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1.14.11.26: deacetoxycephalosporin-C hydroxylase

This is an abbreviated version!
For detailed information about deacetoxycephalosporin-C hydroxylase, go to the full flat file.

Word Map on EC 1.14.11.26

Reaction

deacetoxycephalosporin C
+
2-oxoglutarate
+
O2
=
deacetylcephalosporin C
+
succinate
+
CO2

Synonyms

cefF, Cephalosporin biosynthesis expandase/hydroxylase, DACS, DAOC hydroxylase, DAOC synthase, DAOC/DAC synthase, DAOCS, deacetoxycephalosporin C hydroxylase, deacetoxycephalosporin C synthase, deacetylcephalosporin C synthase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.26 deacetoxycephalosporin-C hydroxylase

Substrates Products

Substrates Products on EC 1.14.11.26 - deacetoxycephalosporin-C hydroxylase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
3'-methylcephem + 2-oxoglutarate + O2
3'-hydroxymethylcephem + succinate + CO2
show the reaction diagram
-
-
-
-
?
3-exo-methylenecephalosporin C + 2-oxoglutarate + O2
deacetoxycephalosporin C + succinate + CO2
show the reaction diagram
-
37% of activity with deacetoxycephalosporin C
-
-
?
3-exomethylenecephalosporin + 2-oxoglutarate + O2
deacetoxycephalosporin C + succinate + CO2 + H2O
show the reaction diagram
-
-
-
-
?
3-exomethylenecephalosporin C + 2-oxoglutarate + O2
deacetylcephalosporin C + succinate + CO2 + H2O
show the reaction diagram
-
-
-
-
?
7-aminodeacetoxycephalosporanic acid + 2-oxoglutarate + O2
7-aminodeacetylcephalosporin + succinate + CO2
show the reaction diagram
ampicillin + 2-oxoglutarate + O2
? + succinate + CO2
show the reaction diagram
-
-
-
-
?
cephalexin + 2-oxoglutarate + O2
? + succinate + CO2
show the reaction diagram
-
-
-
-
?
cephalosporin G + 2-oxoglutarate + O2
deacetylcephalosporin G + succinate + CO2
show the reaction diagram
deacetoxycephalosporin C + 2-oxoglutarate + O2
deacetylcephalosporin C + succinate + CO2
show the reaction diagram
deacetoxycephalosporin C + 2-oxoglutarate + O2
deacetylcephalosporin C + succinate + CO2 + H2O
show the reaction diagram
-
-
-
-
?
penicillin G + 2-oxoglutarate + O2
? + succinate + CO2
show the reaction diagram
-
-
-
-
?
penicillin N + 2-oxoglutarate + O2
? + succinate + CO2
show the reaction diagram
-
-
-
-
?
penicillin N + 2-oxoglutarate + O2
succinate + CO2 + ?
show the reaction diagram
-
-
-
-
?
phenylacetyl-7-aminodeacetoxycephalosporanic acid + 2-oxoglutarate + O2
phenylacetyl-7-aminodeacetylcephalosporin + succinate + CO2
show the reaction diagram