1.14.11.30: hypoxia-inducible factor-asparagine dioxygenase

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For detailed information about hypoxia-inducible factor-asparagine dioxygenase, go to the full flat file.

Word Map on EC 1.14.11.30

1.14.11.30

prolyl

hydroxylases

transactivation

oxygen-dependent

ankyrin

normoxia

hippel-lindau

oxygen-sensing

hif-alpha

prolyl-hydroxylase

fih-mediated

2og-dependent

hypoxia-sensitive

dimethyloxalylglycine

2-oxoglutarate-dependent

medicine

drug development

Reaction

hypoxia-inducible factor-(3S)-3-hydroxy-L-asparagine

Synonyms

asparaginyl hydroxylase, asparaginyl-hydroxylase, factor inhibiting HIF, factor inhibiting HIF-1, factor inhibiting hypoxia inducible factor-1alpha, factor-inhibiting HIF, factor-inhibiting hypoxia inducible factor, factor-inhibiting hypoxia-inducible factor, FIH, FIH hydroxylase, HIF asparagine hydroxylase, HIF asparaginyl hydroxylase, HIF hydroxylase, HIF1AN, hypoxia-inducible factor 1-alpha inhibitor, hypoxia-inducible factor asparagine hydroxylase

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

1.14.11.30 hypoxia-inducible factor-asparagine dioxygenase

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Results	in table
5	Activating Compound
11	AA Sequence
3	Application
5	Cloned(Commentary)
2	Crystallization (Commentary)
57	Disease/ Diagnostics
1	Expression
19	General Information
13	IC50 Value
29	Inhibitors
6	kcat/KM [mM/s]
8	Ki Value [mM]
15	KM Value [mM]
9	Metals/Ions
15	Natural Substrates/ Products (Substrates)
18	Organism
29	PDB ID
4	pH Optimum
5	Protein Variants
5	Purification (Commentary)
1	Reaction
18	Reference
16	Source Tissue
37	Substrates and Products (Substrate)
1	Subunits
39	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
7	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 1.14.11.30 - hypoxia-inducible factor-asparagine dioxygenase

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ascorbate

3 entries

ferritin heavy chain

Homo sapiens

Q9NWT6

i.e. FTH1, directly activates FIH to hydroxylate HIF-1alpha to ensure its normoxic inactivation. In iron-rich conditions, the transcriptional activity of HIF-1alpha is also inhibited due to forceful induction of FTH1

764068