1.14.14.18: heme oxygenase (biliverdin-producing)
This is an abbreviated version!
For detailed information about heme oxygenase (biliverdin-producing), go to the full flat file.
Word Map on EC 1.14.14.18
-
1.14.14.18
-
monoxide
-
cytoprotective
-
endothelial
-
necrosis
-
dismutase
-
protoporphyrin
-
erythroid
-
2-related
-
tnf
-
bilirubin
-
artery
-
malondialdehyde
-
lipopolysaccharide
-
catalase
-
hemin
-
neuroprotective
-
ischemia
-
gsh
-
lps
-
sod
-
anti-oxidant
-
mapks
-
sirna
-
caspase-3
-
quinone
-
pulmonary
-
reperfusion
-
lps-induced
-
hypoxia
-
cyclooxygenase-2
-
cox-2
-
ferritin
-
erk
-
nf-e2-related
-
anti-apoptotic
-
cobalt
-
myeloperoxidase
-
ischemia-reperfusion
-
nrf2-mediated
-
pro-oxidant
-
kelch-like
-
nadph:quinone
-
factor-2
-
lps-stimulated
-
2-like
-
erythroid-derived
-
oxygenases
-
delta-aminolevulinic
-
sulforaphane
-
hyperbilirubinemia
-
medicine
-
drug development
-
analysis
- 1.14.14.18
- monoxide
-
cytoprotective
- endothelial
- necrosis
- dismutase
- protoporphyrin
-
erythroid
-
2-related
- tnf
- bilirubin
- artery
- malondialdehyde
- lipopolysaccharide
- catalase
- hemin
-
neuroprotective
- ischemia
- gsh
- lps
- sod
-
anti-oxidant
- mapks
- sirna
- caspase-3
- quinone
- pulmonary
-
reperfusion
-
lps-induced
- hypoxia
- cyclooxygenase-2
- cox-2
- ferritin
- erk
-
nf-e2-related
-
anti-apoptotic
- cobalt
- myeloperoxidase
-
ischemia-reperfusion
-
nrf2-mediated
-
pro-oxidant
-
kelch-like
-
nadph:quinone
-
factor-2
-
lps-stimulated
-
2-like
-
erythroid-derived
- oxygenases
-
delta-aminolevulinic
- sulforaphane
- hyperbilirubinemia
- medicine
- drug development
- analysis
Reaction
+ 3 [reduced NADPH-hemoprotein reductase] + 3 O2 = + + + 3 [oxidized NADPH-hemoprotein reductase] + 3 H2O
Synonyms
biliverdin-producing heme oxygenase, ChuS, ChuZ, EC 1.14.99.3, haem oxygenase, heme oxygenase, heme oxygenase 1, heme oxygenase 2, heme oxygenase-1, heme oxygenase-2, HemO, Hmox1, Hmox1a, Hmox1b, Hmox2, Hmox2a, Hmox2b, HmuO, Hmx1, HO, HO-1, HO-2, Ho1, Ho2, Ho3, HO4, HSP32, HugZ, HY1, inducible heme oxygenase-1, More, MsHO1, ORP33 proteins, oxygenase, heme (decyclizing), pbsA1, PigA, proteins, specific or class, ORP33 (oxygen-regulated protein 33,000-mol.-wt.), Syn HO-1, Syn HO-2
ECTree
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IC50 Value
IC50 Value on EC 1.14.14.18 - heme oxygenase (biliverdin-producing)
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0.00006
(+-)-1-(1H-imidazol-1-yl)-4-(4-iodophenyl)-2-butanol hydrochloride
Rattus norvegicus
-
IC50: 0.00006 mM
0.0062
(+-)-1-(1H-imidazol-1-yl)-4-phenyl-2-butanol hydrochloride
Rattus norvegicus
-
IC50: 0.0062 mM
0.00014
(+-)-4-(4-bromophenyl)-1-(1H-imidazol-1-yl)-2-butanol hydrochloride
Rattus norvegicus
-
IC50: 0.00014 mM
0.0005
(+-)-4-(4-chlorophenyl)-1-(1H-imidazol-1-yl)-2-butanol hydrochloride
Rattus norvegicus
-
IC50: 0.0005 mM
0.0014
(+-)-4-(4-fluorophenyl)-1-(1H-imidazol-1-yl)-2-butanol hydrochloride
Rattus norvegicus
-
IC50: 0.0014 mM
0.00173 - 0.0033
(2R,4R)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-(methoxymethyl)-1,3-dioxolane hydrochloride monohydrate
0.00059 - 0.0016
(2R,4R)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-(phenoxymethyl)-1,3-dioxolane hydrochloride
0.0008 - 0.0015
(2R,4R)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-methyl-1,3-dioxolane
0.01 - 0.026
(2R,4R)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane dihydrochloride dihydrate
0.009 - 0.015
(2R,4R)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-[(4-iodophenoxy)methyl]-1,3-dioxolane hydrochloride
0.00133 - 0.019
(2R,4R)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-[(4-methoxyphenoxy)methyl]-1,3-dioxolane hydrochloride
