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1.14.11.33: DNA oxidative demethylase

This is an abbreviated version!
For detailed information about DNA oxidative demethylase, go to the full flat file.

Word Map on EC 1.14.11.33

Reaction

DNA-base-CH3
+
2-oxoglutarate
 +
O2
=
DNA-base
 +
formaldehyde
 +
succinate
 +
CO2

Synonyms

1-methyladenine-DNA dioxygenase, ABH1, ABH2, ABH3, AlkB, AlkB homolog 1, ALKBH2, ALKBH3, ALKBH8, alkylated DNA repair protein, alpha-ketoglutarate-dependent dioxygenase ABH1, FTO

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.33 DNA oxidative demethylase

KCat KM Value

KCat KM Value on EC 1.14.11.33 - DNA oxidative demethylase

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kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1.7
1-methyl-ATP
-
at 37°C, pH not specified in the publication
35
1-methyl-dAMP
-
at 37°C, pH not specified in the publication
11.7
1-methyl-dATP
-
at 37°C, pH not specified in the publication
3.3
2'-deoxy-1-methyl-adenosine 3'-phosphate
-
at 37°C, pH not specified in the publication
43
d(Tpm1ApT)
-
at 37°C, pH not specified in the publication
61.8
DNA-N1-methyladenine
wild type enzyme, pH and temperature not specified in the publication
-
8
double-stranded DNA-1-methyladenine
-
at 25°C, pH not specified in the publication
-
5.8
double-stranded DNA-3-methylcytosine
-
at 25°C, pH not specified in the publication
-
143
poly(dm1A)
-
at 37°C, pH not specified in the publication
-
11.3
single-stranded DNA-1-methyladenine
-
at 25°C, pH not specified in the publication
-
10.8
single-stranded DNA-3-methylcytosine
-
at 25°C, pH not specified in the publication
-