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1.14.11.53: mRNA N6-methyladenine demethylase

This is an abbreviated version!
For detailed information about mRNA N6-methyladenine demethylase, go to the full flat file.

Word Map on EC 1.14.11.53

Reaction

N6-methyladenine in mRNA
+
2-oxoglutarate
+
O2
=
adenine in mRNA
+
formaldehyde
+
succinate
+
CO2

Synonyms

AlkB homolog 5, ALKBH10B, ALKBH5, ALKBH5 demethylase, ALKBH9B, alkylation repair homolog protein 5, fat mass and obesity-associated enzyme, fat mass and obesity-associated protein, FTO, m6A mRNA demethylase, m6A RNA demethylase, m6A-RNA demethylase, N6-methyladenosine demethylase, RNA N6-methyladenine demethylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.53 mRNA N6-methyladenine demethylase

KM Value

KM Value on EC 1.14.11.53 - mRNA N6-methyladenine demethylase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0025
2-oxoglutarate
-
at pH 8.0 and 37°C
0.000192
5'-UACACUCGAUCUGG(m6A)CUAAAGCUGCUC-3'-biotin
-
at pH 8.0 and 37°C
-
2.583
CCCC(m6A)CCCCCCCCC
-
at pH 7.4 and 37°C
2.251
GA(m6A)CA
-
at pH 7.4 and 37°C
1.755
GCGG(m6A)CUCCAGAUG
-
at pH 7.4 and 37°C
2.334
GG(m6A)CU
-
at pH 7.4 and 37°C
0.00095 - 0.00192
N3-methylthymine in single-stranded DNA
-
0.00208 - 0.00851
N3-methyluracil in single-stranded mRNA
-
0.00166
N6-methyladenine in mRNA
-
pH and temperature not specified in the publication
-