0.012 - 0.1
(2R,4R)-2-[2-(4-chlorophenyl)ethyl]-4-(hydroxymethyl)-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane hydrochloride
0.00067 - 0.0017
(2R,4R)-2-[2-(4-chlorophenyl)ethyl]-4-[(4-cyanophenoxy)methyl]-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane hydrochloride
0.00028 - 0.0005
(2R,4R)-2-[2-(4-chlorophenyl)ethyl]-4-[(4-fluorophenoxy)methyl]-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane hydrochloride
0.0018 - 0.0071
(2R,4R)-2-[2-(4-chlorophenyl)ethyl]-4-[(4-hydroxyphenoxy)methyl]-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane hydrochloride
0.0036 - 0.038
(2R,4R)-4-(azidomethyl)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane
0.1
(2R,4R)-4-[((4-adamantan-1-yl)phenoxy)methyl]-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane hydrochloride
0.0014 - 0.013
(2R,4R)-4-[(4-aminophenoxy)methyl]-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane dihydrochloride
0.0035 - 0.022
(2R,4R)-4-[(4-bromophenoxy)methyl]-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane hydrochloride
0.002 - 0.043
(2R,4R)-4-[(biphenyl-4-yloxy)methyl]-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane hydrochloride
0.0026
(2R,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)-methyl]-4-methyl-1,3-dioxolane
Rattus norvegicus
-
IC50: 0.0026 mM
0.0021 - 0.016
(2R,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-[((5-trifluoromethyl)pyridin-2-ylsulfanyl)methyl]-1,3-dioxolane hydrochloride
0.0021
(2R,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-[((5-trifluoromethylpyridin-2-yl)thio)methyl]-1,3-dioxolane
0.0007 - 0.0025
(2R,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-[(4-methoxyphenylsulfanyl)methyl]-1,3-dioxolane hydrochloride
0.006 - 0.019
(2R,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-[(4-nitrophenylsulfanyl)methyl]-1,3-dioxolane hydrochloride
0.009 - 0.019
(2R,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-[(methylthio)methyl]-1,3-dioxolane hydrochloride
0.0009 - 0.03
(2R,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-[(naphthalen-2-ylsulfanyl)methyl]-1,3-dioxolane hydrochloride
0.00103 - 0.034
(2R,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-[(phenylsulfanyl)methyl]-1,3-dioxolane hydrochloride
0.025 - 0.069
(2R,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-[(pyridin-4-ylsulfanyl)methyl]-1,3-dioxolane dihydrochloride
0.0012 - 0.0044
(2R,4S)-2-[2-(4-chlorophenyl)ethyl]-4-(fluoromethyl)-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane hydrochloride
0.0028 - 0.012
(2R,4S)-2-[2-(4-chlorophenyl)ethyl]-4-[(4-chlorophenylsulfanyl)methyl]-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane hydrochloride
0.0022 - 0.005
(2R,4S)-2-[2-(4-chlorophenyl)ethyl]-4-[(4-fluorophenylsulfanyl)methyl]-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane hydrochloride
0.0035 - 0.122
(2R,4S)-4-(chloromethyl)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane hydrochloride monohydrate
0.006 - 0.0123
(2R,4S)-4-[(2-bromophenylsulfanyl)methyl]-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane hydrochloride
0.005 - 0.022
(2R,4S)-4-[(3-bromophenylsulfanyl)methyl]-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane hydrochloride
0.0021 - 0.0024
(2R,4S)-4-[(4-bromophenylsulfanyl)methyl]-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane hydrochloride
0.02
(2S,4R)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)-methyl]-4-methyl-1,3-dioxolane
Rattus norvegicus
-
IC50: 0.02 mM
0.012
(2S,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-methyl-1,3-dioxolane
Rattus norvegicus
-
IC50: 0.012 mM
