1.14.13.113: FAD-dependent urate hydroxylase
This is an abbreviated version!
For detailed information about FAD-dependent urate hydroxylase, go to the full flat file.
Reaction
Synonyms
FAD-dependent urate oxidase, flavin adenine dinucleotide-dependent urate oxidase, HpxO, HpxO enzyme, HpyO, urate hydroxylase, XCC0279
ECTree
1.14.13.113 FAD-dependent urate hydroxylaseAdvanced search results
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Substrates Products on EC 1.14.13.113 - FAD-dependent urate hydroxylase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
urate + NADPH + H+ + O2
5-hydroxyisourate + NADP+ + H2O
the enzyme is slightly more efficient (about 2.6times) with NADPH than NADH
-
-
?
additional information
?
-
-
urate oxidase can catalyze the slow conversion of NADPH to NADP+ in the absence of urate
-
-
?
urate + NADH + H+ + O2
5-hydroxyisourate + NAD+ + H2O
part of the purine catabolic pathway
-
-
?
urate + NADH + H+ + O2
5-hydroxyisourate + NAD+ + H2O
part of the purine catabolic pathway
-
-
?
urate + NADH + H+ + O2
5-hydroxyisourate + NAD+ + H2O
-
part of the purine catabolic pathway
unstable in aqueous buffer, hydrolyzing spontaneously to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline
-
?
urate + NADH + H+ + O2
5-hydroxyisourate + NAD+ + H2O
-
urate hydroxylase shows selectivity (V/K ratio of 10) for NADH over NADPH
unstable in aqueous buffer, hydrolyzing spontaneously to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline
-
?
urate + NADH + H+ + O2
5-hydroxyisourate + NAD+ + H2O
-
-
-
?
urate + NADH + H+ + O2
5-hydroxyisourate + NAD+ + H2O
the enzyme is slightly more efficient (about 2.6times) with NADPH than NADH
-
-
?
