1.14.13.8: flavin-containing monooxygenase

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Reaction

Synonyms

class 3 flavin-containing mono-oxygenase, class 3 FMO, dechlorinating flavin-dependent monooxygenase, dimethylaniline monooxygenase (N-oxide-forming), dimethylaniline monooxygenase [N-oxide-forming] 1, dimethylaniline N-oxidase, dimethylaniline oxidase, dimethylsulfone monooxygenase, DMA oxidase, EC 1.13.12.11, EC 1.8.1.3, EtaA, FAD-containing monooxygenase, FAD-containing monooxygenase 3, flavin containing monooxygenase 3, flavin mono-oxygenase, flavin monooxygenase, flavin-containing mono-oxygenase, flavin-containing monooxygenase, flavin-containing monooxygenase 1, flavin-containing monooxygenase 3, flavin-containing monooxygenase 5, flavin-containing monooxygenase-3, flavin-containing-monooxygenase, flavin-dependent monooxygenase, flavoprotein monooxygenase, FMO, FMO 1A1, FMO 1B1, FMO 1C1, FMO 1D1, FMO 1E1, FMO-E, FMO-I, FMO-II, FMO1, FMO2, FMO2.1, FMO3, FMO4, FMO5, FMOGS-OX6, FMOGS-OX7, HadA, hFMO1, hFMO3, hFMO5, Met S-oxidase, mFMO, mixed-function amine oxidase, monooxygenase FMO1, More, MymA, N,N-dimethylaniline monooxygenase, oxygenase, dimethylaniline mono- (N-oxide-forming), oxygenase, methylphenyltetrahydropyridine N-mono-, PtFMO, sfnG, TetX, type II flavin-containing monooxygenase

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.13.8 flavin-containing monooxygenase

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Results	in table
30	Activating Compound
1797	AA Sequence
1	Application
4	CAS Registry Number
72	Cloned(Commentary)
237	Cofactor
4	Crystallization (Commentary)
201	Disease/ Diagnostics
25	Expression
40	General Information
2	General Stability
4	IC50 Value
98	Inhibitors
84	kcat/KM [mM/s]
7	Ki Value [mM]
272	KM Value [mM]
92	Localization
4	Metals/Ions
27	Molecular Weight [Da]
159	Natural Substrates/ Products (Substrates)
216	Organism
4	Pathway
48	PDB ID
70	pH Optimum
21	pH Range
1	pH Stability
1	pI Value
2	Posttranslational Modification
193	Protein Variants
34	Purification (Commentary)
15	Reaction
6	Reaction Type
194	Reference
258	Source Tissue
40	Specific Activity [micromol/min/mg]
3	Storage Stability
760	Substrates and Products (Substrate)
36	Subunits
326	Synonyms
1	Systematic Name
50	Temperature Optimum [°C]
1	Temperature Range [°C]
18	Temperature Stability [°C]
123	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.14.13.8 - flavin-containing monooxygenase

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SYSTEMATIC NAME

IUBMB Comments

N,N-dimethylaniline,NADPH:oxygen oxidoreductase (N-oxide-forming)

A flavoprotein. A broad spectrum monooxygenase that accepts substrates as diverse as hydrazines, phosphines, boron-containing compounds, sulfides, selenides, iodide, as well as primary, secondary and tertiary amines [3,4]. This enzyme is distinct from other monooxygenases in that the enzyme forms a relatively stable hydroperoxy flavin intermediate [4,5]. This microsomal enzyme generally converts nucleophilic heteroatom-containing chemicals and drugs into harmless, readily excreted metabolites. For example, N-oxygenation is largely responsible for the detoxification of the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) [2,6]