1.14.12.22: carbazole 1,9a-dioxygenase

This is an abbreviated version!
For detailed information about carbazole 1,9a-dioxygenase, go to the full flat file.

Word Map on EC 1.14.12.22

1.14.12.22

ferredoxin

rieske

resinovorans

carac

carbazole-degradation

dibenzo-p-dioxins

dibenzofurans

fluorene

aromaticivorans

nocardioides

dianhydride

dibenzothiophene

polyimide

janthinobacterium

stipes

degradation

Reaction

Synonyms

CarAa, CarAc, carbazole dioxygenase, CARDO, CARDO-F, CARDO-R

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.12 With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor

1.14.12.22 carbazole 1,9a-dioxygenase

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Results	in table
1	Activating Compound
45	AA Sequence
2	Application
1	CAS Registry Number
17	Cloned(Commentary)
20	Cofactor
17	Crystallization (Commentary)
2	Expression
5	kcat/KM [mM/s]
5	KM Value [mM]
4	Metals/Ions
12	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
81	Organism
4	Pathway
76	PDB ID
2	pH Optimum
23	Protein Variants
7	Purification (Commentary)
2	Reaction
49	Reference
7	Storage Stability
98	Substrates and Products (Substrate)
13	Subunits
13	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
3	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.14.12.22 - carbazole 1,9a-dioxygenase

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9H-carbazole,NAD(P)H:oxygen oxidoreductase (2,3-hydroxylating)

This enzyme catalyses the first reaction in the pathway of carbazole degradation. The enzyme attacks at the 1 and 9a positions of carbazole, resulting in the formation of a highly unstable hemiaminal intermediate that undergoes a spontaneous cleavage and rearomatization, resulting in 2'-aminobiphenyl-2,3-diol. In most bacteria the enzyme is a complex composed of a terminal oxygenase, a ferredoxin, and a ferredoxin reductase. The terminal oxygenase component contains a nonheme iron centre and a Rieske [2Fe-2S] iron-sulfur cluster.