1.14.11.27: [histone H3]-dimethyl-L-lysine36 demethylase

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For detailed information about [histone H3]-dimethyl-L-lysine36 demethylase, go to the full flat file.

Word Map on EC 1.14.11.27

1.14.11.27

demethylases

chromatin

demethylation

h3k9me3

trimethylation

jumonji

tumorigenesis

methyltransferases

lysine-specific

heterochromatin

tri-methylated

tudor

chromatin-modifying

jmjd1a

jmjc-domain-containing

setdb1

Reaction

a [histone H3]-N6,N6-dimethyl-L-lysine36

+ 2 2-oxoglutarate + 2 O2 =

+ 2 succinate + 2 formaldehyde + 2 CO2

Synonyms

dKDM2, dKDM4A, dRAF, GASC1, H3-K36 demethylase, H3-K36-specific demethylase, H3K36 demethylase, H3K36me2 demethylase, H3K36me2 histone demethylase, H3K36me2-specific demethylase, histone H3 lysine 36 demethylase, histone H3 lysine 36 dimethyl�specific demethylase, histone-lysine(H3-K36) demethylase, Jhd1, JHDM1A, Jhdm1b/Kdm2b, JmjC domain histone demethylase, JmjC domain-containing histone demethylase 1, JmjC domain-containing histone demethylase 1A, JmjC domain-containing histone demethylation protein 1, JMJD2, JMJD2A, JMJD5, JMJD7, Kdm2a, KDM2B, KDM2b/JHDM1b, KDM4, KDM4A, KDM4B, Kdm4c, KDM4D, KDM8, lysine demethylase, More, Ndy1, PfJmjC1, PfSET1, scJHDM1, SET1, [histone-H3]-lysine-36 demethylase 1

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

1.14.11.27 [histone H3]-dimethyl-L-lysine36 demethylase

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Results	in table
4	Activating Compound
1348	AA Sequence
4	Application
1	CAS Registry Number
17	Cloned(Commentary)
1	Crystallization (Commentary)
1894	Disease/ Diagnostics
2	Expression
45	General Information
8	Localization
4	Metals/Ions
2	Molecular Weight [Da]
27	Natural Substrates/ Products (Substrates)
94	Organism
113	PDB ID
1	Posttranslational Modification
24	Protein Variants
4	Purification (Commentary)
3	Reaction
30	Reference
28	Source Tissue
52	Substrates and Products (Substrate)
4	Subunits
77	Synonyms
1	Systematic Name

Source Tissue

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Source Tissue on EC 1.14.11.27 - [histone H3]-dimethyl-L-lysine36 demethylase

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breast cancer cell

Homo sapiens

O75164, O94953, Q6B0I6, Q9H3R0

esophageal squamous cell carcinoma cell

Homo sapiens

O75164, O94953, Q6B0I6, Q9H3R0

745919

fibroblast

2 entries

gastric cancer cell line

Homo sapiens

O75164, O94953, Q6B0I6, Q9H3R0

high expression level of KDM2b/JHDM1b

O75164, O94953, Q6B0I6, Q9H3R0

additional information

Sus scrofa

the mRNA expression of porcine JHDM1A is significantly higher in the middle at 65 days and later at 90 days period's embryo skeletal muscle than that of 33 days, and showed a ubiquitously expression but with the highest abundance in kidney, lung and liver of an adult pig

712996