0.0019 - 100
1-((2-(2-(4-bromophenyl)ethyl)-1,3-dioxolan-2-yl)methyl)-1H-imidazole hydrochloride
0.0043 - 100
1-((2-(2-(4-chlorophenyl)ethyl)-1,3-dioxolan-2-yl)methyl)-1H-imidazole hydrochloride
0.0038 - 100
1-((2-(2-(4-fluorophenyl)ethyl)-1,3-dioxolan-2-yl)methyl)-1H-imidazole hydrochloride
0.0037 - 100
1-((2-(2-(4-iodophenyl)ethyl)-1,3-dioxolan-2-yl)methyl)-1H-imidazole hydrochloride
0.00027
1-(1H-imidazol-1-yl)-4,4-diphenyl-2-butanone
Homo sapiens
pH and temperature not specified in the publication
0.1
1-(4-bromophenyl)-2-[2-(1-methylethyl)-1H-imidazol-1-yl]ethanone
Rattus norvegicus
pH 7.4, 37°C
0.1
2-(norborn-2-yl)methyl-1H-benzimidazole
Rattus norvegicus
-
IC50 above 0.1 mM, isoform HO-1, at pH 7.4 and 37°C
0.00014
2-[2-(4-bromophenyl)ethyl]-2-[(1H-imidazol-1-yl) methyl]-1,3-dioxolane
Homo sapiens
pH and temperature not specified in the publication
0.0005
2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl) methyl]-1,3-dioxolane
Homo sapiens
pH and temperature not specified in the publication
0.004
2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane
Rattus norvegicus
-
IC50: 0.004 mM
0.0047
2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-1,3-dithiolane
Rattus norvegicus
-
IC50: 0.0047 mM
0.0014
2-[2-(4-fluorophenyl)ethyl]-2-[(1H-imidazol-1-yl) methyl]-1,3-dioxolane
Homo sapiens
pH and temperature not specified in the publication
0.0062
2-[2-phenylethyl]-2-[(1H-imidazol-1-yl) methyl]-1,3-dioxolane
Homo sapiens
pH and temperature not specified in the publication
0.00076
2-[2-phenylethyl]-2-[(1H-imidazol-1-yl)methyl]1,3-dioxolane
Homo sapiens
pH and temperature not specified in the publication
0.00406
4-phenyl-1-(1H-imidazol-1-yl)-2-butanone
Homo sapiens
pH and temperature not specified in the publication
0.06
Rattus norvegicus
-
pH 7.4, 37°C, spleen isozyme HO-1
1.8
(+/-)-1-(1H-imidazol-1-yl)-4-(4-iodophenyl)-2-butanol hydrochloride
Rattus norvegicus
-
pH 7.4, 37°C, brain isozyme HO-2
6.2
Rattus norvegicus
-
pH 7.4, 37°C, spleen isozyme HO-1
16
(+/-)-1-(1H-imidazol-1-yl)-4-phenyl-2-butanol hydrochloride
Rattus norvegicus
-
pH 7.4, 37°C, brain isozyme HO-2
0.14
Rattus norvegicus
-
pH 7.4, 37°C, spleen isozyme HO-1
2.6
(+/-)-4-(4-bromophenyl)-1-(1H-imidazol-1-yl)-2-butanol hydrochloride
Rattus norvegicus
-
pH 7.4, 37°C, brain isozyme HO-2
0.5
Rattus norvegicus
-
pH 7.4, 37°C, spleen isozyme HO-1
4
(+/-)-4-(4-chlorophenyl)-1-(1H-imidazol-1-yl)-2-butanol hydrochloride
Rattus norvegicus
-
pH 7.4, 37°C, brain isozyme HO-2
0.00006
Rattus norvegicus
substitution of the chlorophenyl group in the western region to a iodophenyl group
0.00014
(2-[2-(4-chlorophenyl)ethyl]-2-[1H-imidazol-1-yl)methyl]-1,3-dioxolane
Rattus norvegicus
substitution of the chlorophenyl group in the western region to a bromophenyl group
0.0014
(2-[2-(4-chlorophenyl)ethyl]-2-[1H-imidazol-1-yl)methyl]-1,3-dioxolane
Rattus norvegicus
substitution of the chlorophenyl group in the western region to a fluorophenyl group
0.004
(2-[2-(4-chlorophenyl)ethyl]-2-[1H-imidazol-1-yl)methyl]-1,3-dioxolane
Rattus norvegicus
-
0.0062
(2-[2-(4-chlorophenyl)ethyl]-2-[1H-imidazol-1-yl)methyl]-1,3-dioxolane
Rattus norvegicus
substitution of the chlorophenyl group in the western region to a phenyl group
0.00173
(2R,4R)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-(methoxymethyl)-1,3-dioxolane hydrochloride monohydrate
Rattus norvegicus
-
HO-1
0.0033
(2R,4R)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-(methoxymethyl)-1,3-dioxolane hydrochloride monohydrate
Rattus norvegicus
-
HO-2
0.00059
(2R,4R)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-(phenoxymethyl)-1,3-dioxolane hydrochloride
