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NADPH-diaphorase reactive/NO synthase -immunoreactive materials are localized on the nuclear envelope and membrane segments of the rough and smooth endoplasmic reticulum, as well as the cell membrane and axolemma of positive perikarya
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NADPH-diaphorase reactive/NO synthase -immunoreactive materials are localized on the nuclear envelope and membrane segments of the rough and smooth endoplasmic reticulum, as well as the cell membrane and axolemma of positive perikarya
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isozyme nNOS
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NADPH-diaphorase reactive/NO synthase -immunoreactive materials are localized on the nuclear envelope and membrane segments of the rough and smooth endoplasmic reticulum, as well as the cell membrane and axolemma of positive perikarya
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NADPH-diaphorase reactive/NO synthase -immunoreactive materials are localized on the nuclear envelope and membrane segments of the rough and smooth endoplasmic reticulum, as well as the cell membrane and axolemma of positive perikarya
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iNOS contains several characteristic endoplasmic reticulum (ER)-localization sequences. iNOS is likely to be glycosylated in the endoplasmic reticulum
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iNOS contains several characteristic endoplasmic reticulum (ER)-localization sequences. iNOS is likely to be glycosylated in the endoplasmic reticulum
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constitutive endothelial enzyme: predominantly membrane-bound, inducible macrophage enzyme: equally distributed between cytosol and membrane, small constitutive membrane-bound portion in murine macrophages
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NADPH-diaphorase reactive/NO synthase -immunoreactive materials are localized on the nuclear envelope and membrane segments of the rough and smooth endoplasmic reticulum, as well as the cell membrane and axolemma of positive perikarya
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NADPH-diaphorase reactive/NO synthase -immunoreactive materials are localized on the nuclear envelope and membrane segments of the rough and smooth endoplasmic reticulum, as well as the cell membrane and axolemma of positive perikarya
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constitutive endothelial enzyme: predominantly membrane-bound, inducible macrophage enzyme: equally distributed between cytosol and membrane, small constitutive membrane-bound portion in murine macrophages
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total NOS activity is enriched in the intracellular membrane fraction at normal salt diet
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distinct enzyme not identical to other known isoforms
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isozyme NOS1 contains a mitochondrial targeting signal
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isozyme iNOS
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NADPH-diaphorase reactive/NO synthase-immunoreactive materials are localized on the nuclear envelope and membrane segments of the rough and smooth endoplasmic reticulum, as well as the cell membrane and axolemma of positive perikarya
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NADPH-diaphorase reactive/NO synthase -immunoreactive materials are localized on the nuclear envelope and membrane segments of the rough and smooth endoplasmic reticulum, as well as the cell membrane and axolemma of positive perikarya
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NADPH-diaphorase reactive and NO synthase-immunoreactive varicosities connect to neighboring neurons with both unspecialized and specialized synaptic contacts
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in the varicosities, the majority of the NADPH-d reactive/NOS-immunoreactive membrane segments are detected in round and pleomorph agranular vesicles of small size (50-200 nm)
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NADPH-diaphorase reactive and NO synthase-immunoreactive varicosities connect to neighboring neurons with both unspecialized and specialized synaptic contacts
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in the varicosities, the majority of the NADPH-d reactive/NOS-immunoreactive membrane segments are detected in round and pleomorph agranular vesicles of small size (50-200 nm)
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additional information
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3 isoforms: 1. neuronal, soluble isoform I is constitutively expressed in brain and other tissues and Ca2+-regulated, 2. soluble isoform II is usually not constitutively expressed, but inducible in macrophages and other cells, 3. isoform III is membrane-bound and expressed in endothelial cells
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additional information
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no evidence for the postsynaptic location is found
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additional information
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3 isoforms: 1. neuronal, soluble isoform I is constitutively expressed in brain and other tissues and Ca2+-regulated, 2. soluble isoform II is usually not constitutively expressed, but inducible in macrophages and other cells, 3. isoform III is membrane-bound and expressed in endothelial cells
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additional information
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no evidence for the postsynaptic location is found
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additional information
no evidence for the postsynaptic location is found
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additional information
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3 distinct isoforms: 1. a membrane-associated, constitutive enzyme from the vascular endothelium, 2. a soluble, constitutive enzyme from neuronal cells, 3. an endotoxin- and cytokine-inducible enzyme exemplified by that from murine macrophages
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additional information
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3 isoforms: 1. neuronal, soluble isoform I is constitutively expressed in brain and other tissues and Ca2+-regulated, 2. soluble isoform II is usually not constitutively expressed, but inducible in macrophages and other cells, 3. isoform III is membrane-bound and expressed in endothelial cells
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additional information
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activity of constitutive enzymes is regulated by binding of calmodulin and Ca2+, the inducible enzyme is regulated by binding of calmodulin, not by Ca2+
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additional information
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subcellular distribution of NOS1
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additional information
N-glycosylation of proteins starts in the endoplasmic reticulum, continues in the Golgi, and ends at the plasma membrane. As mentioned above, iNOS has characteristic ER localization sequences and locates in the Golgi and cell membrane. iNOS is located both in cytoplasm and on cell membrane, it is not only a cytoplasmic protein but also a membrane protein
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additional information
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N-glycosylation of proteins starts in the endoplasmic reticulum, continues in the Golgi, and ends at the plasma membrane. As mentioned above, iNOS has characteristic ER localization sequences and locates in the Golgi and cell membrane. iNOS is located both in cytoplasm and on cell membrane, it is not only a cytoplasmic protein but also a membrane protein
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additional information
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N-glycosylation of proteins starts in the endoplasmic reticulum, continues in the Golgi, and ends at the plasma membrane. As mentioned above, iNOS has characteristic ER localization sequences and locates in the Golgi and cell membrane. iNOS is located both in cytoplasm and on cell membrane, it is not only a cytoplasmic protein but also a membrane protein
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additional information
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3 isoforms: 1. neuronal, soluble isoform I is constitutively expressed in brain and other tissues and Ca2+-regulated, 2. soluble isoform II is usually not constitutively expressed, but inducible in macrophages and other cells, 3. isoform III is membrane-bound and expressed in endothelial cells
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additional information
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3 isoforms: 1. neuronal, soluble isoform I is constitutively expressed in brain and other tissues and Ca2+-regulated, 2. soluble isoform II is usually not constitutively expressed, but inducible in macrophages and other cells, 3. isoform III is membrane-bound and expressed in endothelial cells
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additional information
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subcellular distribution of NOS and caveolin-1, nNOS and iNOS are co-localized with caveolin-1, overview
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additional information
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3 isoforms: 1. neuronal, soluble isoform I is constitutively expressed in brain and other tissues and Ca2+-regulated, 2. soluble isoform II is usually not constitutively expressed, but inducible in macrophages and other cells, 3. isoform III is membrane-bound and expressed in endothelial cells
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additional information
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3 isoforms: 1. neuronal, soluble isoform I is constitutively expressed in brain and other tissues and Ca2+-regulated, 2. soluble isoform II is usually not constitutively expressed, but inducible in macrophages and other cells, 3. isoform III is membrane-bound and expressed in endothelial cells
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