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1.14.13.148: trimethylamine monooxygenase

This is an abbreviated version!
For detailed information about trimethylamine monooxygenase, go to the full flat file.

Word Map on EC 1.14.13.148

Reaction

N,N,N-trimethylamine
+
NADPH
+
H+
+
O2
=
N,N,N-trimethylamine N-oxide
+
NADP+
+
H2O

Synonyms

dimethyl sulfoxide/trimethylamine N-oxide reductase, EC 1.14.13.8, FAD-containing monooxygenase, flavin containing monooxygenase 3, flavin monooxygenase 3, flavin-containing monooxygenase, flavin-containing monooxygenase 3, FMO, FMO3, FMO4, PB7211, TMA monooxygenase, TMA N-oxygenase, TMM

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.148 trimethylamine monooxygenase

Disease

Disease on EC 1.14.13.148 - trimethylamine monooxygenase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenoma
Genetic polymorphisms of flavin monooxygenase 3 in sulindac-induced regression of colorectal adenomas in familial adenomatous polyposis.
Adenomatous Polyposis Coli
Genetic polymorphisms of flavin monooxygenase 3 in sulindac-induced regression of colorectal adenomas in familial adenomatous polyposis.
Genetic polymorphisms of human flavin monooxygenase 3 in sulindac-mediated primary chemoprevention of familial adenomatous polyposis.
Atherosclerosis
Emerging roles of flavin monooxygenase 3 in cholesterol metabolism and atherosclerosis.
Trimethylamine-N-oxide: a link between the gut microbiome, bile acid metabolism, and atherosclerosis.
Diabetes Mellitus, Type 2
Association between microbiota-dependent metabolite trimethylamine-N-oxide and type 2 diabetes.
Infections
Selective Modulation of Hepatic Cytochrome P450 and Flavin Monooxygenase 3 Expression during Citrobacter rodentium Infection in Severe Combined Immune-Deficient Mice.
Thrombosis
Flavin monooxygenase 3, the host hepatic enzyme in the metaorganismal trimethylamine N-oxide-generating pathway, modulates platelet responsiveness and thrombosis risk.
trimethylamine monooxygenase deficiency
Biochemical and molecular studies in mild flavin monooxygenase 3 deficiency.