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1.14.13.25: methane monooxygenase (soluble)

This is an abbreviated version!
For detailed information about methane monooxygenase (soluble), go to the full flat file.

Word Map on EC 1.14.13.25

Reaction

methane
+
NAD(P)H
+
H+
+
O2
=
methanol
+
NAD(P)+
+
H2O

Synonyms

chcA, cytoplasmic methane monooxygenase, methane hydroxylase, methane mono-oxygenase, methane monooxygenase, methane monooxygenase hydroxylase, MmMmoC, MMO, MMO Bath, MMOB, MmoC, MMOH, MMOR, oxygenase, methane mono-, particulate methane monooxygenase, pMMO, sMMO, soluble methane monooxygenase, soluble methane monooxygenase hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.25 methane monooxygenase (soluble)

Inhibitors

Inhibitors on EC 1.14.13.25 - methane monooxygenase (soluble)

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2,3-Dimercaptopropan-1-ol
-
-
2,4-Dichloro-(6-phenylphenoxy)ethylamine hydrochloride
2,4-Dichloro-(6-phenylphenoxy)ethyldiethylamine
-
-
2-mercaptoethanol
-
-
3-Amino-1,2,4-triazole
-
-
8-hydroxyquinoline
Acetylene
Allylthiourea
ammonium chloride
-
slightly
Cd2+
-
soluble enzyme form more than the membrane-bound form
chloramphenicol
-
sMMO
Co2+
-
slightly, sMMO
Dichloromethane
-
competitively in presence of formate
Dimercaptopropanol
-
-
Dithionite
-
34% inhibition at 5 mM
dithiothreitol
-
-
DTT
-
24% inhibition at 20 mM
ethyl carbamate
-
-
glycerol
-
40% inhibition at 15%
Hg2+
-
complete inhibition at 0.01 mM
methylamine
-
slightly
N2
-
N2 atmosphere causes 28% inhibition
o-phenanthroline
-
-
poly-beta-hydroxybutyrate
protein MMOB
-
inhibition of sMMO auxiliary proteins MMOB or MMOD severely diminishes electron-transfer throughput from MMOR, primarily by shifting the bulk of electron transfer to the slowest pathway, the biphasic reactions for electron transfer to MMOH from several MMOR ferredoxin analogues are also inhibited, overview
-
protein MMOD
-
inhibition of sMMO auxiliary proteins MMOB or MMOD severely diminishes electron-transfer throughput from MMOR, primarily by shifting the bulk of electron transfer to the slowest pathway, the biphasic reactions for electron transfer to MMOH from several MMOR ferredoxin analogues are also inhibited, overview
-
Thiosemicarbazide
-
-
trichlorethylene
-
non-competitively; pMMO
additional information
-