1.14.13.59: L-lysine N6-monooxygenase (NADPH)

This is an abbreviated version!
For detailed information about L-lysine N6-monooxygenase (NADPH), go to the full flat file.

Word Map on EC 1.14.13.59

1.14.13.59

fad

siderophore

flavoproteins

ornithine

nicotinamide

c4a-hydroperoxyflavin

hydroxamate

nadp+

hydroxamate-containing

oxygen-dependent

5-aminovalerate

aerobactin

glutarate

semialdehyde

flavin-containing

iodoacetate

fumigatus

Reaction

Synonyms

EC 1.13.12.10, EC 13.12.10, flavin-dependent lysine monooxygenase, flavin-dependent N6-lysine monooxygenase, IucD, LH, lysine monooxygenase, Lysine N(6)-hydroxylase, Lysine N6-hydroxylase, lysine N6-monooxygenase, lysine: N6-hydroxylase, lysine:N(6)-hydroxylase, Lysine:N6-hydroxylase, MbsG, N-hydroxylating monooxygenase, NbtG, Oxygenase, lysine N6-mono-

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

1.14.13.59 L-lysine N6-monooxygenase (NADPH)

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Results	in table
4	Activating Compound
6102	AA Sequence
1	CAS Registry Number
5	Cloned(Commentary)
36	Cofactor
1	Crystallization (Commentary)
4	General Information
1	General Stability
10	Inhibitors
20	kcat/KM [mM/s]
1	Ki Value [mM]
38	KM Value [mM]
5	Localization
2	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
19	Organism
8	Pathway
4	PDB ID
7	pH Optimum
2	pH Range
25	Protein Variants
4	Purification (Commentary)
5	Reaction
2	Reaction Type
17	Reference
9	Specific Activity [micromol/min/mg]
1	Storage Stability
47	Substrates and Products (Substrate)
5	Subunits
29	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
28	Turnover Number [1/s]

Specific Activity

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Specific Activity on EC 1.14.13.59 - L-lysine N6-monooxygenase (NADPH)

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0.00016

Escherichia coli

recombinant mutant P14G, with 0.005 mM FAD, and NADPH

658232

0.0011

Escherichia coli

recombinant mutant P14G, with 0.005 mM FAD, and iodine

658232

0.0039

Escherichia coli

recombinant mutant P14G, with 0.3 mM FAD, and NADPH

658232

0.028

Escherichia coli

recombinant mutant P14G, with 0.3 mM FAD, and iodine

0.168

0.189

0.238

0.3

recombinant wild-type enzyme, with 0.005 mM FAD, and iodine

658232

0.444

Escherichia coli

recombinant wild-type enzyme, with 0.005 mM FAD, and NADPH

658232