1.14.13.181: 13-deoxydaunorubicin hydroxylase

This is an abbreviated version!
For detailed information about 13-deoxydaunorubicin hydroxylase, go to the full flat file.

Reaction

Synonyms

CYP109A2, DoxA, DoxA monooxygenase

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

1.14.13.181 13-deoxydaunorubicin hydroxylase

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Results	in table
5	AA Sequence
3	Cloned(Commentary)
6	Cofactor
6	General Information
6	Inhibitors
4	kcat/KM [mM/s]
1	Ki Value [mM]
4	KM Value [mM]
4	Molecular Weight [Da]
13	Natural Substrates/ Products (Substrates)
10	Organism
6	Pathway
1	pH Optimum
2	Purification (Commentary)
2	Reaction
9	Reference
1	Source Tissue
1	Specific Activity [micromol/min/mg]
1	Storage Stability
25	Substrates and Products (Substrate)
5	Subunits
11	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Stability [°C]
4	Turnover Number [1/s]

General Information

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General Information on EC 1.14.13.181 - 13-deoxydaunorubicin hydroxylase

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malfunction

Streptomyces peucetius

the block in the SPDHC mutant is probably due to a defective C-13 oxidation activity of DoxA. Since this mutant accumulates 13-dihydrocarminomycin, the C-13 hydroxylation activity of DoxA is probably not affected

722882

physiological function

3 entries

additional information

2 entries