1.14.13.7: phenol 2-monooxygenase (NADPH)

This is an abbreviated version!
For detailed information about phenol 2-monooxygenase (NADPH), go to the full flat file.

Reaction

Synonyms

DmpLNO, flavin containing monooxygenase, LmPH, Mph, MphN, multi-component phenol hydroxylase, multicomponent PH, multicomponent phenol hydroxylase, multicomponent phenol hydroxylase alpha subunit, NCgl2588, oxygenase, phenol 2-mono-, PHE, phenol hydroxylase, phenol o-hydroxylase, PHH, phhY, PHIND, PHO, PHR, single-component PH, SPH

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.13.7 phenol 2-monooxygenase (NADPH)

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Results	in table
4	Activating Compound
1301	AA Sequence
16	Application
1	CAS Registry Number
27	Cloned(Commentary)
55	Cofactor
4	Crystallization (Commentary)
1	Expression
4	General Information
5	General Stability
78	Inhibitors
22	Ki Value [mM]
57	KM Value [mM]
4	Localization
10	Metals/Ions
17	Molecular Weight [Da]
46	Natural Substrates/ Products (Substrates)
192	Organism
7	Pathway
9	PDB ID
17	pH Optimum
6	pH Range
1	pH Stability
3	pI Value
12	Protein Variants
18	Purification (Commentary)
3	Reaction
3	Reaction Type
97	Reference
15	Source Tissue
17	Specific Activity [micromol/min/mg]
4	Storage Stability
324	Substrates and Products (Substrate)
27	Subunits
171	Synonyms
1	Systematic Name
14	Temperature Optimum [°C]
3	Temperature Range [°C]
2	Temperature Stability [°C]
15	Turnover Number [1/s]

General Information

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General Information on EC 1.14.13.7 - phenol 2-monooxygenase (NADPH)

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

metabolism

uncultured microorganism

-

the enzyme is an indicator of aerobic benzene, toluene, ethylbenzene, and xylenes biodegradation potential

703484

physiological function

Geobacillus stearothermophilus

-

the enzyme is a component of the operon encoding the meta-pathway genes, it catalyzes the first step of the phenol degradative meta-pathway

691504

additional information

2 entries

additional information

Pseudomonas sp.

-

PHK, the accessory component of the phenol hydroxylase, is neither involved in the catalytic activity of the phenol hydroxylase complex nor required for the assembly of apo-hydroxylase, but may be responsible for enhancing iron incorporation into the active site of the apo-hydroxylase

711022

additional information

Pseudomonas sp. OX1

-

PHK, the accessory component of the phenol hydroxylase, is neither involved in the catalytic activity of the phenol hydroxylase complex nor required for the assembly of apo-hydroxylase, but may be responsible for enhancing iron incorporation into the active site of the apo-hydroxylase

-