1.14.11.27: [histone H3]-dimethyl-L-lysine36 demethylase

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For detailed information about [histone H3]-dimethyl-L-lysine36 demethylase, go to the full flat file.

Reaction

Synonyms

dKDM2, dKDM4A, dRAF, GASC1, H3-K36 demethylase, H3-K36-specific demethylase, H3K36 demethylase, H3K36me2 demethylase, H3K36me2 histone demethylase, H3K36me2-specific demethylase, histone H3 lysine 36 demethylase, histone H3 lysine 36 dimethyl�specific demethylase, histone-lysine(H3-K36) demethylase, Jhd1, JHDM1A, Jhdm1b/Kdm2b, JmjC domain histone demethylase, JmjC domain-containing histone demethylase 1, JmjC domain-containing histone demethylase 1A, JmjC domain-containing histone demethylation protein 1, JMJD2, JMJD2A, JMJD5, JMJD7, Kdm2a, KDM2B, KDM2b/JHDM1b, KDM4, KDM4A, KDM4B, Kdm4c, KDM4D, KDM8, lysine demethylase, More, Ndy1, PfJmjC1, PfSET1, scJHDM1, SET1, [histone-H3]-lysine-36 demethylase 1

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

                1.14.11.27 [histone H3]-dimethyl-L-lysine36 demethylase

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Results	in table
4	Activating Compound
1348	AA Sequence
4	Application
1	CAS Registry Number
17	Cloned(Commentary)
1	Crystallization (Commentary)
1894	Disease/ Diagnostics
2	Expression
45	General Information
8	Localization
4	Metals/Ions
2	Molecular Weight [Da]
27	Natural Substrates/ Products (Substrates)
94	Organism
113	PDB ID
1	Posttranslational Modification
24	Protein Variants
4	Purification (Commentary)
3	Reaction
30	Reference
28	Source Tissue
52	Substrates and Products (Substrate)
4	Subunits
77	Synonyms
1	Systematic Name

Expression

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Expression on EC 1.14.11.27 - [histone H3]-dimethyl-L-lysine36 demethylase

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

knockdown of Jhdm1b in primary mouse embryonic fibroblasts inhibits cell proliferation and induces cellular senescence in a pRb and p53 pathway-dependent manner. The effect of Jhdm1b on cell proliferation and cellular senescence is mediated through de-repression of p15Ink4b as loss of p15Ink4b function rescues cell proliferation defects in Jhdm1b knockdown cells

Mus musculus

Q6P1G2

700374

mRNA and protein levels of Jmjd2a are significantly increased in the neurons of mouse undergoing neuropathic pain

Mus musculus

Q8BW72

764639