1.14.11.32: codeine 3-O-demethylase
This is an abbreviated version!
For detailed information about codeine 3-O-demethylase, go to the full flat file.
Word Map on EC 1.14.11.32
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1.14.11.32
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thebaine
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morphine
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poppy
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opium
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papaver
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somniferum
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benzylisoquinoline
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o-demethylation
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codeinone
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morphinans
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virus-induced
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analgesics
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dioxygenases
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acinetobacter
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narcotic
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opiate
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salutaridinol
- 1.14.11.32
- thebaine
- morphine
- poppy
-
opium
-
papaver
- somniferum
-
benzylisoquinoline
-
o-demethylation
- codeinone
-
morphinans
-
virus-induced
-
analgesics
- dioxygenases
- acinetobacter
-
narcotic
-
opiate
- salutaridinol
Reaction
Synonyms
codeine O-demethylase, codeine-O-demethylase, CODM
ECTree
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Engineering
Engineering on EC 1.14.11.32 - codeine 3-O-demethylase
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E338G/I340L/L341V/K342E
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site-directed mutagenesis, the mutant exhibits demethylase activity exclusively toward codeine, not also toward thebaine like the wild-type enzyme
R334S/R336S
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site-directed mutagenesis, the mutant retains O-demethylase activity toward either thebaine or codeine like the wild-type enzyme
R334S/R336T
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site-directed mutagenesis, the mutant retains O-demethylase activity toward either thebaine or codeine like the wild-type enzyme
S149M/L151F/S152T
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site-directed mutagenesis, the mutant is expressed at low levels, perhaps due to improper folding