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0.02
(Ala-Thr-Pro-Pro-Pro-Val)3
-
1.26
(ATPPPV)3
-
sequence present in arabinogalactan protein
0.95
(L-Pro-L-Ala-L-Pro-L-Lys)2
-
recombinant enzyme
-
0.09 - 0.31
(L-Pro-L-Ala-L-Pro-L-Lys)3
-
0.25
(L-Pro-L-Glu-L-Pro-L-Pro-L-Ala)5 L-proline
-
complex of recombinant subunits PHY-4.1 and PDI2
0.01 - 2.9
(L-Pro-L-Pro-Gly)10
-
2.5
(L-Pro-L-Pro-Gly)10 L-proline
-
complex of recombinant subunits PHY-4.1 and PDI2
2.6
(L-Pro-L-Pro-Gly)2
-
-
-
0.1 - 1.8
(L-Pro-L-Pro-Gly)5
-
0.12
(L-Ser-L-Pro)19 L-proline
-
-
0.1
(L-Ser-L-Pro-L-Ala-L-Pro-L-Pro)5 L-proline
-
-
0.1
(L-Ser-L-Pro-L-Glu-L-Pro-L-Pro)5 L-proline
-
-
0.1
(L-Ser-L-Pro-L-Lys-L-Pro-L-Pro)5 L-proline
-
-
0.002 - 0.02
(Pro-Ala-Pro-Lys)10
0.09
(Pro-Ala-Pro-Lys)3
-
0.05
(Pro-Ala-Pro-Lys)5
-
recombinant enzyme
0.004 - 1
(Pro-Glu-Pro-Pro-Ala)5
0.01 - 1.27
(Pro-Pro-Gly)10
1.5
(Pro-Pro-Gly)10 L-proline
-
-
0.02
(Ser-Pro-Lys-Pro-Pro)5
0.006
100-amino acid alpha1(I) collagen fragment
-
PHY-1/PHY-2/(PDI-2)2 P4H tetramer
-
0.0002
510-amino acid alpha1(I) collagen fragment
-
PHY-1/PHY-2/(PDI-2)2 P4H tetramer
-
0.1 - 0.5
carboxymethylated collagen L-proline
-
0.001 - 0.0042
DALTLLAPAAGDTIISLDYG
0.13 - 0.38
DALTLLAPAAGDTIISLFG
0.078
dansyl-Gly-Phe-Pro-Gly-OEt
-
-
0.001 - 0.0042
DLDLEALAPYIPADDDFQL
0.01 - 0.02
DLDLEMLAPAIPMDDDFQL
0.05
DLDLEMLAPAIPMDDDFQLRSFDQ
-
0.02
DLDLEMLAPGIPMDDDFQL
C-terminal hydroxylation site of HIF-1alpha
0.03 - 0.1
DLDLEMLAPYIPMD
0.009 - 0.1
DLDLEMLAPYIPMDD
0.007 - 0.07
DLDLEMLAPYIPMDDDF
0.007 - 0.008
DLDLEMLAPYIPMDDDFQL
0.006 - 0.008
DLDLEMLAPYIPMDDDFQLRSFDQ
0.007 - 0.014
DLEMLAPYIPMDDDFQL
0.007 - 0.08
EMLAPYIPMDDDFQL
7.8 - 22
Gly-Val-Pro-Gly-Val
4.8
L-Pro-L-Ala-L-Pro-L-Lys
-
recombinant enzyme
-
8.6
Lys-Pro-Ala
-
recombinant enzyme
0.0000025
lysine hydroxylated protocollagen
-
-
-
0.5 - 1.2
PEG-Gly-Tyr-4-fluoroproline-GlyOEt
0.03
peptidyl L-proline
-
-
-
0.03 - 0.13
poly L-proline
-
6.4
poly(ethylene glycol)-Gly-L-Tyr-(2S)-4-thiaproline-Gly-OCH2CH2OH
-
30°C, pH 7.8
1.6
poly(ethylene glycol)-Gly-L-Tyr-L-(2S,4S)-4-fluoroproline-Gly-OCH2CH2OH
-
30°C, pH 7.8
0.58
poly(ethylene glycol)-Gly-L-Tyr-L-Pro-Gly-OCH2CH2OH
-
30°C, pH 7.8
0.0002 - 1.59
poly(L-proline)
-
0.0000016
Procollagen L-proline
-
-
0.00000001 - 0.005
Protocollagen
-
0.0002
protocollagen type I L-proline
-
0.01
Ser-Pro-Pro-Pro-Pro-Val-Ser-Pro-Pro-Pro-Val-Ser-Pro-Pro-Pro-Pro-Val
-
0.04
Ser-Pro-Pro-Pro-Val-Tyr-Lys-Ser-Pro-Pro-Pro-Pro-Val-Lys-His-Tyr-Ser-Pro-Pro-Pro-Val
-
0.66
SPPPPVSPPPVSPPPPV
-
sequence present in extensin
0.38