Rattus norvegicus
-
HO-1
0.0016
(2R,4R)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-(phenoxymethyl)-1,3-dioxolane hydrochloride
Rattus norvegicus
-
HO-2
0.0008
Rattus norvegicus
-
IC50: 0.0008 mM
0.0015
(2R,4R)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-methyl-1,3-dioxolane
Homo sapiens
-
IC50: 0.0015 mM
0.01
(2R,4R)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane dihydrochloride dihydrate
Rattus norvegicus
-
HO-1
0.026
(2R,4R)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane dihydrochloride dihydrate
Rattus norvegicus
-
HO-2
0.009
(2R,4R)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-[(4-iodophenoxy)methyl]-1,3-dioxolane hydrochloride
Rattus norvegicus
-
HO-1
0.015
(2R,4R)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-[(4-iodophenoxy)methyl]-1,3-dioxolane hydrochloride
Rattus norvegicus
-
HO-2
0.00133
(2R,4R)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-[(4-methoxyphenoxy)methyl]-1,3-dioxolane hydrochloride
Rattus norvegicus
-
HO-1
0.019
(2R,4R)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-[(4-methoxyphenoxy)methyl]-1,3-dioxolane hydrochloride
Rattus norvegicus
-
HO-2
0.012
(2R,4R)-2-[2-(4-chlorophenyl)ethyl]-4-(hydroxymethyl)-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane hydrochloride
Rattus norvegicus
-
HO-1
0.1
(2R,4R)-2-[2-(4-chlorophenyl)ethyl]-4-(hydroxymethyl)-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane hydrochloride
Rattus norvegicus
-
HO-2
0.00067
(2R,4R)-2-[2-(4-chlorophenyl)ethyl]-4-[(4-cyanophenoxy)methyl]-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane hydrochloride
Rattus norvegicus
-
HO-1
0.0017
(2R,4R)-2-[2-(4-chlorophenyl)ethyl]-4-[(4-cyanophenoxy)methyl]-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane hydrochloride
Rattus norvegicus
-
HO-2
0.00028
(2R,4R)-2-[2-(4-chlorophenyl)ethyl]-4-[(4-fluorophenoxy)methyl]-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane hydrochloride
Rattus norvegicus
-
HO-1
0.0005
(2R,4R)-2-[2-(4-chlorophenyl)ethyl]-4-[(4-fluorophenoxy)methyl]-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane hydrochloride
Rattus norvegicus
-
HO-2
0.0018
(2R,4R)-2-[2-(4-chlorophenyl)ethyl]-4-[(4-hydroxyphenoxy)methyl]-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane hydrochloride
Rattus norvegicus
-
HO-1
0.0071
(2R,4R)-2-[2-(4-chlorophenyl)ethyl]-4-[(4-hydroxyphenoxy)methyl]-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane hydrochloride
Rattus norvegicus
-
HO-2
0.0036
Rattus norvegicus
-
HO-1
0.038
(2R,4R)-4-(azidomethyl)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane
Rattus norvegicus
-
HO-2
0.1
(2R,4R)-4-[((4-adamantan-1-yl)phenoxy)methyl]-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane hydrochloride
Rattus norvegicus
-
HO-1
0.1
(2R,4R)-4-[((4-adamantan-1-yl)phenoxy)methyl]-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane hydrochloride
Rattus norvegicus
-
HO-2
0.0014
(2R,4R)-4-[(4-aminophenoxy)methyl]-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane dihydrochloride
Rattus norvegicus
-
HO-1
0.013
(2R,4R)-4-[(4-aminophenoxy)methyl]-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane dihydrochloride
Rattus norvegicus
-
HO-2
0.0035
(2R,4R)-4-[(4-bromophenoxy)methyl]-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane hydrochloride
Rattus norvegicus
-
HO-1
0.022
(2R,4R)-4-[(4-bromophenoxy)methyl]-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane hydrochloride
Rattus norvegicus
-
HO-2
0.002
(2R,4R)-4-[(biphenyl-4-yloxy)methyl]-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane hydrochloride
Rattus norvegicus
-
HO-1
0.043
