1.14.13.40: anthraniloyl-CoA monooxygenase
This is an abbreviated version!
For detailed information about anthraniloyl-CoA monooxygenase, go to the full flat file.
Word Map on EC 1.14.13.40
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1.14.13.40
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flavoproteins
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denitrifying
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flavoenzyme
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azoarcus
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2-aminobenzoate
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evansii
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monooxygenation
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thioesters
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non-aromatic
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dearomatized
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flavin
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yellow
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borohydride
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fuchs
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n-ethylmaleimide
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salicylate
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alicyclic
- 1.14.13.40
- flavoproteins
-
denitrifying
-
flavoenzyme
-
azoarcus
- 2-aminobenzoate
- evansii
-
monooxygenation
- thioesters
-
non-aromatic
-
dearomatized
- flavin
- yellow
- borohydride
-
fuchs
- n-ethylmaleimide
- salicylate
-
alicyclic
Reaction
Synonyms
2-aminobenzoyl-CoA monooxygenase/reductase, ACMR, anthranoyl-CoA monooxygenase/reductase, reductase, anthraniloyl coenzyme A
ECTree
1.14.13.40 anthraniloyl-CoA monooxygenaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 1.14.13.40 - anthraniloyl-CoA monooxygenase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-aminobenzoyl-CoA + NAD(P)H + O2
2-amino-5-oxocyclohex-1-enecarboxyl-CoA + H2O + NAD(P)+
anthraniloyl-CoA + 2 NAD(P)H + 2 H+ + O2
2-amino-5-oxocyclohex-1-enecarboxyl-CoA + H2O + 2 NAD(P)+
2-aminobenzoyl-CoA + NAD(P)H + O2
2-amino-5-oxocyclohex-1-enecarboxyl-CoA + H2O + NAD(P)+
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reaction mechanism
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-
?
2-aminobenzoyl-CoA + NAD(P)H + O2
2-amino-5-oxocyclohex-1-enecarboxyl-CoA + H2O + NAD(P)+
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-
-
-
?
2-aminobenzoyl-CoA + NAD(P)H + O2
2-amino-5-oxocyclohex-1-enecarboxyl-CoA + H2O + NAD(P)+
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-
formation of 3 different products, the non-aromatic product is unstable and releases CO2 and NH3, forming 1,4-cyclohexadione
?
2-aminobenzoyl-CoA + NAD(P)H + O2
2-amino-5-oxocyclohex-1-enecarboxyl-CoA + H2O + NAD(P)+
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-
at least 2 different reaction products depending on the concentration of NADH
?
2-aminobenzoyl-CoA + NAD(P)H + O2
2-amino-5-oxocyclohex-1-enecarboxyl-CoA + H2O + NAD(P)+
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-
7 different products are formed, pattern is dependent on pH
?
2-aminobenzoyl-CoA + NAD(P)H + O2
2-amino-5-oxocyclohex-1-enecarboxyl-CoA + H2O + NAD(P)+
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-
product formed under physiological NADH concentration
?
2-aminobenzoyl-CoA + NAD(P)H + O2
2-amino-5-oxocyclohex-1-enecarboxyl-CoA + H2O + NAD(P)+
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i.e. anthraniloyl-CoA
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-
?
2-aminobenzoyl-CoA + NAD(P)H + O2
2-amino-5-oxocyclohex-1-enecarboxyl-CoA + H2O + NAD(P)+
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pathway of aerobic breakdown of 2-aminobenzoate
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-
?
2-aminobenzoyl-CoA + NAD(P)H + O2
2-amino-5-oxocyclohex-1-enecarboxyl-CoA + H2O + NAD(P)+
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-
7 different products are formed, pattern is dependent on pH
?
2-aminobenzoyl-CoA + NAD(P)H + O2
2-amino-5-oxocyclohex-1-enecarboxyl-CoA + H2O + NAD(P)+
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-
-
-
?
2-aminobenzoyl-CoA + NAD(P)H + O2
2-amino-5-oxocyclohex-1-enecarboxyl-CoA + H2O + NAD(P)+
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pathway of aerobic breakdown of 2-aminobenzoate
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-
?
2-aminobenzoyl-CoA + NAD(P)H + O2
2-amino-5-oxocyclohex-1-enecarboxyl-CoA + H2O + NAD(P)+
-
-
at least 2 different reaction products depending on the concentration of NADH
?
2-aminobenzoyl-CoA + NAD(P)H + O2
2-amino-5-oxocyclohex-1-enecarboxyl-CoA + H2O + NAD(P)+
-
-
-
-
?
2-aminobenzoyl-CoA + NAD(P)H + O2
2-amino-5-oxocyclohex-1-enecarboxyl-CoA + H2O + NAD(P)+
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i.e. anthraniloyl-CoA
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-
?
2-aminobenzoyl-CoA + NAD(P)H + O2
2-amino-5-oxocyclohex-1-enecarboxyl-CoA + H2O + NAD(P)+
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-
7 different products are formed, pattern is dependent on pH
?
2-hydroxybenzoyl-CoA + NAD(P)H + O2
?
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i.e. salicoyl-CoA, weak substrate, is probably monooxygenated but not hydrogenated
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?
2-hydroxybenzoyl-CoA + NAD(P)H + O2
?
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i.e. salicoyl-CoA, weak substrate, is probably monooxygenated but not hydrogenated
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-
?
anthraniloyl-CoA + 2 NAD(P)H + 2 H+ + O2
2-amino-5-oxocyclohex-1-enecarboxyl-CoA + H2O + 2 NAD(P)+
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the enzyme participates in a pathway for the degradation of aromatic compounds in Azoarcus evansii
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?
anthraniloyl-CoA + 2 NAD(P)H + 2 H+ + O2
2-amino-5-oxocyclohex-1-enecarboxyl-CoA + H2O + 2 NAD(P)+
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the enzyme catalyzes the monooxygenation of anthranoyl-CoA to 5-hydroxyl-2-aminobenzoyl-CoA and the subsequent reduction to the dearomatized product 2-amino-5-oxo-cyclohex-1-ene-1-carbonyl-CoA. The two reactions occur in separate domains, termed the monooxygenase and reductase domain. Binding studies with 2-aminobenzoyl-CoA and p-hydroxybenzaldehyde as probes for the monooxygenase and reductase domain, respectively, indicate that two functionally distinct and independent active sites exist
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-
?
anthraniloyl-CoA + NADH + H+ + O2
2-amino-5-oxocyclohex-1-enecarboxyl-CoA + H2O + NAD+
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-
-
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r
anthraniloyl-CoA + NADH + H+ + O2
2-amino-5-oxocyclohex-1-enecarboxyl-CoA + H2O + NAD+
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-
-
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r
N-ethylmaleimide + NAD(P)H + H+
N-ethylsuccinimide + NAD(P)+
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-
-
?
