1.14.11.27: [histone H3]-dimethyl-L-lysine36 demethylase

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For detailed information about [histone H3]-dimethyl-L-lysine36 demethylase, go to the full flat file.

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Synonyms

dKDM2, dKDM4A, dRAF, GASC1, H3-K36 demethylase, H3-K36-specific demethylase, H3K36 demethylase, H3K36me2 demethylase, H3K36me2 histone demethylase, H3K36me2-specific demethylase, histone H3 lysine 36 demethylase, histone H3 lysine 36 dimethyl�specific demethylase, histone-lysine(H3-K36) demethylase, Jhd1, JHDM1A, Jhdm1b/Kdm2b, JmjC domain histone demethylase, JmjC domain-containing histone demethylase 1, JmjC domain-containing histone demethylase 1A, JmjC domain-containing histone demethylation protein 1, JMJD2, JMJD2A, JMJD5, JMJD7, Kdm2a, KDM2B, KDM2b/JHDM1b, KDM4, KDM4A, KDM4B, Kdm4c, KDM4D, KDM8, lysine demethylase, More, Ndy1, PfJmjC1, PfSET1, scJHDM1, SET1, [histone-H3]-lysine-36 demethylase 1

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

                1.14.11.27 [histone H3]-dimethyl-L-lysine36 demethylase

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4	Activating Compound
1348	AA Sequence
4	Application
1	CAS Registry Number
17	Cloned(Commentary)
1	Crystallization (Commentary)
1894	Disease/ Diagnostics
2	Expression
45	General Information
8	Localization
4	Metals/Ions
2	Molecular Weight [Da]
27	Natural Substrates/ Products (Substrates)
94	Organism
113	PDB ID
1	Posttranslational Modification
24	Protein Variants
4	Purification (Commentary)
3	Reaction
30	Reference
28	Source Tissue
52	Substrates and Products (Substrate)
4	Subunits
77	Synonyms
1	Systematic Name

Natural Substrates Products

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Natural Substrates Products on EC 1.14.11.27 - [histone H3]-dimethyl-L-lysine36 demethylase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

histone H3 N6,N6,N6-trimethyl-L-lysine26 + 2-oxoglutarate + O2

histone H3 N6,N6-dimethyl-L-lysine26 + succinate + formaldehyde + CO2

Homo sapiens

O75164, O94953, Q6B0I6, Q9H3R0

-

745919

-

-

?

histone H3 N6,N6,N6-trimethyl-L-lysine36 + 2-oxoglutarate + O2

histone H3 N6,N6-dimethyl-L-lysine36 + succinate + formaldehyde + CO2

2 entries

histone H3 N6,N6,N6-trimethyl-L-lysine9 + 2-oxoglutarate + O2

histone H3 N6,N6-dimethyl-L-lysine9 + succinate + formaldehyde + CO2

Homo sapiens

O75164, O94953, Q6B0I6, Q9H3R0

-

745919

-

-

?

histone H3-N6,N6,N6-trimethyl-L-lysine36 + 2-oxoglutarate + O2

histone H3-N6,N6-dimethyl-L-lysine36 + succinate + formaldehyde + CO2

Homo sapiens

O75164, Q9H3R0

-

725450

-

-

?

histone H3-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2

histone H3-N6-methyl-L-lysine36 + succinate + formaldehyde + CO2

7 entries

protein C/EBPalpha-N6,N6-dimethyl-L-lysine + 2-oxoglutarate + O2

protein C/EBPalpha-N6-methyl-L-lysine + succinate + formaldehyde + CO2

3 entries

[histone H3]-N6,N6-dimethyl-L-lysine 36 + 2-oxoglutarate + O2

[histone H3]-N6-methyl-L-lysine 36 + succinate + formaldehyde + CO2

Mus musculus

-

-

754726

-

-

?

[histone H3]-N6,N6-dimethyl-L-lysine36 + 2 2-oxoglutarate + 2 O2

[histone H3]-L-lysine36 + 2 succinate + 2 formaldehyde + 2 CO2

4 entries

[histone H3]-N6,N6-dimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2

[histone H3]-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2

Plasmodium falciparum

-

predicted site-specificity from phylogenetic analysis

698354

-

-

?

[histone H3]-N6-methyl-L-lysine 36 + 2-oxoglutarate + O2

[histone H3]-L-lysine 36 + succinate + formaldehyde + CO2

Mus musculus

-

-

754726

-

-

?

additional information

?