(2R,4R)-4-[(biphenyl-4-yloxy)methyl]-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane hydrochloride
Rattus norvegicus
-
HO-2
0.0021
(2R,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-[((5-trifluoromethyl)pyridin-2-ylsulfanyl)methyl]-1,3-dioxolane hydrochloride
Rattus norvegicus
-
HO-1
0.016
(2R,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-[((5-trifluoromethyl)pyridin-2-ylsulfanyl)methyl]-1,3-dioxolane hydrochloride
Rattus norvegicus
-
HO-2
0.0021
(2R,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-[((5-trifluoromethylpyridin-2-yl)thio)methyl]-1,3-dioxolane
Homo sapiens
-
0.0021
(2R,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-[((5-trifluoromethylpyridin-2-yl)thio)methyl]-1,3-dioxolane
Homo sapiens
pH and temperature not specified in the publication
0.0007
(2R,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-[(4-methoxyphenylsulfanyl)methyl]-1,3-dioxolane hydrochloride
Rattus norvegicus
-
HO-1
0.0025
(2R,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-[(4-methoxyphenylsulfanyl)methyl]-1,3-dioxolane hydrochloride
Rattus norvegicus
-
HO-2
0.006
(2R,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-[(4-nitrophenylsulfanyl)methyl]-1,3-dioxolane hydrochloride
Rattus norvegicus
-
HO-1
0.019
(2R,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-[(4-nitrophenylsulfanyl)methyl]-1,3-dioxolane hydrochloride
Rattus norvegicus
-
HO-2
0.009
(2R,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-[(methylthio)methyl]-1,3-dioxolane hydrochloride
Rattus norvegicus
-
HO-1
0.019
(2R,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-[(methylthio)methyl]-1,3-dioxolane hydrochloride
Rattus norvegicus
-
HO-2
0.0009
(2R,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-[(naphthalen-2-ylsulfanyl)methyl]-1,3-dioxolane hydrochloride
Rattus norvegicus
-
HO-1
0.03
(2R,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-[(naphthalen-2-ylsulfanyl)methyl]-1,3-dioxolane hydrochloride
Rattus norvegicus
-
HO-2
0.00103
(2R,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-[(phenylsulfanyl)methyl]-1,3-dioxolane hydrochloride
Rattus norvegicus
-
HO-1
0.034
(2R,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-[(phenylsulfanyl)methyl]-1,3-dioxolane hydrochloride
Rattus norvegicus
-
HO-2
0.025
(2R,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-[(pyridin-4-ylsulfanyl)methyl]-1,3-dioxolane dihydrochloride
Rattus norvegicus
-
HO-1
0.069
(2R,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-[(pyridin-4-ylsulfanyl)methyl]-1,3-dioxolane dihydrochloride
Rattus norvegicus
-
HO-2
0.0012
(2R,4S)-2-[2-(4-chlorophenyl)ethyl]-4-(fluoromethyl)-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane hydrochloride
Rattus norvegicus
-
HO-1
0.0044
(2R,4S)-2-[2-(4-chlorophenyl)ethyl]-4-(fluoromethyl)-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane hydrochloride
Rattus norvegicus
-
HO-2
0.0028
(2R,4S)-2-[2-(4-chlorophenyl)ethyl]-4-[(4-chlorophenylsulfanyl)methyl]-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane hydrochloride
Rattus norvegicus
-
HO-1
0.012
(2R,4S)-2-[2-(4-chlorophenyl)ethyl]-4-[(4-chlorophenylsulfanyl)methyl]-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane hydrochloride
Rattus norvegicus
-
HO-2
0.0022
(2R,4S)-2-[2-(4-chlorophenyl)ethyl]-4-[(4-fluorophenylsulfanyl)methyl]-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane hydrochloride
Rattus norvegicus
-
HO-1
0.005
(2R,4S)-2-[2-(4-chlorophenyl)ethyl]-4-[(4-fluorophenylsulfanyl)methyl]-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane hydrochloride
Rattus norvegicus
-
HO-2
0.0035
(2R,4S)-4-(chloromethyl)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane hydrochloride monohydrate
