)carbonyl]glycine
0.04
nitroblue tetrazolium
-
-
0.008 - 0.05
oxalglycine
0.6
oxaloacetate
-
-
1.4
oxalyl-beta-alanine
-
-
0.04
oxalylalanine
-
-
1.25
oxalylcystine
-
-
0.0004 - 0.05
oxalylglycine
10
oxalylproline
-
value above
1
oxalylsarcosine
-
-
10
oxalylvaline
-
value above
20
phenylacetate
-
value above
0.0000162
phosphoribosyl adenosine monophosphate
-
-
0.00002 - 0.3
poly (L-proline)
-
0.0000015
Poly(ADP-ribose)
-
-
3
poly(L-hydroxyproline)
-
-
-
0.00002 - 2.5
poly(L-proline)
-
0.21
pyridine 2,3-dicarboxylate
-
-
0.001 - 0.04
Pyridine 2,4-dicarboxylate
0.0008 - 0.3
Pyridine 2,5-dicarboxylate
0.025 - 0.05
pyridine 2-carboxylate
2.2
Pyridine 3,4-dicarboxylate
-
-
0.9
Pyridine 3,5-dicarboxylate
-
-
0.5
pyridine 3-carboxylate
-
-
0.9
Pyridine 4-carboxylate
-
-
0.002 - 0.07
Pyridine-2,4-dicarboxylate
0.0008 - 0.1
Pyridine-2,5-dicarboxylate
15 - 20
pyruvate
0.0000162
Ribosyl-ribosyl-adenine
-
-
0.35 - 1.6
succinate
0.0006 - 0.01
Zn2+