1.14.12.17: nitric oxide dioxygenase
This is an abbreviated version!
For detailed information about nitric oxide dioxygenase, go to the full flat file.
Word Map on EC 1.14.12.17
-
1.14.12.17
-
heme
-
neuroglobin
-
myoglobin
-
nitrosative
-
nitrite
-
ferric
-
ferrous
-
hexacoordinate
-
dioxygenation
-
oxygen-limited
-
monoxide
-
microaerobic
-
stellate
-
oxygen-binding
-
hemoprotein
-
pentacoordinate
-
heme-containing
-
no-sensitive
-
peroxidase-like
-
o2-dependent
-
nonsymbiotic
-
s-nitrosoglutathione
-
co-difference
-
eutrophus
-
methemoglobin
-
analysis
- 1.14.12.17
- heme
-
neuroglobin
- myoglobin
-
nitrosative
- nitrite
-
ferric
-
ferrous
-
hexacoordinate
-
dioxygenation
-
oxygen-limited
- monoxide
-
microaerobic
-
stellate
-
oxygen-binding
- hemoprotein
-
pentacoordinate
-
heme-containing
-
no-sensitive
-
peroxidase-like
-
o2-dependent
-
nonsymbiotic
- s-nitrosoglutathione
-
co-difference
- eutrophus
- methemoglobin
- analysis
Reaction
2 nitric oxide
+
2 O2
+
Synonyms
barley hemoglobin, Cygb, cytoglobin, FHb1, flavoHb, flavohemoglobin, HbN, hemoglobin N, nitric oxide dioxygenase, nitric-oxide dioxygenase, NO degrading dioxygenase, NO dioxygenase, NOD, SHP, sphaeroides haem protein, type I flavohemoglobin, VHb, Vitreoscilla hemoglobin
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Reference on EC 1.14.12.17 - nitric oxide dioxygenase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Gardner, P.R.; Gardner, A.M.; Martin, L.A.; Salzman, A.L.
Nitric oxide dioxygenase: an enzymic function for flavohemoglobin
Proc. Natl. Acad. Sci. USA
95
10378-10383
1998
Escherichia coli
Gardner, P.R.; Costantino, G.; Salzman, A.L.
Constitutive and adaptive detoxification of nitric oxide in Escherichia coli. Role of nitric-oxide dioxygenase in the protection of aconitase
J. Biol. Chem.
273
26528-26533
1998
Escherichia coli
Gardner, A.M.; Martin, L.A.; Gardner, P.R.; Dou, Y.; Olson, J.S.
Steady-state and transient kinetics of Escherichia coli nitric-oxide dioxygenase (flavohemoglobin). The B10 tyrosine hydroxyl is essential for dioxygen binding and catalysis
J. Biol. Chem.
275
12581-12589
2000
Escherichia coli
Helmick, R.A.; Fletcher, A.E.; Gardner, A.M.; Gessner, C.R.; Hvitved, A.N.; Gustin, M.C.; Gardner, P.R.
Imidazole antibiotics inhibit the nitric oxide dioxygenase function of microbial flavohemoglobin
Antimicrob. Agents Chemother.
49
1837-1843
2005
Candida albicans, Escherichia coli, Saccharomyces cerevisiae
Schmidt, K.; Mayer, B.
Consumption of nitric oxide by endothelial cells: evidence for the involvement of a NAD(P)H-, flavin- and heme-dependent dioxygenase reaction
FEBS Lett.
577
199-204
2004
Sus scrofa
Hallstrom, C.K.; Gardner, A.M.; Gardner, P.R.
Nitric oxide metabolism in mammalian cells: substrate and inhibitor profiles of a NADPH-cytochrome P450 oxidoreductase-coupled microsomal nitric oxide dioxygenase
Free Radic. Biol. Med.
37
216-228
2004
Homo sapiens
Igamberdiev, A.U.; Seregelyes, C.; Manac'h, N.; Hill, R.D.