Rattus norvegicus
-
HO-1
0.122
(2R,4S)-4-(chloromethyl)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane hydrochloride monohydrate
Rattus norvegicus
-
HO-2
0.006
(2R,4S)-4-[(2-bromophenylsulfanyl)methyl]-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane hydrochloride
Rattus norvegicus
-
HO-1
0.0123
(2R,4S)-4-[(2-bromophenylsulfanyl)methyl]-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane hydrochloride
Rattus norvegicus
-
HO-2
0.005
(2R,4S)-4-[(3-bromophenylsulfanyl)methyl]-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane hydrochloride
Rattus norvegicus
-
HO-1
0.022
(2R,4S)-4-[(3-bromophenylsulfanyl)methyl]-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane hydrochloride
Rattus norvegicus
-
HO-2
0.0021
(2R,4S)-4-[(4-bromophenylsulfanyl)methyl]-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane hydrochloride
Rattus norvegicus
-
HO-1
0.0024
(2R,4S)-4-[(4-bromophenylsulfanyl)methyl]-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane hydrochloride
Rattus norvegicus
-
HO-2
0.0019
Rattus norvegicus
-
IC50: 0.0019 mM
1.9
1-((2-(2-(4-bromophenyl)ethyl)-1,3-dioxolan-2-yl)methyl)-1H-imidazole hydrochloride
Rattus norvegicus
-
pH 7.4, 37°C, spleen isozyme HO-1
100
1-((2-(2-(4-bromophenyl)ethyl)-1,3-dioxolan-2-yl)methyl)-1H-imidazole hydrochloride
Rattus norvegicus
-
above, pH 7.4, 37°C, brain isozyme HO-2
0.0043
Rattus norvegicus
-
IC50: 0.0043 mM
1.4
1-((2-(2-(4-chlorophenyl)ethyl)-1,3-dioxolan-2-yl)methyl)-1H-imidazole hydrochloride
Rattus norvegicus
-
pH 7.4, 37°C, spleen isozyme HO-1
4.3
1-((2-(2-(4-chlorophenyl)ethyl)-1,3-dioxolan-2-yl)methyl)-1H-imidazole hydrochloride
Rattus norvegicus
-
pH 7.4, 37°C, spleen isozyme HO-1
17.9
1-((2-(2-(4-chlorophenyl)ethyl)-1,3-dioxolan-2-yl)methyl)-1H-imidazole hydrochloride
Rattus norvegicus
-
pH 7.4, 37°C, brain isozyme HO-2
100
1-((2-(2-(4-chlorophenyl)ethyl)-1,3-dioxolan-2-yl)methyl)-1H-imidazole hydrochloride
Rattus norvegicus
-
above, pH 7.4, 37°C, brain isozyme HO-2
0.0038
Rattus norvegicus
-
IC50: 0.0038 mM
3.8
1-((2-(2-(4-fluorophenyl)ethyl)-1,3-dioxolan-2-yl)methyl)-1H-imidazole hydrochloride
Rattus norvegicus
-
pH 7.4, 37°C, spleen isozyme HO-1
100
1-((2-(2-(4-fluorophenyl)ethyl)-1,3-dioxolan-2-yl)methyl)-1H-imidazole hydrochloride
Rattus norvegicus
-
above, pH 7.4, 37°C, brain isozyme HO-2
0.0037
Rattus norvegicus
-
IC50: 0.0037 mM
3.7
1-((2-(2-(4-iodophenyl)ethyl)-1,3-dioxolan-2-yl)methyl)-1H-imidazole hydrochloride
Rattus norvegicus
-
pH 7.4, 37°C, spleen isozyme HO-1
100
1-((2-(2-(4-iodophenyl)ethyl)-1,3-dioxolan-2-yl)methyl)-1H-imidazole hydrochloride
Rattus norvegicus
-
above, pH 7.4, 37°C, brain isozyme HO-2
0.0007
Rattus norvegicus
-
IC50: 0.0007 mM
0.7
1-((2-(2-phenylethyl)-1,3-dioxolan-2-yl)methyl)-1H-imidazole hydrochloride
Rattus norvegicus
-
pH 7.4, 37°C, spleen isozyme HO-1
100
1-((2-(2-phenylethyl)-1,3-dioxolan-2-yl)methyl)-1H-imidazole hydrochloride
Rattus norvegicus
-
above, pH 7.4, 37°C, brain isozyme HO-2
0.00011
Rattus norvegicus
-
IC50: 0.00011 mM
0.11
1-(1H-imidazol-1-yl)-4-(4-iodophenyl)-2-butanone hydrochloride
Rattus norvegicus
-
pH 7.4, 37°C, spleen isozyme HO-1
1.8
1-(1H-imidazol-1-yl)-4-(4-iodophenyl)-2-butanone hydrochloride
Rattus norvegicus
-
pH 7.4, 37°C, brain isozyme HO-2
0.004
Rattus norvegicus
-
IC50: 0.004 mM
4
1-(1H-imidazol-1-yl)-4-phenyl-2-butanone hydrochloride
Rattus norvegicus
-
pH 7.4, 37°C, spleen isozyme HO-1
11.3
1-(1H-imidazol-1-yl)-4-phenyl-2-butanone hydrochloride
Rattus norvegicus
-
pH 7.4, 37°C, brain isozyme HO-2
0.0027
Rattus norvegicus
-
isoform HO-1, at pH 7.4 and 37°C
0.0042
1-(4-bromobenzyl)-2-(1H-imidazol-1-yl)methyl-1H-benzimidazole
