1.14.13.187: L-evernosamine nitrososynthase
This is an abbreviated version!
For detailed information about L-evernosamine nitrososynthase, go to the full flat file.
Word Map on EC 1.14.13.187
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1.14.13.187
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thymidine
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monooxygenase
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micromonospora
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anthracycline
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flavin-dependent
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africana
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peucetius
- 1.14.13.187
- thymidine
- monooxygenase
- micromonospora
-
anthracycline
-
flavin-dependent
- africana
- peucetius
Reaction
+ 2 NADPH + 2 H+ + 2 O2 = + 2 NADP+ + 3 H2O
Synonyms
DnmZ, nitrososynthase, ORF36
ECTree
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Cofactor
Cofactor on EC 1.14.13.187 - L-evernosamine nitrososynthase
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FMN
the predicted flavin-binding site is formed by residues emanating from all three DnmZ domains and the loop connecting alpha8 and alpha9 from a neighboring chain. Numerous nonpolar amino-acid side chains form a hydrophobic pocket that can accommodate the dimethylbenzene portion of the flavin cofactor. A hydrogen-bonding network including Ser174, Ser223, Ser225 and Trp215 holds the protein surface in the correct conformation to allow hydrogenbonding interactions with the flavin isoalloxazine, including a hydrogen bond between the flavin N5 atom and Ser174. This interaction is conserved in the flavin monooxygenases and is thought to play a role in stabilizing the hydroperoxyflavin intermediate