1.14.13.180: aklavinone 12-hydroxylase

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For detailed information about aklavinone 12-hydroxylase, go to the full flat file.

Reaction

Synonyms

aklavinone 12-hydroxylase, DnrF, RdmE

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.13.180 aklavinone 12-hydroxylase

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Results	in table
47	AA Sequence
1	Application
5	Cloned(Commentary)
5	Cofactor
2	Crystallization (Commentary)
2	General Information
2	Inhibitors
4	KM Value [mM]
3	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
10	Organism
5	Pathway
1	pH Optimum
1	pI Value
5	Protein Variants
1	Purification (Commentary)
1	Reaction
10	Reference
12	Substrates and Products (Substrate)
4	Subunits
11	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Systematic Name

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Systematic Name on EC 1.14.13.180 - aklavinone 12-hydroxylase

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SYSTEMATIC NAME

IUBMB Comments

aklavinone,NADPH:oxygen oxidoreductase (12-hydroxylating)

The enzymes from the Gram-positive bacteria Streptomyces peucetius and Streptomyces purpurascens participate in the biosynthesis of daunorubicin, doxorubicin and rhodomycins. The enzyme from Streptomyces purpurascens is an FAD monooxygenase.