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1.14.14.13: 4-(gamma-L-glutamylamino)butanoyl-[BtrI acyl-carrier protein] monooxygenase

This is an abbreviated version!
For detailed information about 4-(gamma-L-glutamylamino)butanoyl-[BtrI acyl-carrier protein] monooxygenase, go to the full flat file.

Reaction

4-(gamma-L-glutamylamino)butanoyl-[BtrI acyl-carrier protein]
+
FMNH2
+
O2
=
4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI acyl-carrier protein]
+
FMN
+
H2O

Synonyms

btrO

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.13 4-(gamma-L-glutamylamino)butanoyl-[BtrI acyl-carrier protein] monooxygenase

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Resultsin table
7AA Sequence
1Cloned(Commentary)
2Cofactor
1General Information
2Molecular Weight [Da]
1Organism
3Pathway
1Reaction
1Reference
4Substrates and Products (Substrate)
1Subunits
2Synonyms
1Systematic Name

Systematic Name

Systematic Name on EC 1.14.14.13 - 4-(gamma-L-glutamylamino)butanoyl-[BtrI acyl-carrier protein] monooxygenase

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SYSTEMATIC NAME
IUBMB Comments
4-(gamma-L-glutamylamino)butanoyl-[BtrI acyl-carrier protein],FMN:oxygen oxidoreductase (2-hydroxylating)
Catalyses a step in the biosynthesis of the side chain of the aminoglycoside antibiotics of the butirosin family. FMNH2 is used as a free cofactor. Forms a complex with a dedicated NAD(P)H:FMN oxidoreductase. The enzyme is not able to hydroxylate free substrates, activation by the acyl-carrier protein is mandatory. Octanoyl-S-[BtrI acyl-carrier protein] is also accepted.