NADH-dependent metabolism of nitric oxide in alfalfa root cultures expressing barley hemoglobin
Planta
219
95-102
2004
Hordeum vulgare
Lama, A.; Pawaria, S.; Dikshit, K.L.
Oxygen binding and NO scavenging properties of truncated hemoglobin, HbN, of Mycobacterium smegmatis
FEBS Lett.
580
4031-4041
2006
Mycolicibacterium smegmatis
Gardner, P.R.; Gardner, A.M.; Brashear, W.T.; Suzuki, T.; Hvitved, A.N.; Setchell, K.D.; Olson, J.S.
Hemoglobins dioxygenate nitric oxide with high fidelity
J. Inorg. Biochem.
100
542-550
2006
Escherichia coli
Gardner, P.R.
Nitric oxide dioxygenase function and mechanism of flavohemoglobin, hemoglobin, myoglobin and their associated reductases
J. Inorg. Biochem.
99
247-266
2005
Cupriavidus necator, Bacillus subtilis, Saccharomyces cerevisiae, Deinococcus radiodurans, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella enterica subsp. enterica serovar Typhimurium
Mishina, T.E.; Lamb, C.; Zeier, J.
Expression of a nitric oxide degrading enzyme induces a senescence programme in Arabidopsis
Plant Cell Environ.
30
39-52
2007
Arabidopsis thaliana
Mowat, C.G.; Gazur, B.; Campbell, L.P.; Chapman, S.K.
Flavin-containing heme enzymes
Arch. Biochem. Biophys.
493
37-52
2010
Saccharomyces cerevisiae, Escherichia coli (P24232), Cupriavidus necator (P39662)
Li, B.R.; Anderson, J.L.; Mowat, C.G.; Miles, C.S.; Reid, G.A.; Chapman, S.K.
Rhodobacter sphaeroides haem protein: a novel cytochrome with nitric oxide dioxygenase activity
Biochem. Soc. Trans.
36
992-995
2008
Cereibacter sphaeroides
Kaur, R.; Ahuja, S.; Anand, A.; Singh, B.; Stark, B.C.; Webster, D.A.; Dikshit, K.L.
Functional implications of the proximal site hydrogen bonding network in Vitreoscilla hemoglobin (VHb): role of Tyr95 (G5) and Tyr126 (H12)
FEBS Lett.
582
3494-3500
2008
Vitreoscilla
Schopfer, M.P.; Mondal, B.; Lee, D.H.; Sarjeant, A.A.; Karlin, K.D.
Heme/O2/*NO nitric oxide dioxygenase (NOD) reactivity: phenolic nitration via a putative heme-peroxynitrite intermediate
J. Am. Chem. Soc.
131
11304-11305
2009
Escherichia coli, Mammalia
Gardner, A.M.; Cook, M.R.; Gardner, P.R.
Nitric-oxide dioxygenase function of human cytoglobin with cellular reductants and in rat hepatocytes
J. Biol. Chem.
285
23850-23857
2010
Homo sapiens
Forrester, M.T.; Eyler, C.E.; Rich, J.N.
Bacterial flavohemoglobin: a molecular tool to probe mammalian nitric oxide biology
Biotechniques
50
41-45
2011
Escherichia coli
Yokoyama, A.; Han, J.E.; Cho, J.; Kubo, M.; Ogura, T.; Siegler, M.A.; Karlin, K.D.; Nam, W.
Chromium(IV)-peroxo complex formation and its nitric oxide dioxygenase reactivity
J. Am. Chem. Soc.
134
15269-15272
2012
synthetic construct
Thakur, N.; Gupta, S.; Hade, M.D.; Dikshit, K.L.
Type I flavohemoglobin of Mycobacterium smegmatis is a functional nitric oxide dioxygenase
IUBMB Life
66
396-404
2014
Mycolicibacterium smegmatis, Mycolicibacterium smegmatis mc(2)155 / ATCC 700084
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