-

6 entries

histone H3 N6,N6,N6-trimethyl-L-lysine36 + 2-oxoglutarate + O2

histone H3 N6,N6-dimethyl-L-lysine36 + succinate + formaldehyde + CO2

Homo sapiens

O75164, O94953, Q6B0I6, Q9H3R0

-

745919

-

-

?

histone H3 N6,N6,N6-trimethyl-L-lysine36 + 2-oxoglutarate + O2

histone H3 N6,N6-dimethyl-L-lysine36 + succinate + formaldehyde + CO2

Saccharomyces cerevisiae

P40034

-

744589

-

-

?

histone H3-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2

histone H3-N6-methyl-L-lysine36 + succinate + formaldehyde + CO2

Homo sapiens

-

-

726379, 725450

-

-

?

histone H3-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2

histone H3-N6-methyl-L-lysine36 + succinate + formaldehyde + CO2

Homo sapiens

O75164, Q9H3R0

-

725450

-

-

?

histone H3-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2

histone H3-N6-methyl-L-lysine36 + succinate + formaldehyde + CO2

Homo sapiens

-

Jhdm1a is a histone demethylase that specifically demethylates dimethylated H3K36

726260

-

-

?

histone H3-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2

histone H3-N6-methyl-L-lysine36 + succinate + formaldehyde + CO2

Homo sapiens

-

KDM2b/JHDM1b is an H3K36me2-specific demethylase

724651

-

-

?

histone H3-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2

histone H3-N6-methyl-L-lysine36 + succinate + formaldehyde + CO2

Mus musculus

-

-

724815

-

-

?

histone H3-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2

histone H3-N6-methyl-L-lysine36 + succinate + formaldehyde + CO2

Mus musculus

-

Jhdm1a is a histone demethylase that specifically demethylates dimethylated H3K36

726260

-

-

?

histone H3-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2

histone H3-N6-methyl-L-lysine36 + succinate + formaldehyde + CO2

Mus musculus C57/BL6J

-

Jhdm1a is a histone demethylase that specifically demethylates dimethylated H3K36

726260

-

-

?

protein C/EBPalpha-N6,N6-dimethyl-L-lysine + 2-oxoglutarate + O2

protein C/EBPalpha-N6-methyl-L-lysine + succinate + formaldehyde + CO2

Homo sapiens

-

Jhdm1a actively demethylates dimethylated H3K36 on the C/EBPalpha locus

726260

-

-

?

protein C/EBPalpha-N6,N6-dimethyl-L-lysine + 2-oxoglutarate + O2

protein C/EBPalpha-N6-methyl-L-lysine + succinate + formaldehyde + CO2

Mus musculus

-

-

726260

-

-

?

protein C/EBPalpha-N6,N6-dimethyl-L-lysine + 2-oxoglutarate + O2

protein C/EBPalpha-N6-methyl-L-lysine + succinate + formaldehyde + CO2

Mus musculus C57/BL6J

-

-

726260

-

-

?

[histone H3]-N6,N6-dimethyl-L-lysine36 + 2 2-oxoglutarate + 2 O2

[histone H3]-L-lysine36 + 2 succinate + 2 formaldehyde + 2 CO2

Drosophila melanogaster

-

H3K36 demethylation activity of the fly dKDM4A is dramatically stimulated upon HP1a association

701212

-

-

?

[histone H3]-N6,N6-dimethyl-L-lysine36 + 2 2-oxoglutarate + 2 O2

[histone H3]-L-lysine36 + 2 succinate + 2 formaldehyde + 2 CO2

Drosophila melanogaster

Q9VHH9

removal of histone H3 Lys36 dimethylation is coupled to histone H2A monoubiquitinylation, overview

698109

-

-

?

[histone H3]-N6,N6-dimethyl-L-lysine36 + 2 2-oxoglutarate + 2 O2

[histone H3]-L-lysine36 + 2 succinate + 2 formaldehyde + 2 CO2

Mus musculus

Q6P1G2

the effect of Jhdm1b on cell proliferation and cellular senescence is mediated through de-repression of p15Ink4b as loss of p15Ink4b function rescues cell proliferation defects in Jhdm1b knockdown cells

700374

-

-

?

[histone H3]-N6,N6-dimethyl-L-lysine36 + 2 2-oxoglutarate + 2 O2

[histone H3]-L-lysine36 + 2 succinate + 2 formaldehyde + 2 CO2

Plasmodium falciparum

-

predicted site-specificity from phylogenetic analysis

698354

-

-

?

additional information

?

-

Drosophila melanogaster

-

dynamic nature of histone methylation regulation on four of the main lysine sites of methylation on histone H3 and H4 tails, i.e. H3K4, H3K9, H3K27 and H3K36, overview. Methylation of non-histone proteins may be a general means to regulate epigenetic information

701212

-

-

?

additional information

?

-

Mus musculus

Q6P1G2

substrate specificity of Jhdm1b in vivo using HEK293 cells overexpressing the enzyme, overview

700374

-

-

?

additional information

?

-

Mus musculus

-

substrate specificity of Jhdm1b in vivo using HEK293 cells overexpressing the enzyme, overview

700374

-

-

?

additional information

?

-

Plasmodium falciparum

-

histone methyl-lysine marks display dynamic changes during the parasite asexual erythrocytic cycle, suggesting that they constitute an important epigenetic mechanism of gene regulation in malaria parasites

698354

-

-

?

additional information

?

-

Rattus norvegicus

-

Ndy1 is a physiological inhibitor of senescence in dividing cells and inhibition of senescence depends on histone H3 demethylation

689797

-

-

?

additional information

?

-

Saccharomyces cerevisiae

P40034

enzyme Jhd1 is also active on H3K9 methyl groups

744589

-

-

?