1.14.13.34: leukotriene-E4 20-monooxygenase
This is an abbreviated version!
For detailed information about leukotriene-E4 20-monooxygenase, go to the full flat file.
Reaction
Synonyms
leukotriene-E4 omega-hydroxylase, oxygenase, leukotriene E4 20-mono
ECTree
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Substrates Products
Substrates Products on EC 1.14.13.34 - leukotriene-E4 20-monooxygenase
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REACTION DIAGRAM
(7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate + NADPH + O2
20-hydroxy-leukotriene E4 + NADP+ + H2O
20-hydroxy-leukotriene E4 + NADP+ + H2O
-
leukotriene E4
omega-hydroxy-leukotriene E4
?
(7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate + NADPH + O2
20-hydroxy-leukotriene E4 + NADP+ + H2O
-
leukotriene E4
omega-hydroxy-leukotriene E4
?
(7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate + NADPH + O2
20-hydroxy-leukotriene E4 + NADP+ + H2O
-
metabolism of leukotriene E4 and N-acetyl-leukotriene E4 in rat liver microsomes
-
?
N-acetyl-omega-hydroxy-leukotriene E4 + NADP+ + H2O
-
-
-
?
N-acetyl-leukotriene E4 + NADPH + O2
N-acetyl-omega-hydroxy-leukotriene E4 + NADP+ + H2O
-
at a rate six times lower than leukotriene E4
-
?