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1.14.13.181: 13-deoxydaunorubicin hydroxylase

This is an abbreviated version!
For detailed information about 13-deoxydaunorubicin hydroxylase, go to the full flat file.

Reaction

13-deoxydaunorubicin
+
NADPH
+
H+
+
O2
=
13-dihydrodaunorubicin
+
NADP+
+
H2O

Synonyms

CYP109A2, DoxA, DoxA monooxygenase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.181 13-deoxydaunorubicin hydroxylase

Systematic Name

Systematic Name on EC 1.14.13.181 - 13-deoxydaunorubicin hydroxylase

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SYSTEMATIC NAME
IUBMB Comments
13-deoxydaunorubicin,NADPH:oxygen oxidoreductase (13-hydroxylating)
The enzymes from the Gram-positive bacteria Streptomyces sp. C5 and Streptomyces peucetius show broad substrate specificity for structures based on an anthracycline aglycone, but have a strong preference for 4-methoxy anthracycline intermediates (13-deoxydaunorubicin and 13-dihydrodaunorubicin) over their 4-hydroxy analogues (13-deoxycarminomycin and 13-dihydrocarminomycin), as well as a preference for substrates hydroxylated at the C-13 rather than the C-14 position.