1.14.11.28: proline 3-hydroxylase
This is an abbreviated version!
For detailed information about proline 3-hydroxylase, go to the full flat file.
Word Map on EC 1.14.11.28
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1.14.11.28
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2-oxoglutarate-dependent
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leprel1
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early-onset
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ferrous
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myopia
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exome
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autosomal-recessive
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choroid
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neovascularization
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3-hydroxyproline
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regio
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pharmacology
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4-hydroxylase
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cataract
- 1.14.11.28
-
2-oxoglutarate-dependent
- leprel1
-
early-onset
-
ferrous
- myopia
-
exome
-
autosomal-recessive
-
choroid
-
neovascularization
-
3-hydroxyproline
-
regio
- pharmacology
-
4-hydroxylase
-
cataract
Reaction
Synonyms
C-P3H, C-P4H, collagen prolyl hydroxylases 3, collagen prolyl hydroxylases 4, L-proline-3-hydroxylase, Leprel1, Leprel2, P-3-H, P3H, P3H1, P3H2, P3H3, proline 3-hydroxylase, proline 3-hydroxylase type I, proline 3-hydroxylase type II, prolyl 3-hydrolase, prolyl 3-hydroxylase 2
ECTree
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Reference on EC 1.14.11.28 - proline 3-hydroxylase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Mori, H.; Shibasaki, T.; Uozaki, Y.; Ochiai, K.; Ozaki, A.
Detection of novel proline 3-hydroxylase activities in Streptomyces and Bacillus spp. by regio- and stereospecific hydroxylation of L-proline
Appl. Environ. Microbiol.
62
1903-1907
1996
Bacillus sp. (in: Bacteria), Streptomyces sp., Streptomyces canus, Bacillus sp. (in: Bacteria) TH2, Bacillus sp. (in: Bacteria) TH3, Streptomyces sp. TH1
Shibasaki, T.; Mori, H.; Ozaki, A.
Cloning of an isozyme of proline 3-hydroxylase and its purification from recombinant Escherichia coli
Biotechnol. Lett.
22
1967-1973
2000
Streptomyces sp., Streptomyces sp. TH1
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Clifton, I.J.; Hsueh, L.C.; Baldwin, J.E.; Harlos, K.; Schofield, C.J.
Structure of proline 3-hydroxylase. Evolution of the family of 2-oxoglutarate dependent oxygenases
Eur. J. Biochem.
268
6625-6636
2001
Streptomyces sp., Streptomyces sp. TH1
Mori, H.; Shibasaki, T.; Yano, K.; Ozaki, A.
Purification and cloning of a proline 3-hydroxylase, a novel enzyme which hydroxylates free L-proline to cis-3-hydroxy-L-proline
J. Bacteriol.
179
5677-5683
1997
Streptomyces sp., Streptomyces sp. TH1
Vranka, J.A.; Sakai, L.Y.; Bachinger, H.P.
Prolyl 3-hydroxylase 1, enzyme characterization and identification of a novel family of enzymes
J. Biol. Chem.
279
23615-23621
2004
Gallus gallus
Shibasaki, T.; Sakurai, W.; Hasegawa, A.; Uosaki, Y.; Mori, H.; Yoshida, M.; Ozaki, A.
Substrate selectivities of proline hydroxylases
Tetrahedron Lett.
40
5227-5230
1999
Streptomyces sp., Streptomyces sp. TH1
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Shah, R.; Smith, P.; Purdie, C.; Quinlan, P.; Baker, L.; Aman, P.; Thompson, A.M.; Crook, T.
The prolyl 3-hydroxylases P3H2 and P3H3 are novel targets for epigenetic silencing in breast cancer
Br. J. Cancer
100
1687-1696
2009
Homo sapiens (Q32P28), Homo sapiens (Q8IVL6)
Johnston, R.; Chu, L.; Liu, M.; Goldberg, S.; Goswami, A.; Patel, R.
Hydroxylation of L-proline to cis-3-hydroxy-L-proline by recombinant Escherichia coli expressing a synthetic L-proline-3-hydroxylase gene
Enzyme Microb. Technol.
45
484-490
2009
Streptomyces sp., Streptomyces sp. TH1
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Mordechai, S.; Gradstein, L.; Pasanen, A.; Ofir, R.; El Amour, K.; Levy, J.; Belfair, N.; Lifshitz, T.; Joshua, S.; Narkis, G.; Elbedour, K.; Myllyharju, J.; Birk, O.S.
High myopia caused by a mutation in LEPREL1, encoding prolyl 3-hydroxylase 2
Am. J. Hum. Genet.
89
438-445
2011
Homo sapiens
Hatzimichael, E.; Lo Nigro, C.; Lattanzio, L.; Syed, N.; Shah, R.; Dasoula, A.; Janczar, K.; Vivenza, D.; Monteverde, M.; Merlano, M.; Papoudou-Bai, A.; Bai, M.; Schmid, P.; Stebbing, J.; Bower, M.; Dyer, M.J.; Karran, L.E.; ElguetaKarstegl, C.; Farrell, P.J.; Thompson, A.; Briasoulis, E.; Crook, T.
The collagen prolyl hydroxylases are novel transcriptionally silenced genes in lymphoma
Br. J. Cancer
107
1423-1432
2012
Homo sapiens
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