SPPPPVYKSPPPPVKHYSPPPV
-
sequence present in extensin
22.2
tert-butyloxycarbonyl-Gly-Val-Pro-Gly-Val-OH
-
-
37.2
tert-butyloxycarbonyl-L-Pro-L-Pro-Gly
-
-
-
24
tert-butyloxycarbonyl-Pro-Pro-Ala-Pro-OH
-
-
32.2
tert-butyloxycarbonyl-Pro-Pro-Gln-Pro-OCH3
-
-
38.9
tert-butyloxycarbonyl-Pro-Pro-Gly-Pro-OH
-
-
37.4
tert-butyloxycarbonyl-Pro-Pro-Gly-Pro-Pro-OH
-
-
10.7
tert-butyloxycarbonyl-Val-Pro-Gly-Val-OH
-
-
additional information
additional information
-
0.09
(L-Pro-L-Ala-L-Pro-L-Lys)3
isoform P4H1
-
0.09
(L-Pro-L-Ala-L-Pro-L-Lys)3
isoform P4H4
-
0.09
(L-Pro-L-Ala-L-Pro-L-Lys)3
isoform P4H7
-
0.31
(L-Pro-L-Ala-L-Pro-L-Lys)3
-
recombinant enzyme
-
0.01 - 0.03
(L-Pro-L-Pro-Gly)10
-
-
-
0.01 - 0.03
(L-Pro-L-Pro-Gly)10
-
-
-
0.015
(L-Pro-L-Pro-Gly)10
-
recombinant enzyme
-
0.018
(L-Pro-L-Pro-Gly)10
-
-
-
0.018
(L-Pro-L-Pro-Gly)10
-
-
0.02
(L-Pro-L-Pro-Gly)10
-
-
0.025
(L-Pro-L-Pro-Gly)10
-
PHY-1/PHY-2/(PDI-2)2 P4H tetramer
-
0.045
(L-Pro-L-Pro-Gly)10
-
recombinant type II enzyme tetramer
-
0.05
(L-Pro-L-Pro-Gly)10
-
-
-
0.06
(L-Pro-L-Pro-Gly)10
-
-
-
0.06
(L-Pro-L-Pro-Gly)10
isoform P4H1
-
0.06
(L-Pro-L-Pro-Gly)10
isoform P4H4
-
0.06
(L-Pro-L-Pro-Gly)10
isoform P4H7
-
0.095
(L-Pro-L-Pro-Gly)10
-
-
0.17
(L-Pro-L-Pro-Gly)10
-
-
-
0.26
(L-Pro-L-Pro-Gly)10
-
-
-
2.9
(L-Pro-L-Pro-Gly)10
Paramecium bursaria Chlorella virus-1
-
-
-
2.9
(L-Pro-L-Pro-Gly)10
-
recombinant enzyme
-
0.1 - 0.5
(L-Pro-L-Pro-Gly)5
-
-
-
0.1 - 0.5
(L-Pro-L-Pro-Gly)5
-
-
-
0.1 - 0.5
(L-Pro-L-Pro-Gly)5
-
-
-
0.12
(L-Pro-L-Pro-Gly)5
isoform P4H1
-
0.12
(L-Pro-L-Pro-Gly)5
isoform P4H4
-
0.12
(L-Pro-L-Pro-Gly)5
isoform P4H7
-
0.4 - 0.5
(L-Pro-L-Pro-Gly)5
-
-
-
0.66
(L-Pro-L-Pro-Gly)5
-
PHY-1/PHY-2/(PDI-2)2 P4H tetramer
-
1.8
(L-Pro-L-Pro-Gly)5
-
-
-
1.8
(L-Pro-L-Pro-Gly)5
-
-
-
1.8
(L-Pro-L-Pro-Gly)5
-
O2 with cosubstrate polyprolin
-
0.002
(Pro-Ala-Pro-Lys)10
-
0.02
(Pro-Ala-Pro-Lys)10
-
recombinant enzyme
0.004
(Pro-Glu-Pro-Pro-Ala)5
-
1
(Pro-Glu-Pro-Pro-Ala)5
-
recombinant enzyme
0.01 - 0.03
(Pro-Pro-Gly)10
-
-
0.011
(Pro-Pro-Gly)10
-
-
0.018
(Pro-Pro-Gly)10
-
type I enzyme tetramer
0.018
(Pro-Pro-Gly)10
-
wild-type enzyme tetramer and enzyme tetramer containing the H501S mutant alpha subunit
0.018
(Pro-Pro-Gly)10
type I enzyme
0.021
(Pro-Pro-Gly)10
-
type I enzyme
0.088
(Pro-Pro-Gly)10
-
type I enzyme
0.095
(Pro-Pro-Gly)10
type II enzyme
0.83
(Pro-Pro-Gly)10
-
mutant S78T
0.93
(Pro-Pro-Gly)10
-
wild-type enzyme
1.05
(Pro-Pro-Gly)10
-
mutant S87L
1.27
(Pro-Pro-Gly)10
-
mutant S78T/S87L
0.14
(Ser-Pro)5
-
mutant S78T/S87L
0.19
(Ser-Pro)5
-
