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1.14.11.53: mRNA N6-methyladenine demethylase

This is an abbreviated version!
For detailed information about mRNA N6-methyladenine demethylase, go to the full flat file.

Word Map on EC 1.14.11.53

Reaction

N6-methyladenine in mRNA
+
2-oxoglutarate
+
O2
=
adenine in mRNA
+
formaldehyde
+
succinate
+
CO2

Synonyms

AlkB homolog 5, ALKBH10B, ALKBH5, ALKBH5 demethylase, ALKBH9B, alkylation repair homolog protein 5, fat mass and obesity-associated enzyme, fat mass and obesity-associated protein, FTO, m6A mRNA demethylase, m6A RNA demethylase, m6A-RNA demethylase, N6-methyladenosine demethylase, RNA N6-methyladenine demethylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.53 mRNA N6-methyladenine demethylase

Expression

Expression on EC 1.14.11.53 - mRNA N6-methyladenine demethylase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
ALKBH5 is upregulated under hypoxia
ALKBH5 mRNA and protein expression are upregulated during osteoblast differentiation
ALKBH5 mRNA levels are significantly increased under hypoxic conditions by greater than 1.6fold in SUM-159 and MDA-MB-435 cells and greater than 2fold in MDA-MB-231 and MCF-7 cells
-
expression of ALKBH10B is increased in response to abscisic acid, osmotic, and salt stress