1.14.13.148: trimethylamine monooxygenase
This is an abbreviated version!
For detailed information about trimethylamine monooxygenase, go to the full flat file.
Word Map on EC 1.14.13.148
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1.14.13.148
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1.14.13.8
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flavin-containing
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trimethylamine-n-oxide
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fad-containing
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trimethylaminuria
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methimazole
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n-oxygenation
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dimethylaniline
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s-oxidation
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n-octylamine
- 1.14.13.148
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1.14.13.8
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flavin-containing
- trimethylamine-n-oxide
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fad-containing
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trimethylaminuria
- methimazole
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n-oxygenation
- dimethylaniline
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s-oxidation
- n-octylamine
Reaction
Synonyms
dimethyl sulfoxide/trimethylamine N-oxide reductase, EC 1.14.13.8, FAD-containing monooxygenase, flavin containing monooxygenase 3, flavin monooxygenase 3, flavin-containing monooxygenase, flavin-containing monooxygenase 3, FMO, FMO3, FMO4, PB7211, TMA monooxygenase, TMA N-oxygenase, TMM
ECTree
1.14.13.148 trimethylamine monooxygenaseAdvanced search results
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results (Inhibitors
Inhibitors on EC 1.14.13.148 - trimethylamine monooxygenase
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
3-dimethylaminopropan-1-ol
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inhibitory at concentrations above about 1 mM
3-dimethylaminopropan-2-ol
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inhibitory at concentrations above about 1 mM
Cu2+
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0.2 mM Cu2+ inhibits the enzyme strongly without any preincubation
N,N-dimethyl-2-chloroethylamine
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inhibitory at concentrations above about 1 mM
N,N-dimethylethanolamine
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inhibitory at concentrations above about 1 mM
N,N-dimethylethylenediamine
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inhibitory at concentrations above about 1 mM
N,N-dimethylpropylenediamine
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inhibitory at concentrations above about 1 mM
N-ethylmaleimide
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preincubation of the enzyme for 15 min at 14°C, pH 7.7, in the presence of 1.0 mM N-ethylmaleimide inhibits the enzymatic activity approximately by 25%
p-chloromercuribenzoate
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preincubation of the enzyme for 15 min at 14°C, pH 7.7, in the presence of 0.2 mM p-chloromercuribenzoate inhibits the enzymic activity approximately by 90%
Thiourea
thiourea reduces ethionamide oxygenation to ethionamide S-oxide by an average of 73.5% in liver and 76.9% in lung
additional information
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the enzyme is not inhibited by CO, cyanide or SKF 525-A (2-diethylaminoethyl 2,2-diphenylvalerate hydrochloride), nor by chelating agents
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additional information
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10 mM EDTA, 1 mM potassium cyanide and 1 mM sodium azide do not inhibit the enzyme. Bubbling the enzyme solution with CO for 2 min at 0°C or including CO (CO:O2 ratio 1:1) during the tests has no effect on enzyme activity
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additional information
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enzyme reactions are not inhibited by gas phase containing up to 80% carbon monoxide/20% oxygen mixture
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