mutant S78T
0.38
(Ser-Pro)5
-
wild-type enzyme
0.78
(Ser-Pro)5
-
mutant S87L
0.02
(Ser-Pro-Lys-Pro-Pro)5
-
0.02
(Ser-Pro-Lys-Pro-Pro)5
-
recombinant enzyme
0.001
2-oxoglutarate
-
with substrate HIF, isozyme P4H-II
0.002
2-oxoglutarate
-
with substrate HIF, isozyme P4H-I
0.005
2-oxoglutarate
-
biological substrate
0.012
2-oxoglutarate
-
recombinant type II enzyme tetramer
0.012
2-oxoglutarate
-
with substrate HIF, isozyme P4H-III
0.02
2-oxoglutarate
Paramecium bursaria Chlorella virus-1
-
-
0.02
2-oxoglutarate
-
recombinant enzyme
0.02
2-oxoglutarate
-
recombinant enzyme
0.02
2-oxoglutarate
-
partial reaction or complete reaction with in the presence of (Pro-Pro-Gly)n as a peptide substrate
0.02
2-oxoglutarate
-
with substrate procollagen, isozymes P4H-I and P4H-III
0.022
2-oxoglutarate
-
synthetic substrate
0.022
2-oxoglutarate
-
type I enzyme tetramer
0.022
2-oxoglutarate
type I and type II enzyme
0.022
2-oxoglutarate
-
type I and type II enzymes
0.022
2-oxoglutarate
-
with substrate procollagen, isozyme P4H-II
0.03
2-oxoglutarate
-
complex of recombinant subunits PHY-4.1 and PDI2
0.05
2-oxoglutarate
-
wild-type enzyme tetramer
0.084
2-oxoglutarate
-
wild-type enzyme
0.106
2-oxoglutarate
-
R490H mutant
0.106
2-oxoglutarate
-
R490S mutant
0.13
2-oxoglutarate
-
mutant W99A
0.14
2-oxoglutarate
-
mutant W243A
0.15
2-oxoglutarate
-
enzyme tetramer containing the H501S mutant alpha subunit
0.15
2-oxoglutarate
-
mutant Q130A
0.16
2-oxoglutarate
-
wild-type
0.57
2-oxoglutarate
-
mutant Y168F
1
2-oxoglutarate
-
mutant Y134F
0.14
ascorbate
-
0.3
ascorbate
Paramecium bursaria Chlorella virus-1
-
-
0.1 - 0.5
carboxymethylated collagen L-proline
-
-
-
0.14
carboxymethylated collagen L-proline
-
as cosubstrate
-
0.001
DALTLLAPAAGDTIISLDYG
-
substrate: NODD peptide, pH 7, 37°C, without NaCl
0.0042
DALTLLAPAAGDTIISLDYG
-
substrate: NODD peptide, pH 7, 37°C, 100 mM NaCl
0.13
DALTLLAPAAGDTIISLFG
N-terminal hydroxylation site of HIF-1alpha
0.38
DALTLLAPAAGDTIISLFG
N-terminal hydroxylation site of HIF-1alpha
0.001
DLDLEALAPYIPADDDFQL
-
substrate: CODD peptide, pH 7, 37°C, without NaCl
0.0042
DLDLEALAPYIPADDDFQL
-
substrate: CODD peptide, pH 7, 37°C, 100 mM NaCl
0.01
DLDLEMLAPAIPMDDDFQL
C-terminal hydroxylation site of HIF-1alpha
0.02
DLDLEMLAPAIPMDDDFQL
C-terminal hydroxylation site of HIF-1alpha
0.03
DLDLEMLAPYIPMD
-
0.009
DLDLEMLAPYIPMDD
-
0.007
DLDLEMLAPYIPMDDDF
-
0.007
DLDLEMLAPYIPMDDDFQL
-
0.008
DLDLEMLAPYIPMDDDFQL
-
0.006
DLDLEMLAPYIPMDDDFQLRSFDQ
-
0.008
DLDLEMLAPYIPMDDDFQLRSFDQ
-
0.007
DLEMLAPYIPMDDDFQL
-
0.014
