1.14.13.168: indole-3-pyruvate monooxygenase

This is an abbreviated version!
For detailed information about indole-3-pyruvate monooxygenase, go to the full flat file.

Reaction

Synonyms

At5g25620, Cc06_g09670, flavin-containing monooxygenase YUC, spi1, YUC, YUC1, YUC10, YUC10.3, YUC11, YUC2, YUC3, YUC4, YUC5, YUC6, YUC7, YUC8, YUC9, YUCCA, YUCCA1, YUCCA2, YUCCA4, YUCCA6

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.13.168 indole-3-pyruvate monooxygenase

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Results	in table
46	AA Sequence
4	Cloned(Commentary)
7	Cofactor
1	Crystallization (Commentary)
9	General Information
13	Inhibitors
2	Ki Value [mM]
2	KM Value [mM]
4	Localization
1	Metals/Ions
1	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
14	Organism
4	Pathway
1	pH Optimum
7	Protein Variants
1	Purification (Commentary)
1	Reaction
13	Reference
5	Source Tissue
7	Substrates and Products (Substrate)
1	Subunits
39	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 1.14.13.168 - indole-3-pyruvate monooxygenase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

(indol-3-yl)pyruvate + NADPH + H+ + O2

(indol-3-yl)acetate + NADP+ + H2O + CO2

6 entries

phenylpyruvate + NADPH + H+ + O2

phenylacetate + NADP+ + H2O + CO2

Arabidopsis thaliana

Q8VZ59

isoform YUC6 shows basal NADPH oxidase activity in the absence of the cosubstrate phenylpyruvate

720064

-

-

?

(indol-3-yl)pyruvate + NADPH + H+ + O2

(indol-3-yl)acetate + NADP+ + H2O + CO2

Arabidopsis thaliana

Q8VZ59

-

720064

-

-

?

(indol-3-yl)pyruvate + NADPH + H+ + O2

(indol-3-yl)acetate + NADP+ + H2O + CO2

Arabidopsis thaliana

-

-

720921

-

-

?

(indol-3-yl)pyruvate + NADPH + H+ + O2

(indol-3-yl)acetate + NADP+ + H2O + CO2

Arabidopsis thaliana

-

-

720508

-

-

ir

(indol-3-yl)pyruvate + NADPH + H+ + O2

(indol-3-yl)acetate + NADP+ + H2O + CO2

Arabidopsis thaliana

Q8VZ59, Q9LFM5, Q9SVQ1, Q9SZY8

-

720688

-

-

?

(indol-3-yl)pyruvate + NADPH + H+ + O2

(indol-3-yl)acetate + NADP+ + H2O + CO2

Arabidopsis thaliana

Q9SVQ1

-

746081

-

-

?

(indol-3-yl)pyruvate + NADPH + H+ + O2

(indol-3-yl)acetate + NADP+ + H2O + CO2

Arabidopsis thaliana

Q8VZ59

-

720064

first step of the YUC6-catalyzed reaction is the reduction of the FAD cofactor to FADH- by NADPH. Subsequently, FADH- reacts with oxygen to form a flavin-C4a-(hydro)peroxy intermediate, which has a maximum absorbance at 381 nm in its UV-visible spectrum. The final chemical step is the reaction of the C4a-intermediate with (indol-3-yl)pyruvate to produce (indol-3-yl)acetate. The YUC6 intermediate has a half-life of about 20 s

-

?