1.14.14.17: squalene monooxygenase

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For detailed information about squalene monooxygenase, go to the full flat file.

Word Map on EC 1.14.14.17

1.14.14.17

cholesterol

sterol

terbinafine

ergosterol

trichophyton

mevalonate

lanosterol

allylamine

2,3-oxidosqualene

hmg-coa

itraconazole

mentagrophytes

rubrum

oxidosqualene

terbinafine-resistant

tellurium

tinea

naftifine

interdigitale

antimycotic

bloch

griseofulvin

dammarenediol

dermatophytoses

cycloartenol

beta-amyrin

medicine

corporis

drug development

nutrition

biotechnology

pharmacology

cholesterogenic

synthesis

Reaction

Synonyms

CYP17, cytochrome P450 17alpha hydroxylase/17,20 lyase, EC 1.14.13.132, EC 1.14.99.7, Erg1, Erg1 protein, Erg1p, hydroxylase, squalene, oxygenase, squalene mono-, PgSQE1, PgSQE2, SE, SE1, SE3, SQE, SQE-I, SQE-II, sqe1, SQE3, SQLE, squalen expoxidase, squalene 2,3-epoxidase, squalene 2,3-oxidocyclase, squalene epoxidase, squalene epoxidase 1, squalene epoxidase 3, squalene hydroxylase, squalene mono-oxygenase, squalene oxydocyclase, squalene-2,3-epoxidase, squalene-2,3-epoxide cyclase, TkSQE1, TkSQE2, TkSQE3, TkSQE4

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

1.14.14.17 squalene monooxygenase

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Results	in table
15	Activating Compound
4611	AA Sequence
9	Application
1	CAS Registry Number
32	Cloned(Commentary)
41	Cofactor
2	Crystallization (Commentary)
167	Disease/ Diagnostics
14	Expression
22	General Information
2	General Stability
4	IC50 Value
154	Inhibitors
15	Ki Value [mM]
21	KM Value [mM]
27	Localization
1	Metals/Ions
16	Molecular Weight [Da]
28	Natural Substrates/ Products (Substrates)
154	Organism
7	Pathway
6	PDB ID
8	pH Optimum
7	pI Value
71	Protein Variants
15	Purification (Commentary)
5	Reaction
4	Reaction Type
81	Reference
2	Renatured (Commentary)
69	Source Tissue
8	Specific Activity [micromol/min/mg]
5	Storage Stability
71	Substrates and Products (Substrate)
18	Subunits
83	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
6	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 1.14.14.17 - squalene monooxygenase

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2-heptyl-4-hydroxyquinoline N-oxide

Candida albicans

0.1 mM, 236% stimulation

438203

2-hydroxyethyl jasmonate

Panax notoginseng

up-regulation of squalene expoxidase gene transcription

694930

Mega-9

Trichophyton rubrum

0.3%, 44% activation

438207

NADPH cytochrome c reductase

Rattus norvegicus

required for activity of N-terminal truncated recombinant enzyme in a concentration-dependent manner

438206

octyl beta-D-glucopyranoside

Trichophyton rubrum

0.3%, 42% activation

438207

Triton X-100

2 entries

additional information

8 entries