DLEMLAPYIPMDDDFQL
-
0.007
EMLAPYIPMDDDFQL
-
0.0004
Fe2+
Paramecium bursaria Chlorella virus-1
-
-
7.8
Gly-Val-Pro-Gly-Val
type I enzyme
22
Gly-Val-Pro-Gly-Val
type II enzyme
20
L-Pro-L-Pro-Gly
-
-
-
0.03
O2
-
-
0.04
O2
-
with substrate procollagen, isozyme P4H-I
0.043
O2
-
synthetic substrate
0.065 - 0.25
O2
-
with substrate HIF at different fragment lengths, isozyme P4H-II
0.19
O2
-
complete reaction with (Pro-Pro-Gly)5 as a peptide substrate
0.23
O2
-
with substrate HIF, isozymes P4H-I and P4H-III
1.5
O2
-
partial reaction
0.5
PEG-Gly-Tyr-4-fluoroproline-GlyOEt
-
pH 7.8, 22°C, recombinant enzyme, fluoride-based assay
1.2
PEG-Gly-Tyr-4-fluoroproline-GlyOEt
-
pH 7.8, 22°C, recombinant enzyme, HPLC-based assay
0.03
poly L-proline
-
molecular weight 5000-10000 Da
-
0.13
poly L-proline
-
molecular weight 30000-40000 Da
-
0.002
poly(L-Pro)
-
MW 7000
0.005
poly(L-Pro)
-
MW 30000
0.007
poly(L-Pro)
-
MW 31000
0.011
poly(L-Pro)
-
MW 19000
0.023
poly(L-Pro)
-
MW 7000
0.025
poly(L-Pro)
-
Mr 30000-40000 da, complex of recombinant subunits PHY-4.1 and PDI2
0.11
poly(L-Pro)
-
Mr 30000-40000 da, complex of recombinant subunits PHY-4.1 and PDI2
0.14
poly(L-Pro)
-
Mr 5000-10000 Da, complex of recombinant subunits PHY-4.1 and PDI2
0.22
poly(L-Pro)
-
Mr 5000-10000 Da, complex of recombinant subunits PHY-4.1 and PDI2
0.25
poly(L-Pro)
-
wild-type
0.27
poly(L-Pro)
-
mutant Y168F
0.28
poly(L-Pro)
-
mutant W243A
0.28
poly(L-Pro)
-
mutant Y134F
0.46
poly(L-Pro)
-
mutant Q130A
0.65
poly(L-Pro)
-
mutant W99A
0.0002
poly(L-proline)
-
-
0.0002
poly(L-proline)
MW: 10000-20000
-
0.0002
poly(L-proline)
-
molecular weight 20000-40000 Da
-
0.0002
poly(L-proline)
isoform P4H1
-
0.0002
poly(L-proline)
isoform P4H4
-
0.0002
poly(L-proline)
isoform P4H7
-
0.002
poly(L-proline)
-
-
0.002
poly(L-proline)
MW: 5000-10000
-
0.002
poly(L-proline)
-
molecular weight 5000-10000 Da
-
0.002
poly(L-proline)
isoform P4H1
-
0.002
poly(L-proline)
isoform P4H4
-
0.002
poly(L-proline)
isoform P4H7
-
0.01
poly(L-proline)
-
-
-
0.1
poly(L-proline)
-
MW: 40000, recombinant enzyme
-
0.1
poly(L-proline)
Paramecium bursaria Chlorella virus-1
-
molecular weight 20000-40000 Da
-
0.11
poly(L-proline)
-
mutant S78T
-
0.23
poly(L-proline)
-
-
-
0.26
poly(L-proline)
-
mutant S87L
-
0.29
poly(L-proline)
-
wild-type enzyme
-
0.34
poly(L-proline)
-
mutant Y140F
-
0.35
poly(L-proline)
-
mutant S78T/S87L
-
0.5
poly(L-proline)
-
MW: 13000, recombinant enzyme
-
0.56
poly(L-proline)
-
mutant D149N
-
0.63
poly(L-proline)
-
mutant D149A
-
0.77
poly(L-proline)
-
mutant S84A