Rattus norvegicus
-
isoform HO-2, at pH 7.4 and 37°C
0.0301
Rattus norvegicus
-
isoform HO-2, at pH 7.4 and 37°C
0.1
1-(4-bromobenzyl)-2-(N-morpholinyl)methyl-1H-benzimidazole
Rattus norvegicus
-
IC50 above 0.1 mM, isoform HO-1, at pH 7.4 and 37°C
0.0051
Rattus norvegicus
-
isoform HO-2, at pH 7.4 and 37°C
0.1
1-(4-bromobenzyl)-2-(norborn-2-yl)methyl-1H-benzimidazole
Rattus norvegicus
-
IC50 above 0.1 mM, isoform HO-1, at pH 7.4 and 37°C
0.0084
Rattus norvegicus
-
isoform HO-2, at pH 7.4 and 37°C
0.0756
1-(4-bromobenzyl)-2-cyclopentylmethyl-1H-benzimidazole
Rattus norvegicus
-
isoform HO-1, at pH 7.4 and 37°C
0.0053
Rattus norvegicus
-
isoform HO-1, at pH 7.4 and 37°C
0.0085
1-(4-chlorobenzyl)-2-(1H-imidazol-1-yl)methyl-1H-benzimidazole
Rattus norvegicus
-
isoform HO-2, at pH 7.4 and 37°C
0.0043
Rattus norvegicus
-
isoform HO-2, at pH 7.4 and 37°C
0.1
1-(4-chlorobenzyl)-2-(2-norbornylmethyl)-1H-benzimidazole
Rattus norvegicus
-
IC50 above 0.1 mM, isoform HO-1, at pH 7.4 and 37°C
0.0319
Rattus norvegicus
-
isoform HO-2, at pH 7.4 and 37°C
0.1
1-(4-chlorobenzyl)-2-(N-morpholinyl)methyl-1H-benzimidazole
Rattus norvegicus
-
IC50 above 0.1 mM, isoform HO-1, at pH 7.4 and 37°C
0.0033
Rattus norvegicus
-
isoform HO-2, at pH 7.4 and 37°C
0.0324
1-(4-chlorobenzyl)-2-cyclopentylmethyl-1H-benzimidazole
Rattus norvegicus
-
isoform HO-1, at pH 7.4 and 37°C
0.1
Rattus norvegicus
-
IC50 above 0.1 mM, isoform HO-1, at pH 7.4 and 37°C
0.1
1-(4-methylbenzyl)-2-(N-morpholinyl)methyl-1H-benzimidazole
Rattus norvegicus
-
IC50 above 0.1 mM, isoform HO-2, at pH 7.4 and 37°C
0.0112
Rattus norvegicus
-
isoform HO-2, at pH 7.4 and 37°C
0.1
1-(4-methylbenzyl)-2-(norborn-2-yl)methyl-1H-benzimidazole
Rattus norvegicus
-
IC50 above 0.1 mM, isoform HO-1, at pH 7.4 and 37°C
0.0509
Rattus norvegicus
-
isoform HO-2, at pH 7.4 and 37°C
0.1
1-(n-heptyl)-2-(norborn-2-yl)methyl-1H-benzimidazole
Rattus norvegicus
-
IC50 above 0.1 mM, isoform HO-1, at pH 7.4 and 37°C
0.0173
Rattus norvegicus
-
isoform HO-2, at pH 7.4 and 37°C
0.1
1-(n-hexyl)-2-(norborn-2-yl)methyl-1H-benzimidazole
Rattus norvegicus
-
IC50 above 0.1 mM, isoform HO-1, at pH 7.4 and 37°C
0.0073
Rattus norvegicus
-
isoform HO-1, at pH 7.4 and 37°C
0.0499
1-benzyl-2-(1H-imidazol-1-yl)methyl-1H-benzimidazole
Rattus norvegicus
-
isoform HO-2, at pH 7.4 and 37°C
0.0643
Rattus norvegicus
-
isoform HO-2, at pH 7.4 and 37°C
0.1
1-benzyl-2-(N-morpholinyl)methyl-1H-benzimidazole
Rattus norvegicus
-
IC50 above 0.1 mM, isoform HO-1, at pH 7.4 and 37°C
0.0063
Rattus norvegicus
-
isoform HO-2, at pH 7.4 and 37°C
0.1
1-benzyl-2-(norborn-2-yl)methyl-1H-benzimidazole
Rattus norvegicus
-
IC50 above 0.1 mM, isoform HO-1, at pH 7.4 and 37°C
0.0103
Rattus norvegicus
-
isoform HO-2, at pH 7.4 and 37°C
0.1
1-benzyl-2-cyclohexylmethyl-1H-benzimidazole hydrochloride
Rattus norvegicus
-
IC50 above 0.1 mM, isoform HO-1, at pH 7.4 and 37°C
0.0054
Rattus norvegicus
-
isoform HO-2, at pH 7.4 and 37°C
0.1
1-bromobenzyl-2-cyclohexylmethyl-1H-benzimidazole
Rattus norvegicus
-
IC50 above 0.1 mM, isoform HO-1, at pH 7.4 and 37°C
0.0054
Rattus norvegicus
-
isoform HO-2, at pH 7.4 and 37°C
0.1
1-chlorobenzyl-2-cyclohexylmethyl-1H-benzimidazole
Rattus norvegicus
-
IC50 above 0.1 mM, isoform HO-1, at pH 7.4 and 37°C
0.1
Rattus norvegicus
-
IC50 above 0.1 mM, isoform HO-1, at pH 7.4 and 37°C
0.1
2-(1-cyclopentylmethyl)-1-(n-decyl)-1H-benzimidazole
Rattus norvegicus
-
IC50 above 0.1 mM, isoform HO-2, at pH 7.4 and 37°C
0.1
Rattus norvegicus
-
IC50 above 0.1 mM, isoform HO-1, at pH 7.4 and 37°C
0.1
2-(1-cyclopentylmethyl)-1-(n-heptyl)-1H-benzimidazole
Rattus norvegicus
