1.14.11.8: trimethyllysine dioxygenase

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For detailed information about trimethyllysine dioxygenase, go to the full flat file.

Reaction

Synonyms

6-N-trimethyllysine dioxygenase, epsilon-N-trimethyllysine hydroxylase, epsilon-trimethyllysine 2-oxoglutarate dioxygenase, eta-N-trimethyllysine hydroxylase, Nepsilon-trimethyllysine hydroxylase, oxygenase, trimethyllysine di-, TML dioxygenase, TML hydroxylase, TML-alpha-ketoglutarate dioxygenase, TMLD, TMLH, TMLH-a, TMLH-b, trimethyllysine alpha-ketoglutarate dioxygenase, trimethyllysine hydroxylase

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

                1.14.11.8 trimethyllysine dioxygenase

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Results	in table
9	Activating Compound
1739	AA Sequence
1	CAS Registry Number
7	Cloned(Commentary)
6	Cofactor
1	Expression
14	General Information
14	Inhibitors
18	KM Value [mM]
13	Localization
17	Metals/Ions
5	Molecular Weight [Da]
11	Natural Substrates/ Products (Substrates)
22	Organism
5	Pathway
7	pH Optimum
1	Posttranslational Modification
8	Protein Variants
5	Purification (Commentary)
1	Reaction
1	Reaction Type
22	Reference
32	Source Tissue
2	Specific Activity [micromol/min/mg]
2	Storage Stability
34	Substrates and Products (Substrate)
3	Subunits
42	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
1	Temperature Stability [°C]

Expression

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Expression on EC 1.14.11.8 - trimethyllysine dioxygenase

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

pigs fed a high-lysine diet have lower concentrations of free and total carnitine in plasma, liver, kidney and skeletal muscle than control pigs, and have an increased concentration of trimethyllysine, TML, a reduced mRNA abundance of TML dioxygenase and reduced concentrations of gamma-butyrobetaine in muscle, indicating that the conversion of trimethyllysine into gamma-butyrobetaine in muscle is impaired

Sus scrofa

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