-
0.88
poly(L-proline)
-
mutant D81A
-
0.94
poly(L-proline)
-
mutant G85A
-
1.59
poly(L-proline)
-
mutant N152A
-
0.00000001
Protocollagen
-
-
-
0.00000001
Protocollagen
-
-
-
0.00000001
Protocollagen
-
-
-
0.000002
Protocollagen
-
random-coil from of substrate
-
0.0000024
Protocollagen
-
-
-
0.0002
Protocollagen
type I enzyme
-
0.0011
Protocollagen
type II enzyme
-
0.005
Protocollagen
-
-
-
0.0002
protocollagen type I L-proline
-
-
-
0.0002
protocollagen type I L-proline
-
-
-
additional information
additional information
-
-
-
additional information
additional information
-
-
-
additional information
additional information
-
-
-
additional information
additional information
-
-
-
additional information
additional information
-
-
-
additional information
additional information
kinetic analysis
-
additional information
additional information
-
kinetic analysis
-
additional information
additional information
-
effect of amino acids in other parts of the peptide chain, effect of peptide chain length and asymmetry in the hydroxylation of (Pro-Pro-Gly)n
-
additional information
additional information
-
effect of amino acids in other parts of the peptide chain, effect of peptide chain length and asymmetry in the hydroxylation of (Pro-Pro-Gly)n
-
additional information
additional information
-
Km decreases markedly with chain-length, it remains the same for the triple-helical conformation and for the random-coil form, and decreases by the presence of a basic amino acid in the NH2-terminal end
-
additional information
additional information
-
effect of photoaffinity labeling with N-(4-azido-2-nitrophenyl)glycyl-(Pro-Pro-Gly)5, substrates: (Pro-Pro-Gly)5 or procollagen
-
additional information
additional information
-
Km values of enzyme for peptides representing transcription factor HIF alpha sequences and containing only one proline residue
-
additional information
additional information
Km values of enzyme for peptides representing transcription factor HIF alpha sequences and containing only one proline residue
-
additional information
additional information
Km values of enzyme for peptides representing transcription factor HIF alpha sequences and containing only one proline residue
-
additional information
additional information
Km values of enzyme for peptides representing transcription factor HIF alpha sequences and containing only one proline residue
-
additional information
additional information
-
steady-state kinetics
-
additional information
additional information
-
Michalis-Menten kinetics
-