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1.14.13.154: erythromycin 12-hydroxylase

This is an abbreviated version!
For detailed information about erythromycin 12-hydroxylase, go to the full flat file.

Word Map on EC 1.14.13.154

Reaction

erythromycin D
+
NADPH
+
H+
+
O2
=
erythromycin C
+
NADP+
+
H2O

Synonyms

CYP113A1, EryK, erythromycin C-12 hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.154 erythromycin 12-hydroxylase

Substrates Products

Substrates Products on EC 1.14.13.154 - erythromycin 12-hydroxylase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
erythromycin B + NADPH + H+ + O2
erythromycin A + NADP+ + H2O
show the reaction diagram
-
1200-1900-fold preference for erythromycin D over the alternative C-12 hydroxylase substrate erythromycin B
-
-
?
erythromycin D + NADPH + H+ + O2
erythromycin C + NADP+ + H2O
show the reaction diagram
additional information
?
-