1.14.11.28: proline 3-hydroxylase
This is an abbreviated version!
For detailed information about proline 3-hydroxylase, go to the full flat file.
Word Map on EC 1.14.11.28
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1.14.11.28
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2-oxoglutarate-dependent
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leprel1
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early-onset
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ferrous
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myopia
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exome
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autosomal-recessive
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choroid
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neovascularization
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3-hydroxyproline
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regio
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pharmacology
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4-hydroxylase
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cataract
- 1.14.11.28
-
2-oxoglutarate-dependent
- leprel1
-
early-onset
-
ferrous
- myopia
-
exome
-
autosomal-recessive
-
choroid
-
neovascularization
-
3-hydroxyproline
-
regio
- pharmacology
-
4-hydroxylase
-
cataract
Reaction
Synonyms
C-P3H, C-P4H, collagen prolyl hydroxylases 3, collagen prolyl hydroxylases 4, L-proline-3-hydroxylase, Leprel1, Leprel2, P-3-H, P3H, P3H1, P3H2, P3H3, proline 3-hydroxylase, proline 3-hydroxylase type I, proline 3-hydroxylase type II, prolyl 3-hydrolase, prolyl 3-hydroxylase 2
ECTree
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Systematic Name
Systematic Name on EC 1.14.11.28 - proline 3-hydroxylase
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L-proline,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)
Requires iron(II) for activity. Unlike the proline hydroxylases involved in collagen biosynthesis [EC 1.14.11.2 (procollagen-proline dioxygenase) and EC 1.14.11.7 (procollagen-proline 3-dioxygenase)], this enzyme does not require ascorbate for activity although it does increase the activity of the enzyme [2]. The enzyme is specific for L-proline as D-proline, trans-4-hydroxy-L-proline, cis-4-hydroxy-L-proline and 3,4-dehydro-DL-proline are not substrates [2].