1.14.11.7: procollagen-proline 3-dioxygenase
This is an abbreviated version!
For detailed information about procollagen-proline 3-dioxygenase, go to the full flat file.
Word Map on EC 1.14.11.7
-
1.14.11.7
-
hypoxia-inducible
-
fibrosis
-
hydroxyproline
-
factor-1
-
endothelial
-
hydroxylases
-
hif-1alpha
-
erythropoietin
-
anemia
-
domain-containing
-
lysyl
-
ascorbate
-
oxygen-dependent
-
normoxic
-
hippel-lindau
-
4-hydroxylase
-
imperfecta
-
osteogenesis
-
dmog
-
dimethyloxalylglycine
-
bleomycin
-
factor-1alpha
-
oxygen-sensing
-
angiogenic
-
2-oxoglutarate-dependent
-
hypoxia-responsive
-
chick-embryo
-
hif-dependent
-
hydroxylysine
-
hif-prolyl
-
roxadustat
-
o2-dependent
-
bleomycin-induced
-
ppib
-
polycythemia
-
fkbp10
-
intratracheal
-
3-hydroxylation
-
3,4-dihydroxybenzoic
-
prolyl-hydroxylase
-
hepcidin
-
oxygen-sensitive
-
1.14.11.2
-
hydroxyproline-rich
-
col1a2
-
serpinh1
-
lindau
-
l-mimosine
-
erythropoiesis-stimulating
- 1.14.11.7
-
hypoxia-inducible
- fibrosis
- hydroxyproline
- factor-1
- endothelial
- hydroxylases
- hif-1alpha
- erythropoietin
- anemia
-
domain-containing
-
lysyl
- ascorbate
-
oxygen-dependent
-
normoxic
-
hippel-lindau
-
4-hydroxylase
- imperfecta
-
osteogenesis
- dmog
- dimethyloxalylglycine
- bleomycin
- factor-1alpha
-
oxygen-sensing
-
angiogenic
-
2-oxoglutarate-dependent
-
hypoxia-responsive
-
chick-embryo
-
hif-dependent
- hydroxylysine
-
hif-prolyl
-
roxadustat
-
o2-dependent
-
bleomycin-induced
- ppib
- polycythemia
- fkbp10
-
intratracheal
-
3-hydroxylation
-
3,4-dihydroxybenzoic
-
prolyl-hydroxylase
- hepcidin
-
oxygen-sensitive
-
1.14.11.2
-
hydroxyproline-rich
-
col1a2
-
serpinh1
-
lindau
- l-mimosine
-
erythropoiesis-stimulating
Reaction
Synonyms
LEPRE1, Leprel1, Leprel2, More, oxygenase, protocollagen proline 3-di-, P3H1, P3H2, P3H3, PHD3, proline,2-oxoglutarate 3-dioxygenase, prolyl 3-hydroxylase, prolyl 3-hydroxylase 1, prolyl 3-hydroxylase 2, prolyl 3-hydroxylase-2, prolyl hydroxylase, prolyl-4-hydroxyprolyl-glycyl-peptide, 2-oxoglutarate: oxygen oxidoreductase, 3-hydroxylating, protocollagen proline 3-hydroxylase
ECTree
Advanced search results
Natural Substrates Products
Natural Substrates Products on EC 1.14.11.7 - procollagen-proline 3-dioxygenase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REACTION DIAGRAM
L-proline-[collagen] + O2
3-hydroxy-L-proline-[collagen]
-
-
-
?
procollagen L-proline + 2-oxoglutarate + O2
procollagen trans-3-hydroxy-L-proline + succinate + CO2
-
P3H1 catalyzes the 3-hydroxylation of specific proline residues in procollagen I
-
-
?
[procollagen]-L-proline + 2-oxoglutarate + O2
[procollagen]-trans-3-hydroxy-L-proline + succinate + CO2
procollagen trans-3-hydroxy-L-proline + succinate + CO2
-
the enzyme catalyzes the synthesis of 3-hydroxyproline in collagen by the hydroxylation of prolyl residues
-
-
?
procollagen + 2-oxoglutarate + O2
procollagen trans-3-hydroxy-L-proline + succinate + CO2
-
the enzyme catalyzes the synthesis of 3-hydroxyproline in collagen by the hydroxylation of prolyl residues
-
-
?
[procollagen]-trans-3-hydroxy-L-proline + succinate + CO2
-
-
-
?
[procollagen]-L-proline + 2-oxoglutarate + O2
[procollagen]-trans-3-hydroxy-L-proline + succinate + CO2
-
-
-
?
[procollagen]-L-proline + 2-oxoglutarate + O2
[procollagen]-trans-3-hydroxy-L-proline + succinate + CO2
prolyl 3-hydroxylation in lens capsule, prolyl 3-hydroxylation at Pro602 from alpha1(IV) and Pro197 from alpha2(IV). Pro707 site in alpha1(I) is a tissue-specific substrate unique to P3h2
-
-
?
[procollagen]-L-proline + 2-oxoglutarate + O2
[procollagen]-trans-3-hydroxy-L-proline + succinate + CO2
Residue alpha1(I) K930 is 98% hydroxylated and non-glycosylated in both genotypes and alpha1(I)K87 is 92% hydroxylated in wild-type and 93% in Lepre1H662A/H662A
-
-
?
[procollagen]-L-proline + 2-oxoglutarate + O2
[procollagen]-trans-3-hydroxy-L-proline + succinate + CO2
type IV collagen
-
-
?
?
-
the P3H1-CRTAP-Cyp B complex does not stabilize the collagen triple helix, but does inhibit collgane fibril formation, overview
-
-
?
additional information
?
-
isoform P3H2 is responsible for the hydroxylation of collagen IV
-
-
?
additional information
?
-
isoform P3H2 is responsible for the hydroxylation of collagen IV
-
-
?
additional information
?
-
-
isoform P3H2 is responsible for the hydroxylation of collagen IV
-
-
?
additional information
?
-
-
the collagen prolyl 3-hydroxylation complex, comprised by cyclophilin B (PPIB), CRTAP and P3H1, catalyzes a specific posttranslational modification of types I, II, and V collagen, and may act as a general chaperone. Collagen 3-hydroxylation complex function, overview
-
-
?
additional information
?
-
type IV collagen contains more prolyl 3-hydroxylation sites than any other collagen types
-
-
?
additional information
?
-
-
type IV collagen contains more prolyl 3-hydroxylation sites than any other collagen types
-
-
?