-
IC50 above 0.1 mM, isoform HO-2, at pH 7.4 and 37°C
0.0363
Rattus norvegicus
-
isoform HO-2, at pH 7.4 and 37°C
0.1
2-(1-cyclopentylmethyl)-1-(n-hexyl)-1H-benzimidazole
Rattus norvegicus
-
IC50 above 0.1 mM, isoform HO-1, at pH 7.4 and 37°C
0.1
Rattus norvegicus
-
IC50 above 0.1 mM, isoform HO-1, at pH 7.4 and 37°C
0.1
2-(1-cyclopentylmethyl)-1-(n-octadecyl)-1H-benzimidazole
Rattus norvegicus
-
IC50 above 0.1 mM, isoform HO-2, at pH 7.4 and 37°C
0.0044
Rattus norvegicus
-
isoform HO-1, at pH 7.4 and 37°C
0.0079
2-(1H-imidazol-1-yl)methyl-1-(4-methylbenzyl)-1H-benzimidazole
Rattus norvegicus
-
isoform HO-2, at pH 7.4 and 37°C
0.0475
Rattus norvegicus
-
isoform HO-1, at pH 7.4 and 37°C
0.1
2-(1H-imidazol-1-yl)methyl-1H-benzimidazole
Rattus norvegicus
-
IC50 above 0.1 mM, isoform HO-2, at pH 7.4 and 37°C
0.1
Rattus norvegicus
-
IC50 above 0.1 mM, isoform HO-1, at pH 7.4 and 37°C
0.1
2-(N-morpholinyl)methyl-1H-benzimidazole
Rattus norvegicus
-
IC50 above 0.1 mM, isoform HO-2, at pH 7.4 and 37°C
0.0174
Rattus norvegicus
-
isoform HO-1, at pH 7.4 and 37°C
0.1
2-cyclohexylmethyl-1-(4-methylbenzyl)-1H-benzimidazole
Rattus norvegicus
-
IC50 above 0.1 mM, isoform HO-1, at pH 7.4 and 37°C
0.1
Rattus norvegicus
-
IC50 above 0.1 mM, isoform HO-1, at pH 7.4 and 37°C
0.1
2-cyclohexylmethyl-1-(n-decyl)-1H-benzimidazole
Rattus norvegicus
-
IC50 above 0.1 mM, isoform HO-2, at pH 7.4 and 37°C
0.0572
Rattus norvegicus
-
isoform HO-2, at pH 7.4 and 37°C
0.1
2-cyclohexylmethyl-1-(n-heptyl)-1H-benzimidazole
Rattus norvegicus
-
IC50 above 0.1 mM, isoform HO-1, at pH 7.4 and 37°C
0.0223
Rattus norvegicus
-
isoform HO-2, at pH 7.4 and 37°C
0.1
2-cyclohexylmethyl-1-(n-hexyl)-1H-benzimidazole
Rattus norvegicus
-
IC50 above 0.1 mM, isoform HO-1, at pH 7.4 and 37°C
0.1
Rattus norvegicus
-
IC50 above 0.1 mM, isoform HO-1, at pH 7.4 and 37°C
0.1
2-cyclohexylmethyl-1H-benzimidazole
Rattus norvegicus
-
IC50 above 0.1 mM, isoform HO-2, at pH 7.4 and 37°C
0.0086
Rattus norvegicus
-
isoform HO-2, at pH 7.4 and 37°C
0.0181
2-cyclopentylmethyl-1-(4-methylbenzyl)-1H-benzimidazole
Rattus norvegicus
-
isoform HO-1, at pH 7.4 and 37°C
0.1
Rattus norvegicus
-
IC50 above 0.1 mM, isoform HO-1, at pH 7.4 and 37°C
0.1
2-cyclopentylmethyl-1H-benzimidazole
Rattus norvegicus
-
IC50 above 0.1 mM, isoform HO-2, at pH 7.4 and 37°C
0.0017
Rattus norvegicus
-
IC50: 0.0017 mM
1.7
4-(4-bromophenyl)-1-(1H-imidazol-1-yl)-2-butanone hydrochloride
Rattus norvegicus
-
pH 7.4, 37°C, spleen isozyme HO-1
9.5
4-(4-bromophenyl)-1-(1H-imidazol-1-yl)-2-butanone hydrochloride
Rattus norvegicus
-
pH 7.4, 37°C, brain isozyme HO-2
0.0047
Rattus norvegicus
-
IC50: 0.0047 mM
4.7
4-(4-chlorophenyl)-1-(1H-imidazol-1-yl)-2-butanone hydrochloride
Rattus norvegicus
-
pH 7.4, 37°C, spleen isozyme HO-1
43.1
4-(4-chlorophenyl)-1-(1H-imidazol-1-yl)-2-butanone hydrochloride
Rattus norvegicus
-
pH 7.4, 37°C, brain isozyme HO-2
0.0027
Rattus norvegicus
-
IC50: 0.0027 mM
1.9
4-(4-fluorophenyl)-1-(1H-imidazol-1-yl)-2-butanone hydrochloride
Rattus norvegicus
-
pH 7.4, 37°C, brain isozyme HO-2
2.7
4-(4-fluorophenyl)-1-(1H-imidazol-1-yl)-2-butanone hydrochloride
Rattus norvegicus
-
pH 7.4, 37°C, spleen isozyme HO-1
0.0025
4-phenyl-1-(1,2,4-1H-triazol-1-yl)butan-2-one
Homo sapiens
pH and temperature not specified in the publication
0.089
4-phenyl-1-(1,2,4-1H-triazol-1-yl)butan-2-one
Homo sapiens
1,2,3-triazolyl variant
0.017
Homo sapiens
-
isozyme HO-1, pH not specified in the publication, temperature not specified in the publication
1.2
DTE
Homo sapiens
-
isozyme HO-2, pH not specified in the publication, temperature not specified in the publication